Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150821966> ?p ?o ?g. }
- W2150821966 abstract "Deregulation of Polycomb member Bmi-1 is involved in cell proliferation and human oncogenesis. Modulation of Bmi-1 is found in several tumor tissues, including primary breast carcinomas; however, analysis of Bmi-1 in plasma of cancer patients has not been reported. This is the first study that evaluates Bmi-1 in plasma by using a large series of primary breast carcinomas to investigate the presence at diagnosis of detectable Bmi-1 mRNA in plasma and possible correlations between this event and a series of clinical-pathological parameters of the tumors.Bmi-1 expression levels were quantified in plasma of 111 breast cancer patients and in 20 healthy controls by real-time quantitative polymerase chain reaction.Cancer patients with the presence of Bmi-1 mRNA in plasma had higher levels of Bmi-1 expression than healthy controls with Bmi-1 mRNA in plasma. The higher expression levels of Bmi-1 correlated with well-established markers of poor clinical outcome in breast cancer such as positive p53 immunostaining and negative progesterone receptors. Moreover, we described for the first time a statistically significant correlation between Bmi-1 expression in plasma of breast cancer patients and disease-free and overall survival in advanced stages.Our results suggest that levels of Bmi-1 expression may be a surrogate marker of poor prognosis and may become clinically useful as noninvasive diagnostic markers." @default.
- W2150821966 created "2016-06-24" @default.
- W2150821966 creator A5006498199 @default.
- W2150821966 creator A5008409708 @default.
- W2150821966 creator A5013768256 @default.
- W2150821966 creator A5017394034 @default.
- W2150821966 creator A5031206323 @default.
- W2150821966 creator A5043033718 @default.
- W2150821966 creator A5053190947 @default.
- W2150821966 creator A5056169925 @default.
- W2150821966 creator A5071880493 @default.
- W2150821966 creator A5089196434 @default.
- W2150821966 date "2007-08-01" @default.
- W2150821966 modified "2023-10-15" @default.
- W2150821966 title "Circulating Bmi-1 mRNA as a possible prognostic factor for advanced breast cancer patients" @default.
- W2150821966 cites W1481473039 @default.
- W2150821966 cites W1533586432 @default.
- W2150821966 cites W1550107968 @default.
- W2150821966 cites W1849446486 @default.
- W2150821966 cites W1948348012 @default.
- W2150821966 cites W1964975433 @default.
- W2150821966 cites W1967293175 @default.
- W2150821966 cites W1968331471 @default.
- W2150821966 cites W1993240075 @default.
- W2150821966 cites W1994470514 @default.
- W2150821966 cites W1994974515 @default.
- W2150821966 cites W2008797552 @default.
- W2150821966 cites W2022557585 @default.
- W2150821966 cites W2034375133 @default.
- W2150821966 cites W2036713409 @default.
- W2150821966 cites W2042563950 @default.
- W2150821966 cites W2052681228 @default.
- W2150821966 cites W2052849602 @default.
- W2150821966 cites W2062759109 @default.
- W2150821966 cites W2069786312 @default.
- W2150821966 cites W2086484244 @default.
- W2150821966 cites W2096088000 @default.
- W2150821966 cites W2097166664 @default.
- W2150821966 cites W2103362277 @default.
- W2150821966 cites W2104442483 @default.
- W2150821966 cites W2105298978 @default.
- W2150821966 cites W2106548070 @default.
- W2150821966 cites W2108977725 @default.
- W2150821966 cites W2114473143 @default.
- W2150821966 cites W2116905005 @default.
- W2150821966 cites W2123309994 @default.
- W2150821966 cites W2124153379 @default.
- W2150821966 cites W2135674966 @default.
- W2150821966 cites W2135739626 @default.
- W2150821966 cites W2136080892 @default.
- W2150821966 cites W2143490693 @default.
- W2150821966 cites W2145422594 @default.
- W2150821966 cites W2145603992 @default.
- W2150821966 cites W2149847118 @default.
- W2150821966 cites W2151163394 @default.
- W2150821966 cites W2151598146 @default.
- W2150821966 cites W2157429768 @default.
- W2150821966 cites W2165603335 @default.
- W2150821966 doi "https://doi.org/10.1186/bcr1760" @default.
- W2150821966 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2206731" @default.
- W2150821966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17711569" @default.
- W2150821966 hasPublicationYear "2007" @default.
- W2150821966 type Work @default.
- W2150821966 sameAs 2150821966 @default.
- W2150821966 citedByCount "79" @default.
- W2150821966 countsByYear W21508219662012 @default.
- W2150821966 countsByYear W21508219662013 @default.
- W2150821966 countsByYear W21508219662014 @default.
- W2150821966 countsByYear W21508219662015 @default.
- W2150821966 countsByYear W21508219662016 @default.
- W2150821966 countsByYear W21508219662017 @default.
- W2150821966 countsByYear W21508219662018 @default.
- W2150821966 countsByYear W21508219662019 @default.
- W2150821966 countsByYear W21508219662020 @default.
- W2150821966 countsByYear W21508219662021 @default.
- W2150821966 countsByYear W21508219662022 @default.
- W2150821966 countsByYear W21508219662023 @default.
- W2150821966 crossrefType "journal-article" @default.
- W2150821966 hasAuthorship W2150821966A5006498199 @default.
- W2150821966 hasAuthorship W2150821966A5008409708 @default.
- W2150821966 hasAuthorship W2150821966A5013768256 @default.
- W2150821966 hasAuthorship W2150821966A5017394034 @default.
- W2150821966 hasAuthorship W2150821966A5031206323 @default.
- W2150821966 hasAuthorship W2150821966A5043033718 @default.
- W2150821966 hasAuthorship W2150821966A5053190947 @default.
- W2150821966 hasAuthorship W2150821966A5056169925 @default.
- W2150821966 hasAuthorship W2150821966A5071880493 @default.
- W2150821966 hasAuthorship W2150821966A5089196434 @default.
- W2150821966 hasBestOaLocation W21508219661 @default.
- W2150821966 hasConcept C121608353 @default.
- W2150821966 hasConcept C126322002 @default.
- W2150821966 hasConcept C142724271 @default.
- W2150821966 hasConcept C143998085 @default.
- W2150821966 hasConcept C2779399171 @default.
- W2150821966 hasConcept C2780140570 @default.
- W2150821966 hasConcept C2780221984 @default.
- W2150821966 hasConcept C530470458 @default.
- W2150821966 hasConcept C555283112 @default.
- W2150821966 hasConcept C71924100 @default.
- W2150821966 hasConceptScore W2150821966C121608353 @default.