FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150668114> ?p ?o ?g. }

• W2150668114 endingPage "62" @default.
• W2150668114 startingPage "56" @default.
• W2150668114 abstract "Background and Objectives Single‐donor or small‐pool cryoprecipitates are produced by blood establishments, mostly in developing countries, for substitute therapy in haemophilia A, von Willebrand disease and fibrinogen deficiency, as well as for the manufacture of fibrin sealant. As cryoprecipitate may be contaminated with pathogenic plasma‐borne viruses, there is an urgent need to develop a simple method for the viral inactivation of cryoprecipitate. Materials and Methods Cryoprecipitate was obtained according to standard procedures. Ten minipools of five or six donations of cryoprecipitate were prepared and subjected, in sterile closed bags, to a viral inactivation treatment using either 2% tri(n‐)butyl phosphate (TnBP) for 4 h at 37 °C or the combination of 1% TnBP and 1% Triton X‐45 for 4 h at 31 °C. The cryoprecipitates were subsequently extracted three times in their processing bags by mixing and decantation using 7·5% sterile ricinus oil. The TnBP‐treated cryoprecipitates were further subjected to a clarifying centrifugation step at 3800 g for 30 min. The final products were dispensed into individual bags and frozen at −30 °C or lower. Results The cryoprecipitates treated with either 2% TnBP or 1% TnBP + 1% Triton X‐45 showed excellent (> 93%) mean recovery of coagulant factor VIII (FVIII), ristocetin cofactor Von Willebrand factor (VWF:RCo), and clottable fibrinogen activity. Prothrombin time, international normalized ratio and activated partial thromboplastin time increased during solvent–detergent treatment but returned to initial values after oil extractions. The final content of TnBP and Triton X‐45 was < 10 and 50 ppm, indicating excellent removal by the oil‐extraction procedure. Conclusions Viral inactivation treatment by TnBP, with or without Triton X‐45, can be applied to minipools of cryoprecipitate, with good recovery of FVIII, VWF and fibrinogen. The viral inactivation and solvent–detergent removal process can be performed in a closed bag system and using simple blood establishment techniques and equipment. This technology could be considered for the improved viral safety of cryoprecipitate which is used to treat haemophilia A, von Willebrand disease or fibrinogen deficiency, or to prepare fibrin sealant." @default.
• W2150668114 created "2016-06-24" @default.
• W2150668114 creator A5006405586 @default.
• W2150668114 creator A5050137114 @default.
• W2150668114 creator A5073671726 @default.
• W2150668114 creator A5079679617 @default.
• W2150668114 creator A5083691166 @default.
• W2150668114 creator A5084510205 @default.
• W2150668114 date "2006-05-11" @default.
• W2150668114 modified "2023-10-10" @default.
• W2150668114 title "A minipool process for solvent-detergent treatment of cryoprecipitate at blood centres using a disposable bag system" @default.
• W2150668114 cites W1966616682 @default.
• W2150668114 cites W1970931331 @default.
• W2150668114 cites W1974793313 @default.
• W2150668114 cites W1978039741 @default.
• W2150668114 cites W1997291631 @default.
• W2150668114 cites W2007736523 @default.
• W2150668114 cites W2025853246 @default.
• W2150668114 cites W2028122839 @default.
• W2150668114 cites W2029496238 @default.
• W2150668114 cites W2030698519 @default.
• W2150668114 cites W2033247230 @default.
• W2150668114 cites W2038638906 @default.
• W2150668114 cites W2050281735 @default.
• W2150668114 cites W2053897717 @default.
• W2150668114 cites W2058135257 @default.
• W2150668114 cites W2068299747 @default.
• W2150668114 cites W2068533441 @default.
• W2150668114 cites W2068774909 @default.
• W2150668114 cites W2070871408 @default.
• W2150668114 cites W2070987839 @default.
• W2150668114 cites W2078445942 @default.
