Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150675420> ?p ?o ?g. }
- W2150675420 endingPage "1954" @default.
- W2150675420 startingPage "1943" @default.
- W2150675420 abstract "The metastasis suppressor, N-myc downstream regulated gene 1 (NDRG1), is negatively correlated with tumor progression in multiple neoplasms, being a promising new target for cancer treatment. However, the precise molecular effects of NDRG1 remain unclear. Herein, we summarize recent advances in understanding the impact of NDRG1 on cancer metastasis with emphasis on its interactions with the key oncogenic nuclear factor-kappaB, phosphatidylinositol-3 kinase/phosphorylated AKT/mammalian target of rapamycin and Ras/Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling pathways. Recent studies demonstrating the inhibitory effects of NDRG1 on the epithelial-mesenchymal transition, a key initial step in metastasis, TGF-β pathway and the Wnt/β-catenin pathway are also described. Furthermore, NDRG1 was also demonstrated to regulate molecular motors in cancer cells, leading to inhibition of F-actin polymerization, stress fiber formation and subsequent reduction of cancer cell migration. Collectively, this review summarizes the underlying molecular mechanisms of the antimetastatic effects of NDRG1 in cancer cells." @default.
- W2150675420 created "2016-06-24" @default.
- W2150675420 creator A5000546435 @default.
- W2150675420 creator A5008234461 @default.
- W2150675420 creator A5010643006 @default.
- W2150675420 creator A5015216800 @default.
- W2150675420 creator A5025789604 @default.
- W2150675420 creator A5058673686 @default.
- W2150675420 creator A5061763563 @default.
- W2150675420 creator A5069039520 @default.
- W2150675420 creator A5075875051 @default.
- W2150675420 creator A5085240549 @default.
- W2150675420 creator A5089319540 @default.
- W2150675420 date "2013-05-13" @default.
- W2150675420 modified "2023-10-14" @default.
- W2150675420 title "Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors" @default.
- W2150675420 cites W1517206505 @default.
- W2150675420 cites W1545275730 @default.
- W2150675420 cites W155026867 @default.
- W2150675420 cites W1571406711 @default.
- W2150675420 cites W1596038553 @default.
- W2150675420 cites W173128540 @default.
- W2150675420 cites W1760215417 @default.
- W2150675420 cites W1857706205 @default.
- W2150675420 cites W1893667581 @default.
- W2150675420 cites W1966201817 @default.
- W2150675420 cites W1967650077 @default.
- W2150675420 cites W1969365651 @default.
- W2150675420 cites W1970028262 @default.
- W2150675420 cites W1971272503 @default.
- W2150675420 cites W1976382352 @default.
- W2150675420 cites W1977267072 @default.
- W2150675420 cites W1977450402 @default.
- W2150675420 cites W1978470337 @default.
- W2150675420 cites W1978567238 @default.
- W2150675420 cites W1980354178 @default.
- W2150675420 cites W1981125188 @default.
- W2150675420 cites W1981356016 @default.
- W2150675420 cites W1983074899 @default.
- W2150675420 cites W1983411366 @default.
- W2150675420 cites W1984174151 @default.
- W2150675420 cites W1984582082 @default.
- W2150675420 cites W1985516721 @default.
- W2150675420 cites W1987585487 @default.
- W2150675420 cites W1987815966 @default.
- W2150675420 cites W198944900 @default.
- W2150675420 cites W1989606460 @default.
- W2150675420 cites W1991183176 @default.
- W2150675420 cites W1991678197 @default.
- W2150675420 cites W1993186949 @default.
- W2150675420 cites W1997087774 @default.
- W2150675420 cites W1998203489 @default.
- W2150675420 cites W1999576743 @default.
- W2150675420 cites W1999916995 @default.
- W2150675420 cites W2000405060 @default.
- W2150675420 cites W2006419043 @default.
- W2150675420 cites W2007452431 @default.
- W2150675420 cites W2008037148 @default.
- W2150675420 cites W2011763778 @default.
- W2150675420 cites W2013193930 @default.
- W2150675420 cites W2013511472 @default.
- W2150675420 cites W2018893673 @default.
- W2150675420 cites W2019058511 @default.
- W2150675420 cites W2020603912 @default.
- W2150675420 cites W2022906514 @default.
- W2150675420 cites W2027241628 @default.
- W2150675420 cites W2027600681 @default.
- W2150675420 cites W2029022457 @default.
- W2150675420 cites W2029548767 @default.
- W2150675420 cites W2033047883 @default.
- W2150675420 cites W2035115690 @default.
- W2150675420 cites W2048047549 @default.
- W2150675420 cites W2051174029 @default.
- W2150675420 cites W2051481113 @default.
- W2150675420 cites W2057737594 @default.
- W2150675420 cites W2059158933 @default.
- W2150675420 cites W2061809197 @default.
- W2150675420 cites W2066419333 @default.
- W2150675420 cites W2066728549 @default.
- W2150675420 cites W2069618090 @default.
- W2150675420 cites W2070033435 @default.
- W2150675420 cites W2070732456 @default.
- W2150675420 cites W2071497196 @default.
- W2150675420 cites W2072401753 @default.
- W2150675420 cites W2073222527 @default.
- W2150675420 cites W2075169994 @default.
- W2150675420 cites W2077102469 @default.
- W2150675420 cites W2077778039 @default.
- W2150675420 cites W2079330086 @default.
- W2150675420 cites W2080692619 @default.
- W2150675420 cites W2085736792 @default.
- W2150675420 cites W2086605620 @default.
- W2150675420 cites W2087422732 @default.
- W2150675420 cites W2090463559 @default.
- W2150675420 cites W2091849811 @default.
- W2150675420 cites W2093646219 @default.
- W2150675420 cites W2096892716 @default.
- W2150675420 cites W2097478087 @default.