Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150671248> ?p ?o ?g. }
- W2150671248 endingPage "85" @default.
- W2150671248 startingPage "77" @default.
- W2150671248 abstract "Although recurrent epithelial ovarian cancer initially responds well to current first-line adjuvant therapy, eventually the disease becomes resistant to chemotherapy. Novel strategies are needed to reverse chemoresistance in order to treat relapsed ovarian cancer effectively. One strategy is to target aberrant expression activation of Aurora kinases that are essential for the regulation of chromosome segregation and cytokinesis during mitosis and which play a role in tumourigenesis and progression in a wide range of human tumours, including ovarian cancer. The purpose of this article is to review Aurora kinases and their inhibitors in human epithelial ovarian cancer as an impetus to the development of effective and less toxic regimens for ovarian cancer. In addition, this review tries to define the differences between cytotoxic chemotherapeutic agents and molecular therapeutic agents: both groups of agents have either a single specific target or multiple specific targets, while their differences lie in their toxicity profiles and the way to determine their dosages for further studies. The authors propose that Aurora kinase inhibitors be developed as molecular therapeutic agents in order to minimise their toxicities and maximise their antitumour activities for ovarian cancer treatment." @default.
- W2150671248 created "2016-06-24" @default.
- W2150671248 creator A5009043320 @default.
- W2150671248 creator A5031553531 @default.
- W2150671248 creator A5078453039 @default.
- W2150671248 creator A5080242644 @default.
- W2150671248 date "2006-01-27" @default.
- W2150671248 modified "2023-09-23" @default.
- W2150671248 title "Targeting Aurora kinases in ovarian cancer" @default.
- W2150671248 cites W1506072215 @default.
- W2150671248 cites W1556655356 @default.
- W2150671248 cites W1568426705 @default.
- W2150671248 cites W1966951204 @default.
- W2150671248 cites W1969063265 @default.
- W2150671248 cites W1980577287 @default.
- W2150671248 cites W1990317973 @default.
- W2150671248 cites W1990428670 @default.
- W2150671248 cites W1998258610 @default.
- W2150671248 cites W2007105351 @default.
- W2150671248 cites W2010397777 @default.
- W2150671248 cites W2027516869 @default.
- W2150671248 cites W2033923680 @default.
- W2150671248 cites W2035179505 @default.
- W2150671248 cites W2041179357 @default.
- W2150671248 cites W2046553897 @default.
- W2150671248 cites W2050537958 @default.
- W2150671248 cites W2051717153 @default.
- W2150671248 cites W2060921605 @default.
- W2150671248 cites W2069910776 @default.
- W2150671248 cites W2071156666 @default.
- W2150671248 cites W2081731778 @default.
- W2150671248 cites W2088309079 @default.
- W2150671248 cites W2089596886 @default.
- W2150671248 cites W2089806746 @default.
- W2150671248 cites W2090131485 @default.
- W2150671248 cites W2093549611 @default.
- W2150671248 cites W2102380728 @default.
- W2150671248 cites W2106942695 @default.
- W2150671248 cites W2110944043 @default.
- W2150671248 cites W2113462447 @default.
- W2150671248 cites W2114220172 @default.
- W2150671248 cites W2114833193 @default.
- W2150671248 cites W2124919005 @default.
- W2150671248 cites W2128553601 @default.
- W2150671248 cites W2134064448 @default.
- W2150671248 cites W2134931983 @default.
- W2150671248 cites W2137429755 @default.
- W2150671248 cites W2140572549 @default.
- W2150671248 cites W2148649353 @default.
- W2150671248 cites W2151779190 @default.
- W2150671248 cites W2155225188 @default.
- W2150671248 cites W2155660862 @default.
- W2150671248 cites W2157153074 @default.
- W2150671248 cites W2158160769 @default.
- W2150671248 cites W2234399790 @default.
- W2150671248 cites W2279017153 @default.
- W2150671248 cites W2419653285 @default.
- W2150671248 cites W4252646692 @default.
- W2150671248 doi "https://doi.org/10.1517/14728222.10.1.77" @default.
- W2150671248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16441230" @default.
- W2150671248 hasPublicationYear "2006" @default.
- W2150671248 type Work @default.
- W2150671248 sameAs 2150671248 @default.
- W2150671248 citedByCount "20" @default.
- W2150671248 countsByYear W21506712482012 @default.
- W2150671248 countsByYear W21506712482013 @default.
- W2150671248 countsByYear W21506712482016 @default.
- W2150671248 countsByYear W21506712482017 @default.
- W2150671248 countsByYear W21506712482020 @default.
- W2150671248 crossrefType "journal-article" @default.
- W2150671248 hasAuthorship W2150671248A5009043320 @default.
- W2150671248 hasAuthorship W2150671248A5031553531 @default.
- W2150671248 hasAuthorship W2150671248A5078453039 @default.
- W2150671248 hasAuthorship W2150671248A5080242644 @default.
- W2150671248 hasConcept C121608353 @default.
- W2150671248 hasConcept C126322002 @default.
- W2150671248 hasConcept C184235292 @default.
- W2150671248 hasConcept C20552341 @default.
- W2150671248 hasConcept C2779425043 @default.
- W2150671248 hasConcept C2780427987 @default.
- W2150671248 hasConcept C2780808130 @default.
- W2150671248 hasConcept C29537977 @default.
- W2150671248 hasConcept C502942594 @default.
- W2150671248 hasConcept C54355233 @default.
- W2150671248 hasConcept C60644358 @default.
- W2150671248 hasConcept C71924100 @default.
- W2150671248 hasConcept C86803240 @default.
- W2150671248 hasConceptScore W2150671248C121608353 @default.
- W2150671248 hasConceptScore W2150671248C126322002 @default.
- W2150671248 hasConceptScore W2150671248C184235292 @default.
- W2150671248 hasConceptScore W2150671248C20552341 @default.
- W2150671248 hasConceptScore W2150671248C2779425043 @default.
- W2150671248 hasConceptScore W2150671248C2780427987 @default.
- W2150671248 hasConceptScore W2150671248C2780808130 @default.
- W2150671248 hasConceptScore W2150671248C29537977 @default.
- W2150671248 hasConceptScore W2150671248C502942594 @default.
- W2150671248 hasConceptScore W2150671248C54355233 @default.
- W2150671248 hasConceptScore W2150671248C60644358 @default.