• W2150668114 cites W2082192168 @default.
• W2150668114 cites W2090831367 @default.
• W2150668114 cites W2092862135 @default.
• W2150668114 cites W2093493998 @default.
• W2150668114 cites W2101258310 @default.
• W2150668114 cites W2151794053 @default.
• W2150668114 cites W2155808129 @default.
• W2150668114 cites W2161453034 @default.
• W2150668114 cites W2166202528 @default.
• W2150668114 cites W2171117892 @default.
• W2150668114 cites W3155482280 @default.
• W2150668114 cites W39129397 @default.
• W2150668114 cites W4243059058 @default.
• W2150668114 cites W76194378 @default.
• W2150668114 doi "https://doi.org/10.1111/j.1423-0410.2006.00772.x" @default.
• W2150668114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16756602" @default.
• W2150668114 hasPublicationYear "2006" @default.
• W2150668114 type Work @default.
• W2150668114 sameAs 2150668114 @default.
• W2150668114 citedByCount "34" @default.
• W2150668114 countsByYear W21506681142012 @default.
• W2150668114 countsByYear W21506681142014 @default.
• W2150668114 countsByYear W21506681142015 @default.
• W2150668114 countsByYear W21506681142016 @default.
• W2150668114 countsByYear W21506681142017 @default.
• W2150668114 countsByYear W21506681142018 @default.
• W2150668114 countsByYear W21506681142019 @default.
• W2150668114 countsByYear W21506681142022 @default.
• W2150668114 crossrefType "journal-article" @default.
• W2150668114 hasAuthorship W2150668114A5006405586 @default.
• W2150668114 hasAuthorship W2150668114A5050137114 @default.
• W2150668114 hasAuthorship W2150668114A5073671726 @default.
• W2150668114 hasAuthorship W2150668114A5079679617 @default.
• W2150668114 hasAuthorship W2150668114A5083691166 @default.
• W2150668114 hasAuthorship W2150668114A5084510205 @default.
• W2150668114 hasConcept C126322002 @default.
• W2150668114 hasConcept C185592680 @default.
• W2150668114 hasConcept C203014093 @default.
• W2150668114 hasConcept C2778258694 @default.
• W2150668114 hasConcept C2778261982 @default.
• W2150668114 hasConcept C2778382381 @default.
• W2150668114 hasConcept C2779036427 @default.
• W2150668114 hasConcept C43617362 @default.
• W2150668114 hasConcept C54173615 @default.
• W2150668114 hasConcept C55493867 @default.
• W2150668114 hasConcept C71924100 @default.
• W2150668114 hasConcept C7623868 @default.
• W2150668114 hasConceptScore W2150668114C126322002 @default.
• W2150668114 hasConceptScore W2150668114C185592680 @default.
• W2150668114 hasConceptScore W2150668114C203014093 @default.
• W2150668114 hasConceptScore W2150668114C2778258694 @default.
• W2150668114 hasConceptScore W2150668114C2778261982 @default.
• W2150668114 hasConceptScore W2150668114C2778382381 @default.
• W2150668114 hasConceptScore W2150668114C2779036427 @default.
• W2150668114 hasConceptScore W2150668114C43617362 @default.
• W2150668114 hasConceptScore W2150668114C54173615 @default.
• W2150668114 hasConceptScore W2150668114C55493867 @default.
• W2150668114 hasConceptScore W2150668114C71924100 @default.
• W2150668114 hasConceptScore W2150668114C7623868 @default.
• W2150668114 hasIssue "1" @default.
• W2150668114 hasLocation W21506681141 @default.
• W2150668114 hasLocation W21506681142 @default.
• W2150668114 hasOpenAccess W2150668114 @default.
• W2150668114 hasPrimaryLocation W21506681141 @default.
• W2150668114 hasRelatedWork W1972585653 @default.
• W2150668114 hasRelatedWork W1985030818 @default.

• next