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• W2150611871 endingPage "2449" @default.
• W2150611871 startingPage "2441" @default.
• W2150611871 abstract "ABSTRACT Recent studies have suggested that phosphorylation of human p53 at Ser20 is important for stabilizing p53 in response to DNA damage through disruption of the interaction between MDM2 and p53. To examine the requirement for this DNA damage-induced phosphorylation event in a more physiological setting, we introduced a missense mutation into the endogenous p53 gene of mouse embryonic stem (ES) cells that changes serine 23 (S23), the murine equivalent of human serine 20, to alanine (A). Murine embryonic fibroblasts harboring the p53 S23A mutation accumulate p53 as well as p21 and Mdm2 proteins to normal levels after DNA damage. Furthermore, ES cells and thymocytes harboring the p53 S23A mutation also accumulate p53 protein to wild-type levels and undergo p53-dependent apoptosis similarly to wild-type cells after DNA damage. Therefore, phosphorylation of murine p53 at Ser23 is not required for p53 responses to DNA damage induced by UV and ionizing radiation treatment." @default.
• W2150611871 created "2016-06-24" @default.
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• W2150611871 date "2002-04-01" @default.
• W2150611871 modified "2023-09-27" @default.
• W2150611871 title "Mutation of Mouse p53 Ser23 and the Response to DNA Damage" @default.
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• W2150611871 doi "https://doi.org/10.1128/mcb.22.8.2441-2449.2002" @default.
• W2150611871 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/133708" @default.
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