FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150698686> ?p ?o ?g. }

• W2150698686 endingPage "1935" @default.
• W2150698686 startingPage "1929" @default.
• W2150698686 abstract "The effects of inhibitors of arachidonic acid metabolism and antioxidants on the rat liver tumor promotion activity of phenobarbital (PB) were assessed using the enzyme-altered focus as the end-point lesion. Fischer 344 male rats were initiated with N-nitrosodiethylamine (200 mg/kg) and then divided into five groups placed on basal diet, diet containing 0.05% PB, diet containing 0.05% PB plus 0.75%, 1% or 1.5% levels of various inhibitors of arachidonic acid metabolism or antioxidants, or diet containing 1% or 1.5% inhibitors or antioxidants alone for 10 weeks, and then killed. ρ-Bromo phenacyl bromide, an inhibitor of phospholipase A2 signifi cantly inhibited the promotion activity of PB at dose levels of 0.75% and 1.5%, reaching plateau at 0.75%. Both quercetin, an inhibitor of lipoxygenase, and morin, a dual inhibitor of lipoxygenase-cyclooxygenase, significantly reduced the promotion activity of PB at the 1.5% but not 0.75% dose levels. Moreover, acetylsalicylic acid, an inhibitor of cyclooxygenase dose-dependently inhibited the promotion activity of PB. Among the antioxidants investigated, vitamin E did not affect, but n-propyl gallate and ethoxyquin exerted a dose-dependent inhibition of PB promotion. These results are strongly suggestive of an involvement of phospholipase A2 lipoxygenase and cyclooxygenase arachidonic acid metabolic pathways in the mechanisms underlying PB enhancement of hepatocarcinogenesis." @default.
• W2150698686 created "2016-06-24" @default.
• W2150698686 creator A5003762166 @default.
• W2150698686 creator A5004506343 @default.
• W2150698686 creator A5034471747 @default.
• W2150698686 creator A5045869785 @default.
• W2150698686 creator A5050016133 @default.
• W2150698686 creator A5058895525 @default.
• W2150698686 creator A5072873559 @default.
• W2150698686 creator A5086799435 @default.
• W2150698686 creator A5088612923 @default.
• W2150698686 date "1989-01-01" @default.
• W2150698686 modified "2023-10-14" @default.
• W2150698686 title "Possible involvement of arachidonic acid metabolism in phenobarbital promotion of hepatocarcinogenesis" @default.
• W2150698686 cites W138546028 @default.
• W2150698686 cites W142482983 @default.
• W2150698686 cites W1546910140 @default.
• W2150698686 cites W1595520662 @default.
• W2150698686 cites W1971988464 @default.
• W2150698686 cites W1973220852 @default.
• W2150698686 cites W1983759759 @default.
• W2150698686 cites W1986735216 @default.
• W2150698686 cites W1998167871 @default.
• W2150698686 cites W2005381573 @default.
• W2150698686 cites W2013581100 @default.
• W2150698686 cites W2021085921 @default.
• W2150698686 cites W2021494550 @default.
• W2150698686 cites W2032799751 @default.
• W2150698686 cites W2039956459 @default.
• W2150698686 cites W2057815378 @default.
• W2150698686 cites W2060880435 @default.
• W2150698686 cites W2063198055 @default.
• W2150698686 cites W2065395270 @default.
• W2150698686 cites W2076199194 @default.
• W2150698686 cites W2083163456 @default.
• W2150698686 cites W2086790670 @default.
• W2150698686 cites W2129733379 @default.
• W2150698686 cites W2151979934 @default.
• W2150698686 cites W222863809 @default.
• W2150698686 cites W2406991164 @default.
• W2150698686 cites W2504297605 @default.
• W2150698686 doi "https://doi.org/10.1093/carcin/10.10.1929" @default.
• W2150698686 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2571427" @default.
• W2150698686 hasPublicationYear "1989" @default.
• W2150698686 type Work @default.
• W2150698686 sameAs 2150698686 @default.
• W2150698686 citedByCount "46" @default.
• W2150698686 countsByYear W21506986862014 @default.
• W2150698686 countsByYear W21506986862015 @default.
• W2150698686 crossrefType "journal-article" @default.
• W2150698686 hasAuthorship W2150698686A5003762166 @default.
• W2150698686 hasAuthorship W2150698686A5004506343 @default.
• W2150698686 hasAuthorship W2150698686A5034471747 @default.
• W2150698686 hasAuthorship W2150698686A5045869785 @default.
• W2150698686 hasAuthorship W2150698686A5050016133 @default.
• W2150698686 hasAuthorship W2150698686A5058895525 @default.
• W2150698686 hasAuthorship W2150698686A5072873559 @default.
• W2150698686 hasAuthorship W2150698686A5086799435 @default.
• W2150698686 hasAuthorship W2150698686A5088612923 @default.
• W2150698686 hasConcept C104317684 @default.
• W2150698686 hasConcept C134018914 @default.
• W2150698686 hasConcept C181199279 @default.
• W2150698686 hasConcept C185592680 @default.
• W2150698686 hasConcept C2776551241 @default.
• W2150698686 hasConcept C2776889390 @default.
• W2150698686 hasConcept C2777376040 @default.
• W2150698686 hasConcept C2778004101 @default.
• W2150698686 hasConcept C2778078955 @default.
• W2150698686 hasConcept C2778793413 @default.
• W2150698686 hasConcept C2779689624 @default.
• W2150698686 hasConcept C2780122803 @default.
• W2150698686 hasConcept C2781263971 @default.
• W2150698686 hasConcept C55493867 @default.
• W2150698686 hasConcept C555283112 @default.
• W2150698686 hasConcept C86803240 @default.
• W2150698686 hasConcept C98274493 @default.
• W2150698686 hasConceptScore W2150698686C104317684 @default.
• W2150698686 hasConceptScore W2150698686C134018914 @default.
• W2150698686 hasConceptScore W2150698686C181199279 @default.
• W2150698686 hasConceptScore W2150698686C185592680 @default.
• W2150698686 hasConceptScore W2150698686C2776551241 @default.
• W2150698686 hasConceptScore W2150698686C2776889390 @default.
• W2150698686 hasConceptScore W2150698686C2777376040 @default.
• W2150698686 hasConceptScore W2150698686C2778004101 @default.
• W2150698686 hasConceptScore W2150698686C2778078955 @default.
• W2150698686 hasConceptScore W2150698686C2778793413 @default.
• W2150698686 hasConceptScore W2150698686C2779689624 @default.
• W2150698686 hasConceptScore W2150698686C2780122803 @default.
• W2150698686 hasConceptScore W2150698686C2781263971 @default.
• W2150698686 hasConceptScore W2150698686C55493867 @default.
• W2150698686 hasConceptScore W2150698686C555283112 @default.
• W2150698686 hasConceptScore W2150698686C86803240 @default.
• W2150698686 hasConceptScore W2150698686C98274493 @default.
• W2150698686 hasIssue "10" @default.
• W2150698686 hasLocation W21506986861 @default.
• W2150698686 hasLocation W21506986862 @default.
• W2150698686 hasOpenAccess W2150698686 @default.
• W2150698686 hasPrimaryLocation W21506986861 @default.

• next