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• W2150571570 abstract "The mechanisms underlying induction and suppression of RNA silencing in the ongoing plant-virus arms race are poorly understood. We show here that virus-derived small RNAs produced by Arabidopsis Dicer-like 4 (DCL4) program an effector complex conferring antiviral immunity. Inhibition of DCL4 by a viral-encoded suppressor revealed the subordinate antiviral activity of DCL2. Accordingly, inactivating both DCL2 and DCL4 was necessary and sufficient to restore systemic infection of a suppressor-deficient virus. The effects of DCL2 were overcome by increasing viral dosage in inoculated leaves, but this could not surmount additional, non–cell autonomous effects of DCL4 specifically preventing viral unloading from the vasculature. These findings define a molecular framework for studying antiviral silencing and defense in plants." @default.
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• W2150571570 date "2006-07-07" @default.
• W2150571570 modified "2023-10-18" @default.
• W2150571570 title "Hierarchical Action and Inhibition of Plant Dicer-Like Proteins in Antiviral Defense" @default.
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• W2150571570 doi "https://doi.org/10.1126/science.1128214" @default.
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