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• W2150716512 abstract "Based on the examination of the X-ray crystallographic structures of the LBD of TRα and TRβ in complex with KB-141 (2), a number of novel 4′-hydroxy bioisosteric thyromimetics were prepared. Optimal affinity and β-selectivity (33 times), was found with a medium-sized alkyl-substituted amido group; iso-butyl (12c). It can be concluded that bioisosteric replacements of the 4′-hydroxy position represent a new promising class of TRβ-selective synthetic thyromimetics." @default.
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• W2150716512 date "2006-02-01" @default.
• W2150716512 modified "2023-10-03" @default.
• W2150716512 title "Thyroid receptor ligands. Part 4: 4′-amido bioisosteric ligands selective for the thyroid hormone receptor beta" @default.
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• W2150716512 doi "https://doi.org/10.1016/j.bmcl.2005.11.002" @default.
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