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- W2150618302 endingPage "1160" @default.
- W2150618302 startingPage "1135" @default.
- W2150618302 abstract "ABSTRACT The major regulator controlling the physiological switch between aerobic and anaerobic growth conditions in Escherichia coli is the DNA binding protein FNR. To identify genes controlled by FNR, we used Affymetrix Antisense GeneChips to compare global gene expression profiles from isogenic MG1655 wild-type and Δ fnr strains grown in glucose minimal media under aerobic or anaerobic conditions. We found that 297 genes contained within 184 operons were regulated by FNR and/or by O 2 levels. The expression of many genes known to be involved in anaerobic respiration and fermentation was increased under anaerobic growth conditions, while that of genes involved in aerobic respiration and the tricarboxylic acid cycle were repressed as expected. The expression of nine operons associated with acid resistance was also increased under anaerobic growth conditions, which may reflect the production of acidic fermentation products. Ninety-one genes with no presently defined function were also altered in expression, including seven of the most highly anaerobically induced genes, six of which we found to be directly regulated by FNR. Classification of the 297 genes into eight groups by k -means clustering analysis indicated that genes with common gene expression patterns also had a strong functional relationship, providing clues for studying the function of unknown genes in each group. Six of the eight groups showed regulation by FNR; while some expression groups represent genes that are simply activated or repressed by FNR, others, such as those encoding functions for chemotaxis and motility, showed a more complex pattern of regulation. A computer search for FNR DNA binding sites within predicted promoter regions identified 63 new sites for 54 genes. We suggest that E. coli MG1655 has a larger metabolic potential under anaerobic conditions than has been previously recognized." @default.
- W2150618302 created "2016-06-24" @default.
- W2150618302 creator A5002142157 @default.
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- W2150618302 creator A5082740807 @default.
- W2150618302 creator A5085149040 @default.
- W2150618302 creator A5091424012 @default.
- W2150618302 date "2005-02-01" @default.
- W2150618302 modified "2023-09-29" @default.
- W2150618302 title "Genome-Wide Expression Analysis Indicates that FNR of <i>Escherichia coli</i> K-12 Regulates a Large Number of Genes of Unknown Function" @default.
- W2150618302 cites W1479977835 @default.
- W2150618302 cites W1480376833 @default.
- W2150618302 cites W1490790924 @default.
- W2150618302 cites W1493967421 @default.
- W2150618302 cites W1514995899 @default.
- W2150618302 cites W1552896036 @default.
- W2150618302 cites W1602686848 @default.
- W2150618302 cites W1606015018 @default.
- W2150618302 cites W1644047611 @default.
- W2150618302 cites W1646462907 @default.
- W2150618302 cites W1660421813 @default.
- W2150618302 cites W1757798472 @default.
- W2150618302 cites W1767772085 @default.
- W2150618302 cites W1862963917 @default.
- W2150618302 cites W1882966757 @default.
- W2150618302 cites W1885254586 @default.
- W2150618302 cites W1897335513 @default.
- W2150618302 cites W1926201851 @default.
- W2150618302 cites W1930985780 @default.
- W2150618302 cites W1964895626 @default.
- W2150618302 cites W1967605214 @default.
- W2150618302 cites W1973210959 @default.
- W2150618302 cites W1977671794 @default.
- W2150618302 cites W1980873743 @default.
- W2150618302 cites W1986876193 @default.
- W2150618302 cites W1987005877 @default.
- W2150618302 cites W1988859590 @default.
- W2150618302 cites W1990595232 @default.
- W2150618302 cites W1992825941 @default.
- W2150618302 cites W1993321575 @default.
- W2150618302 cites W1995796760 @default.
- W2150618302 cites W1997151746 @default.
- W2150618302 cites W1997955496 @default.
- W2150618302 cites W1999531408 @default.
- W2150618302 cites W1999758297 @default.
- W2150618302 cites W2000605827 @default.
- W2150618302 cites W2002872647 @default.
- W2150618302 cites W2018707809 @default.
- W2150618302 cites W2020163619 @default.
- W2150618302 cites W2022227481 @default.
- W2150618302 cites W2027425484 @default.
- W2150618302 cites W2035890664 @default.
- W2150618302 cites W2037957900 @default.
- W2150618302 cites W2040712576 @default.
- W2150618302 cites W2041254234 @default.
- W2150618302 cites W2041715942 @default.
- W2150618302 cites W2049257750 @default.
- W2150618302 cites W2051449352 @default.
- W2150618302 cites W2051829701 @default.
- W2150618302 cites W2054120201 @default.
- W2150618302 cites W2062175748 @default.
- W2150618302 cites W2062678518 @default.
- W2150618302 cites W2065824991 @default.
- W2150618302 cites W2066177000 @default.
- W2150618302 cites W2066363284 @default.
- W2150618302 cites W2080130499 @default.
- W2150618302 cites W2082000517 @default.
- W2150618302 cites W2084408406 @default.
- W2150618302 cites W2093318820 @default.
- W2150618302 cites W2094160282 @default.
- W2150618302 cites W2099738309 @default.
- W2150618302 cites W2106956389 @default.
- W2150618302 cites W2108377995 @default.
- W2150618302 cites W2116137883 @default.
- W2150618302 cites W2118225952 @default.
- W2150618302 cites W2127650182 @default.
- W2150618302 cites W2128095117 @default.
- W2150618302 cites W2129634655 @default.
- W2150618302 cites W2134153749 @default.
- W2150618302 cites W2134603596 @default.
- W2150618302 cites W2134934002 @default.
- W2150618302 cites W2137147102 @default.
- W2150618302 cites W2138457121 @default.
- W2150618302 cites W2140721971 @default.
- W2150618302 cites W2141650231 @default.
- W2150618302 cites W2143018675 @default.
- W2150618302 cites W2143273383 @default.
- W2150618302 cites W2146171755 @default.
- W2150618302 cites W2149141532 @default.
- W2150618302 cites W2150473143 @default.
- W2150618302 cites W2153228804 @default.
- W2150618302 cites W2155168552 @default.
- W2150618302 cites W2155297184 @default.
- W2150618302 cites W2157865313 @default.
- W2150618302 cites W2160902874 @default.
- W2150618302 cites W2162529910 @default.
- W2150618302 cites W2162568350 @default.
- W2150618302 cites W2168157737 @default.