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• W2150651871 endingPage "119" @default.
• W2150651871 startingPage "104" @default.
• W2150651871 abstract "Influenza A and B, and many unrelated viruses including rhinovirus, RSV, adenovirus, metapneumovirus and coronavirus share the same seasonality, since these viral acute respiratory tract infections (vARIs) are much more common in winter than summer. Unfortunately, early investigations that used recycled pedigree virus strains seem to have led microbiologists to dismiss the common folk belief that vARIs often follow chilling. Today, incontrovertible evidence shows that ambient temperature dips and host chilling increase the incidence and severity of vARIs. This review considers four possible mechanisms, M1 - 4, that can explain this link: (M1) increased crowding in winter may enhance viral transmission; (M2) lower temperatures may increase the stability of virions outside the body; (M3) chilling may increase host susceptibility; (M4) lower temperatures or host chilling may activate dormant virions. There is little evidence for M1 or M2, which are incompatible with tropical observations. Epidemiological anomalies such as the repeated simultaneous arrival of vARIs over wide geographical areas, the rapid cessation of influenza epidemics, and the low attack rate of influenza within families are compatible with M4, but not M3 (in its simple form). M4 seems to be the main driver of seasonality, but M3 may also play an important role." @default.
• W2150651871 created "2016-06-24" @default.
• W2150651871 creator A5068946627 @default.
• W2150651871 date "2016-01-01" @default.
• W2150651871 modified "2023-09-26" @default.
• W2150651871 title "Seasonality and selective trends in viral acute respiratory tract infections" @default.
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• W2150651871 doi "https://doi.org/10.1016/j.mehy.2015.11.005" @default.
• W2150651871 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7116927" @default.
• W2150651871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26608252" @default.
• W2150651871 hasPublicationYear "2016" @default.
• W2150651871 type Work @default.
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• W2150651871 citedByCount "44" @default.

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