FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150740586> ?p ?o ?g. }

• W2150740586 endingPage "14686" @default.
• W2150740586 startingPage "14681" @default.
• W2150740586 abstract "Follicular dendritic cells (FDC) provide a reservoir for HIV type 1 (HIV-1) that may reignite infection if highly active antiretroviral therapy (HAART) is withdrawn before virus on FDC is cleared. To estimate the treatment time required to eliminate HIV-1 on FDC, we develop deterministic and stochastic models for the reversible binding of HIV-1 to FDC via ligand-receptor interactions and examine the consequences of reducing the virus available for binding to FDC. Analysis of these models shows that the rate at which HIV-1 dissociates from FDC during HAART is biphasic, with an initial period of rapid decay followed by a period of slower exponential decay. The speed of the slower second stage of dissociation and the treatment time required to eradicate the FDC reservoir of HIV-1 are insensitive to the number of virions bound and their degree of attachment to FDC before treatment. In contrast, the expected time required for dissociation of an individual virion from FDC varies sensitively with the number of ligands attached to the virion that are available to interact with receptors on FDC. Although most virions may dissociate from FDC on the time scale of days to weeks, virions coupled to a higher-than-average number of ligands may persist on FDC for years. This result suggests that HAART may not be able to clear all HIV-1 trapped on FDC and that, even if clearance is possible, years of treatment will be required." @default.
• W2150740586 created "2016-06-24" @default.
• W2150740586 creator A5016126519 @default.
• W2150740586 creator A5058338534 @default.
• W2150740586 creator A5090993633 @default.
• W2150740586 date "1999-12-21" @default.
• W2150740586 modified "2023-09-23" @default.
• W2150740586 title "Dissociation of HIV-1 from follicular dendritic cells during HAART: Mathematical analysis" @default.
• W2150740586 cites W1462658072 @default.
• W2150740586 cites W1486583343 @default.
• W2150740586 cites W1499309587 @default.
• W2150740586 cites W1500833770 @default.
• W2150740586 cites W1526389706 @default.
• W2150740586 cites W1550154089 @default.
• W2150740586 cites W1782468444 @default.
• W2150740586 cites W1912744811 @default.
• W2150740586 cites W1950966714 @default.
• W2150740586 cites W1969412508 @default.
• W2150740586 cites W1976828027 @default.
• W2150740586 cites W1983829372 @default.
• W2150740586 cites W1985578054 @default.
• W2150740586 cites W1988140844 @default.
• W2150740586 cites W1994476715 @default.
• W2150740586 cites W1995355944 @default.
• W2150740586 cites W1995548818 @default.
• W2150740586 cites W1998537145 @default.
• W2150740586 cites W2000996966 @default.
• W2150740586 cites W2024534168 @default.
• W2150740586 cites W2031037912 @default.
• W2150740586 cites W2035862895 @default.
• W2150740586 cites W2036362341 @default.
• W2150740586 cites W2055594353 @default.
• W2150740586 cites W2060146121 @default.
• W2150740586 cites W2062937938 @default.
• W2150740586 cites W2065608903 @default.
• W2150740586 cites W2075135942 @default.
• W2150740586 cites W2079811425 @default.
• W2150740586 cites W2080283280 @default.
• W2150740586 cites W2086209569 @default.
• W2150740586 cites W2104978149 @default.
• W2150740586 cites W2114654929 @default.
• W2150740586 cites W2143956658 @default.
• W2150740586 cites W2156878407 @default.
• W2150740586 cites W2159397388 @default.
• W2150740586 cites W2163223098 @default.
• W2150740586 cites W2248336029 @default.
• W2150740586 cites W2319657764 @default.
• W2150740586 cites W2324551017 @default.
• W2150740586 cites W2470581892 @default.
• W2150740586 cites W9008001 @default.
• W2150740586 doi "https://doi.org/10.1073/pnas.96.26.14681" @default.
• W2150740586 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/24707" @default.
• W2150740586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10611272" @default.
• W2150740586 hasPublicationYear "1999" @default.
• W2150740586 type Work @default.
• W2150740586 sameAs 2150740586 @default.
• W2150740586 citedByCount "69" @default.
• W2150740586 countsByYear W21507405862012 @default.
• W2150740586 countsByYear W21507405862013 @default.
• W2150740586 countsByYear W21507405862014 @default.
• W2150740586 countsByYear W21507405862015 @default.
• W2150740586 countsByYear W21507405862016 @default.
• W2150740586 countsByYear W21507405862017 @default.
• W2150740586 countsByYear W21507405862018 @default.
• W2150740586 countsByYear W21507405862019 @default.
• W2150740586 countsByYear W21507405862020 @default.
• W2150740586 crossrefType "journal-article" @default.
• W2150740586 hasAuthorship W2150740586A5016126519 @default.
• W2150740586 hasAuthorship W2150740586A5058338534 @default.
• W2150740586 hasAuthorship W2150740586A5090993633 @default.
• W2150740586 hasBestOaLocation W21507405861 @default.
• W2150740586 hasConcept C102931765 @default.
• W2150740586 hasConcept C116569031 @default.
• W2150740586 hasConcept C126894567 @default.
• W2150740586 hasConcept C134018914 @default.
• W2150740586 hasConcept C138944611 @default.
• W2150740586 hasConcept C142462285 @default.
• W2150740586 hasConcept C147789679 @default.
• W2150740586 hasConcept C154317977 @default.
• W2150740586 hasConcept C159047783 @default.
• W2150740586 hasConcept C170493617 @default.
• W2150740586 hasConcept C185592680 @default.
• W2150740586 hasConcept C187785154 @default.
• W2150740586 hasConcept C202751555 @default.
• W2150740586 hasConcept C2522874641 @default.
• W2150740586 hasConcept C2779712033 @default.
• W2150740586 hasConcept C2993143319 @default.
• W2150740586 hasConcept C3013748606 @default.
• W2150740586 hasConcept C3753494 @default.
• W2150740586 hasConcept C55493867 @default.
• W2150740586 hasConcept C67662055 @default.
• W2150740586 hasConcept C71924100 @default.
• W2150740586 hasConcept C86803240 @default.
• W2150740586 hasConceptScore W2150740586C102931765 @default.
• W2150740586 hasConceptScore W2150740586C116569031 @default.
• W2150740586 hasConceptScore W2150740586C126894567 @default.
• W2150740586 hasConceptScore W2150740586C134018914 @default.
• W2150740586 hasConceptScore W2150740586C138944611 @default.

• next