Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150620904> ?p ?o ?g. }
- W2150620904 endingPage "598" @default.
- W2150620904 startingPage "589" @default.
- W2150620904 abstract "Transplantation of hepatocytes is a promising therapy for end-stage liver disease, but the availability of functional cells currently precludes its clinical application. We now report a simple transient reprogramming approach to convert fibroblasts into hepatic-like cells. Human skin fibroblasts were treated with fish egg extracts to become the transiently remodeled cells (TRCs). After infected with retroviral EGFP, they were directly injected into the fetal monkey liver, where they underwent in situ differentiation in the hepatic niche. The hepatic-like cells were functional as shown by the synthesis of hepatic markers in vivo, including albumin, cytokeratin-18, and hepatic serum antigen. Similarly, when implanted in the mouse liver, the TRCs were differentiated into hepatic-like cells that synthesize albumin and CK18 and became completely integrated into the liver parenchyma. The potency of TRCs was mechanistically related to the activation of several signal pathways, which reactivate endogenous genes related to cell potency. This study demonstrates the feasibility of a simple and inexpensive epigenetic remodeling approach to convert human fibroblasts into therapeutic hepatic-like cells for the treatment of end-stage liver disease. J. Cell. Biochem. 117: 589–598, 2016. © 2015 Wiley Periodicals, Inc." @default.
- W2150620904 created "2016-06-24" @default.
- W2150620904 creator A5002768937 @default.
- W2150620904 creator A5008024833 @default.
- W2150620904 creator A5034918399 @default.
- W2150620904 creator A5036233749 @default.
- W2150620904 creator A5049936341 @default.
- W2150620904 creator A5059402098 @default.
- W2150620904 creator A5077198827 @default.
- W2150620904 creator A5084320016 @default.
- W2150620904 creator A5084985894 @default.
- W2150620904 date "2015-09-29" @default.
- W2150620904 modified "2023-10-16" @default.
- W2150620904 title "Converting Skin Fibroblasts into Hepatic-like Cells by Transient Programming" @default.
- W2150620904 cites W122029960 @default.
- W2150620904 cites W1608762409 @default.
- W2150620904 cites W1966016818 @default.
- W2150620904 cites W1966758700 @default.
- W2150620904 cites W1971804295 @default.
- W2150620904 cites W1981088384 @default.
- W2150620904 cites W1983653589 @default.
- W2150620904 cites W1989049899 @default.
- W2150620904 cites W1996005948 @default.
- W2150620904 cites W1999889167 @default.
- W2150620904 cites W2001284661 @default.
- W2150620904 cites W2002179012 @default.
- W2150620904 cites W2003214400 @default.
- W2150620904 cites W2004250167 @default.
- W2150620904 cites W2007394412 @default.
- W2150620904 cites W2008365696 @default.
- W2150620904 cites W2009359841 @default.
- W2150620904 cites W2018965952 @default.
- W2150620904 cites W2019229253 @default.
- W2150620904 cites W2020755558 @default.
- W2150620904 cites W2032534589 @default.
- W2150620904 cites W2034853493 @default.
- W2150620904 cites W2040572629 @default.
- W2150620904 cites W2040628909 @default.
- W2150620904 cites W2047951488 @default.
- W2150620904 cites W2049512082 @default.
- W2150620904 cites W2052002403 @default.
- W2150620904 cites W2053911973 @default.
- W2150620904 cites W2059378220 @default.
- W2150620904 cites W2061899690 @default.
- W2150620904 cites W2062758328 @default.
- W2150620904 cites W2069370163 @default.
- W2150620904 cites W2075104267 @default.
- W2150620904 cites W2075122609 @default.
- W2150620904 cites W2076486071 @default.
- W2150620904 cites W2083165947 @default.
- W2150620904 cites W2086663462 @default.
- W2150620904 cites W2095152292 @default.
- W2150620904 cites W2098273174 @default.
- W2150620904 cites W2102560467 @default.
- W2150620904 cites W2113844031 @default.
- W2150620904 cites W2125987139 @default.
- W2150620904 cites W2126580353 @default.
- W2150620904 cites W2126851387 @default.
- W2150620904 cites W2127905517 @default.
- W2150620904 cites W2128907902 @default.
- W2150620904 cites W2138977668 @default.
- W2150620904 cites W2145342569 @default.
- W2150620904 cites W2148346024 @default.
- W2150620904 cites W2161315819 @default.
- W2150620904 cites W2167006963 @default.
- W2150620904 cites W4212810156 @default.
- W2150620904 cites W4252890901 @default.
- W2150620904 cites W68928600 @default.
- W2150620904 doi "https://doi.org/10.1002/jcb.25355" @default.
- W2150620904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26312781" @default.
- W2150620904 hasPublicationYear "2015" @default.
- W2150620904 type Work @default.
- W2150620904 sameAs 2150620904 @default.
- W2150620904 citedByCount "5" @default.
- W2150620904 countsByYear W21506209042016 @default.
- W2150620904 countsByYear W21506209042017 @default.
- W2150620904 countsByYear W21506209042019 @default.
- W2150620904 countsByYear W21506209042022 @default.
- W2150620904 countsByYear W21506209042023 @default.
- W2150620904 crossrefType "journal-article" @default.
- W2150620904 hasAuthorship W2150620904A5002768937 @default.
- W2150620904 hasAuthorship W2150620904A5008024833 @default.
- W2150620904 hasAuthorship W2150620904A5034918399 @default.
- W2150620904 hasAuthorship W2150620904A5036233749 @default.
- W2150620904 hasAuthorship W2150620904A5049936341 @default.
- W2150620904 hasAuthorship W2150620904A5059402098 @default.
- W2150620904 hasAuthorship W2150620904A5077198827 @default.
- W2150620904 hasAuthorship W2150620904A5084320016 @default.
- W2150620904 hasAuthorship W2150620904A5084985894 @default.
- W2150620904 hasConcept C10882517 @default.
- W2150620904 hasConcept C126322002 @default.
- W2150620904 hasConcept C134018914 @default.
- W2150620904 hasConcept C142724271 @default.
- W2150620904 hasConcept C1491633281 @default.
- W2150620904 hasConcept C150903083 @default.
- W2150620904 hasConcept C176891718 @default.
- W2150620904 hasConcept C196822366 @default.
- W2150620904 hasConcept C203014093 @default.