FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150801318> ?p ?o ?g. }

• W2150801318 endingPage "1323" @default.
• W2150801318 startingPage "1311" @default.
• W2150801318 abstract "All mammalian uteri contain endometrial glands that synthesize or transport and secrete substances essential for survival and development of the conceptus (embryo/fetus and associated extraembryonic membranes). In rodents, uterine secretory products of the endometrial glands are unequivocally required for establishment of uterine receptivity and conceptus implantation. Analyses of the ovine uterine gland knockout model support a primary role for endometrial glands and, by default, their secretions in peri-implantation conceptus survival and development. Uterine adenogenesis is the process whereby endometrial glands develop. In humans, this process begins in the fetus, continues postnatally, and is completed during puberty. In contrast, endometrial adenogenesis is primarily a postnatal event in sheep, pigs, and rodents. Typically, endometrial adenogenesis involves differentiation and budding of glandular epithelium from luminal epithelium, followed by invagination and extensive tubular coiling and branching morphogenesis throughout the uterine stroma to the myometrium. This process requires site-specific alterations in cell proliferation and extracellular matrix (ECM) remodeling as well as paracrine cell-cell and cell-ECM interactions that support the actions of specific hormones and growth factors. Studies of uterine development in neonatal ungulates implicate prolactin, estradiol-17β, and their receptors in mechanisms regulating endometrial adenogenesis. These same hormones appear to regulate endometrial gland morphogenesis in menstruating primates and humans during reconstruction of the functionalis from the basalis endometrium after menses. In sheep and pigs, extensive endometrial gland hyperplasia and hypertrophy occur during gestation, presumably to provide increasing histotrophic support for conceptus growth and development. In the rabbit, sheep, and pig, a servomechanism is proposed to regulate endometrial gland development and differentiated function during pregnancy that involves sequential actions of ovarian steroid hormones, pregnancy recognition signals, and lactogenic hormones from the pituitary or placenta. That disruption of uterine development during critical organizational periods can alter the functional capacity and embryotrophic potential of the adult uterus reinforces the importance of understanding the developmental biology of uterine glands. Unexplained high rates of peri-implantation embryonic loss in humans and livestock may reflect defects in endometrial gland morphogenesis due to genetic errors, epigenetic influences of endocrine disruptors, and pathological lesions." @default.
• W2150801318 created "2016-06-24" @default.
• W2150801318 creator A5002619546 @default.
• W2150801318 creator A5016398070 @default.
• W2150801318 creator A5016824229 @default.
• W2150801318 creator A5021286537 @default.
• W2150801318 creator A5053559421 @default.
• W2150801318 creator A5076315257 @default.
• W2150801318 creator A5081305948 @default.
• W2150801318 date "2001-11-01" @default.
• W2150801318 modified "2023-10-13" @default.
• W2150801318 title "Developmental Biology of Uterine Glands1" @default.
• W2150801318 cites W103212915 @default.
• W2150801318 cites W1451684643 @default.
• W2150801318 cites W1519147104 @default.
• W2150801318 cites W1964847244 @default.
• W2150801318 cites W1965675319 @default.
• W2150801318 cites W1966488185 @default.
• W2150801318 cites W1971598640 @default.
• W2150801318 cites W1978538506 @default.
• W2150801318 cites W1982923389 @default.
• W2150801318 cites W1982990560 @default.
• W2150801318 cites W1984386950 @default.
• W2150801318 cites W1984842799 @default.
• W2150801318 cites W1985080991 @default.
• W2150801318 cites W1987848957 @default.
• W2150801318 cites W1988928994 @default.
• W2150801318 cites W1994780917 @default.
• W2150801318 cites W2002418365 @default.
• W2150801318 cites W2002569347 @default.
• W2150801318 cites W2002646580 @default.
• W2150801318 cites W2004940237 @default.
• W2150801318 cites W2005276620 @default.
• W2150801318 cites W2007567229 @default.
• W2150801318 cites W2008241182 @default.
• W2150801318 cites W2010644501 @default.
• W2150801318 cites W2015604732 @default.
• W2150801318 cites W2017124406 @default.
• W2150801318 cites W2028720845 @default.
• W2150801318 cites W2030601224 @default.
• W2150801318 cites W2030676116 @default.
• W2150801318 cites W2032765678 @default.
• W2150801318 cites W2035315975 @default.
• W2150801318 cites W2038408915 @default.
• W2150801318 cites W2038507723 @default.
• W2150801318 cites W2041081452 @default.
• W2150801318 cites W2043514435 @default.
• W2150801318 cites W2044679654 @default.
• W2150801318 cites W2054278011 @default.
• W2150801318 cites W2059432771 @default.
• W2150801318 cites W2059513274 @default.
• W2150801318 cites W2060031021 @default.
• W2150801318 cites W2061717044 @default.
• W2150801318 cites W2062647027 @default.
• W2150801318 cites W2063085560 @default.
• W2150801318 cites W2065643273 @default.
• W2150801318 cites W2069467785 @default.
• W2150801318 cites W2069550632 @default.
• W2150801318 cites W2069862542 @default.
• W2150801318 cites W2072680267 @default.
• W2150801318 cites W2077285600 @default.
• W2150801318 cites W2078904893 @default.
• W2150801318 cites W2085603542 @default.
• W2150801318 cites W2086200882 @default.
• W2150801318 cites W2088435676 @default.
• W2150801318 cites W2090500747 @default.
• W2150801318 cites W2091005988 @default.
• W2150801318 cites W2093589111 @default.
• W2150801318 cites W2097469040 @default.
• W2150801318 cites W2098884648 @default.
• W2150801318 cites W2100215658 @default.
• W2150801318 cites W2106489135 @default.
• W2150801318 cites W2107342320 @default.
• W2150801318 cites W2108023376 @default.
• W2150801318 cites W2109894904 @default.
• W2150801318 cites W2110042849 @default.
• W2150801318 cites W2112942779 @default.
• W2150801318 cites W2113045327 @default.
• W2150801318 cites W2113103296 @default.
• W2150801318 cites W2114069082 @default.
• W2150801318 cites W2115537559 @default.
• W2150801318 cites W2119110607 @default.
• W2150801318 cites W2119424482 @default.
• W2150801318 cites W2120287431 @default.
• W2150801318 cites W2123688752 @default.
• W2150801318 cites W2124174994 @default.
• W2150801318 cites W2128333685 @default.
• W2150801318 cites W2128634625 @default.
• W2150801318 cites W2136359610 @default.
• W2150801318 cites W2136960342 @default.
• W2150801318 cites W2138142695 @default.
• W2150801318 cites W2138354687 @default.
• W2150801318 cites W2138605811 @default.
• W2150801318 cites W2140054356 @default.
• W2150801318 cites W2140864453 @default.
• W2150801318 cites W2141192803 @default.
• W2150801318 cites W2141269411 @default.
• W2150801318 cites W2141802887 @default.

• next