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- W2150618589 abstract "To the Editor:We read with interest the recent article by Kooi et al,1 reporting their experience with ultrasmall superparamagnetic iron oxide (USPIO)–enhanced magnetic resonance (MR) imaging of carotid atheroma. This exploratory study holds promise for contrast-enhanced MR imaging of inflammatory lesions. We do express some reservations, however, regarding the authors’ methodology, conclusions, and the quality of the MR images on which they base their findings.It is unclear exactly how many of the patients given USPIO had a positive effect (ie, area of new/increased signal-intensity reduction) and in how many MR images this was evident. The authors, having made an effort to correlate USPIO accumulation with ruptured/rupture-prone histological sections, failed to say whether this translated to a signal loss on corresponding MR images, which is an important consideration before advocating the use of this methodology to identify inflamed carotid plaques. The authors suggested that in one patient, no USPIOs had accumulated because of a short …" @default.
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- W2150618589 date "2003-11-11" @default.
- W2150618589 modified "2023-10-11" @default.
- W2150618589 title "Accumulation of Ultrasmall Superparamagnetic Particles of Iron Oxide in Human Atherosclerotic Plaques" @default.
- W2150618589 cites W2129445703 @default.
- W2150618589 doi "https://doi.org/10.1161/01.cir.0000099904.42881.09" @default.
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