FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150601565> ?p ?o ?g. }

• W2150601565 endingPage "433" @default.
• W2150601565 startingPage "427" @default.
• W2150601565 abstract "Endometrial breakthrough bleeding is characterized by an inflammatory reaction and increased production of proinflammatory mediators, one of which may be epithelial neutrophil-activating peptide-78 (ENA-78), a chemokine with neutrophil-activating properties.We therefore investigated the endometrial expression of ENA-78 in Norplant users as progestin-only contraceptive with various bleeding patterns (n=35) as compared with non-users with a normal menstrual cycle (n=55). The endometrial stromal cells (ESCs) were the major site of ENA-78 expression with the highest levels found during the secretory phase. The expression of ENA-78 was increased in Norplant users with irregular bleeding as compared with those with regular cycles and amenorrhoea. The levels of ENA-78 detected in uterine washes and sera after the use of Norplant for 3-6 months (n=25) increased compared with baseline (P < 0.05). These levels did not significantly change in Norplant users who received doxycycline (Dox) therapy (25 mg/twice daily for 6 months) when measured midway through or at the conclusion of study when compared with the baseline (n=25). Treatments with medroxyprogesterone acetate (MPA) and tumour necrosis factor-alpha (TNF-alpha) (25 ng/ml), but not 17beta-estradiol (E2) or E2 + MPA (10(-8) M), representing endometrium exposed to contraceptive and inflammatory conditions, respectively, increased the levels of ENA-78 production by ESCs, and this was reduced by co-treatments with Dox (25 microg/ml) (P < 0.05).The endometrial production of ENA-78 is altered in progestin-only contraceptive users experiencing breakthrough bleeding and is regulated by MPA and TNF-alpha in ESCs. Although Dox therapy did not alter uterine ENA-78 secretion, its suppression in ESCs suggests that Dox, acting site-specifically and through an anti-inflammatory mechanism, may influence the outcome of breakthrough bleeding in contraceptive users." @default.
• W2150601565 created "2016-06-24" @default.
• W2150601565 creator A5022485594 @default.
• W2150601565 creator A5024369252 @default.
• W2150601565 creator A5031138425 @default.
• W2150601565 creator A5049396596 @default.
• W2150601565 creator A5071868535 @default.
• W2150601565 date "2006-11-08" @default.
• W2150601565 modified "2023-09-24" @default.
• W2150601565 title "Endometrial expression of epithelial neutrophil-activating peptide-78 during the menstrual cycle or in progestin-only contraceptive users with breakthrough bleeding and the influence of doxycycline therapy" @default.
• W2150601565 cites W1497141930 @default.
• W2150601565 cites W1858898384 @default.
• W2150601565 cites W1976018801 @default.
• W2150601565 cites W1980620743 @default.
• W2150601565 cites W2005153538 @default.
• W2150601565 cites W2015652509 @default.
• W2150601565 cites W2016037432 @default.
• W2150601565 cites W2026781892 @default.
• W2150601565 cites W2028001014 @default.
• W2150601565 cites W2031468747 @default.
• W2150601565 cites W2035202357 @default.
• W2150601565 cites W2042617363 @default.
• W2150601565 cites W2051507168 @default.
• W2150601565 cites W2060797056 @default.
• W2150601565 cites W2068567241 @default.
• W2150601565 cites W2076036286 @default.
• W2150601565 cites W2082526193 @default.
• W2150601565 cites W2102404503 @default.
• W2150601565 cites W2109160378 @default.
• W2150601565 cites W2114428420 @default.
• W2150601565 cites W2115459118 @default.
• W2150601565 cites W2120914123 @default.
• W2150601565 cites W2127760302 @default.
• W2150601565 cites W2133184547 @default.
• W2150601565 cites W2140031202 @default.
• W2150601565 cites W2152239502 @default.
• W2150601565 cites W2157938668 @default.
• W2150601565 cites W323856910 @default.
• W2150601565 cites W4234772783 @default.
• W2150601565 doi "https://doi.org/10.1093/humrep/del398" @default.
• W2150601565 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17095519" @default.
• W2150601565 hasPublicationYear "2006" @default.
• W2150601565 type Work @default.
• W2150601565 sameAs 2150601565 @default.
• W2150601565 citedByCount "8" @default.
• W2150601565 countsByYear W21506015652013 @default.
• W2150601565 countsByYear W21506015652015 @default.
• W2150601565 countsByYear W21506015652016 @default.
• W2150601565 countsByYear W21506015652017 @default.
• W2150601565 crossrefType "journal-article" @default.
• W2150601565 hasAuthorship W2150601565A5022485594 @default.
• W2150601565 hasAuthorship W2150601565A5024369252 @default.
• W2150601565 hasAuthorship W2150601565A5031138425 @default.
• W2150601565 hasAuthorship W2150601565A5049396596 @default.
• W2150601565 hasAuthorship W2150601565A5071868535 @default.
• W2150601565 hasBestOaLocation W21506015651 @default.
• W2150601565 hasConcept C126322002 @default.
• W2150601565 hasConcept C134018914 @default.
• W2150601565 hasConcept C164027704 @default.
• W2150601565 hasConcept C2776306185 @default.
• W2150601565 hasConcept C2776607906 @default.
• W2150601565 hasConcept C2776914184 @default.
• W2150601565 hasConcept C2777164284 @default.
• W2150601565 hasConcept C2777687323 @default.
• W2150601565 hasConcept C2777702977 @default.
• W2150601565 hasConcept C2777902738 @default.
• W2150601565 hasConcept C2778690821 @default.
• W2150601565 hasConcept C2779058012 @default.
• W2150601565 hasConcept C2779076696 @default.
• W2150601565 hasConcept C2779742232 @default.
• W2150601565 hasConcept C2780186607 @default.
• W2150601565 hasConcept C2908647359 @default.
• W2150601565 hasConcept C29456083 @default.
• W2150601565 hasConcept C2986817661 @default.
• W2150601565 hasConcept C68324877 @default.
• W2150601565 hasConcept C71315377 @default.
• W2150601565 hasConcept C71924100 @default.
• W2150601565 hasConcept C99454951 @default.
• W2150601565 hasConceptScore W2150601565C126322002 @default.
• W2150601565 hasConceptScore W2150601565C134018914 @default.
• W2150601565 hasConceptScore W2150601565C164027704 @default.
• W2150601565 hasConceptScore W2150601565C2776306185 @default.
• W2150601565 hasConceptScore W2150601565C2776607906 @default.
• W2150601565 hasConceptScore W2150601565C2776914184 @default.
• W2150601565 hasConceptScore W2150601565C2777164284 @default.
• W2150601565 hasConceptScore W2150601565C2777687323 @default.
• W2150601565 hasConceptScore W2150601565C2777702977 @default.
• W2150601565 hasConceptScore W2150601565C2777902738 @default.
• W2150601565 hasConceptScore W2150601565C2778690821 @default.
• W2150601565 hasConceptScore W2150601565C2779058012 @default.
• W2150601565 hasConceptScore W2150601565C2779076696 @default.
• W2150601565 hasConceptScore W2150601565C2779742232 @default.
• W2150601565 hasConceptScore W2150601565C2780186607 @default.
• W2150601565 hasConceptScore W2150601565C2908647359 @default.
• W2150601565 hasConceptScore W2150601565C29456083 @default.
• W2150601565 hasConceptScore W2150601565C2986817661 @default.
• W2150601565 hasConceptScore W2150601565C68324877 @default.
• W2150601565 hasConceptScore W2150601565C71315377 @default.

• next