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- W2150768950 abstract "Cardiolipin (CL) and β2-Glycoprotein I (β2-GpI) antibodies have been shown to associate with various neurological symptoms including seizures and cognitive dysfunction. Here we studied the prevalence of CL, β2-GpI and antinuclear (ANA) antibodies in 74 patients with various developmental disorders with epilepsy and 70 healthy controls. Developmental disorders were classified into genetic syndromes and diseases, genetic and/or acquired conditions, cortical dysgenesias and acquired encephalopathias. IgM-CL and β2-GpI antibodies were significantly more common in patients (46% vs. 20%, p < 0.001 and 10% vs. 0%, p < 0.05). Patients with most frequent seizures were more likely to have IgM-CL antibodies. The risk for positive IgM-CL, IgG-CL and β2-GpI antibodies increased concomitantly with increasing intellectual disability. Present data demonstrates that epilepsy with frequently recurring seizures may be associated with secondary immune system activation." @default.
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- W2150768950 date "2011-07-01" @default.
- W2150768950 modified "2023-10-16" @default.
- W2150768950 title "Cardiolipin and β2-Glycoprotein I antibodies associate with cognitive impairment and seizure frequency in developmental disorders" @default.
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- W2150768950 doi "https://doi.org/10.1016/j.seizure.2011.01.018" @default.
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