FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150822446> ?p ?o ?g. }

• W2150822446 endingPage "935" @default.
• W2150822446 startingPage "923" @default.
• W2150822446 abstract "New molecules of benzimidazole endowed with oxadiazole were designed and synthesized from 2‐(2‐((pyrimidin‐2‐ylthio)methyl)‐1 H ‐benzo[ d ]imidazol‐1‐yl)acetohydrazide as 1‐((5‐substituted alkyl/aryl‐1,3,4‐oxadiazol‐2‐yl)methyl)‐2‐((pyrimidin‐2‐ylthio)methyl)‐1 H ‐benzimidazoles ( 5a – r ) with the aim to acquire selective cyclooxygenase (COX‐2) inhibitor activity. The synthesized compounds were screened by in vitro cyclooxygenase assays to determine COX‐1 and COX‐2 inhibitory potency and the results showed that they had good‐to‐remarkable activity with an IC 50 range of 11.6–56.1 µM. The most active compounds were further screened for their in vivo anti‐inflammatory activity by using the carrageenan‐induced rat paw edema model. In vitro anticancer activities of the hybrid compounds were assessed by the National Cancer Institute (NCI), USA, against 60 human cell lines, and the results showed a good spectrum. Compound 5l exhibited significant COX‐2 inhibition with an IC 50 value of 8.2 µM and a percent protection of 68.4%. Compound 5b evinced moderate cytotoxicity toward the UO‐31 cell line of renal cancer. A docking study was performed using Maestro 9.0, to provide the binding mode into the binding sites of the cyclooxygenase enzyme. Hopefully, in the future, compound 5l could serve as a lead compound for developing new COX‐2 inhibitors." @default.
• W2150822446 created "2016-06-24" @default.
• W2150822446 creator A5056986587 @default.
• W2150822446 creator A5064803665 @default.
• W2150822446 creator A5085471041 @default.
• W2150822446 creator A5085493222 @default.
• W2150822446 creator A5089822951 @default.
• W2150822446 date "2014-10-09" @default.
• W2150822446 modified "2023-10-16" @default.
• W2150822446 title "Design and Synthesis of Benzimidazole Analogs Endowed with Oxadiazole as Selective COX-2 Inhibitor" @default.
• W2150822446 cites W1965617737 @default.
• W2150822446 cites W1967683469 @default.
• W2150822446 cites W1967814352 @default.
• W2150822446 cites W1970473158 @default.
• W2150822446 cites W1971605286 @default.
• W2150822446 cites W1974222274 @default.
• W2150822446 cites W1981736539 @default.
• W2150822446 cites W1981819970 @default.
• W2150822446 cites W1983310681 @default.
• W2150822446 cites W1986160028 @default.
• W2150822446 cites W1990392207 @default.
• W2150822446 cites W1998545166 @default.
• W2150822446 cites W2003465771 @default.
• W2150822446 cites W2003520488 @default.
• W2150822446 cites W2003684583 @default.
• W2150822446 cites W2006577697 @default.
• W2150822446 cites W2015101218 @default.
• W2150822446 cites W2022114195 @default.
• W2150822446 cites W2030850720 @default.
• W2150822446 cites W2040380614 @default.
• W2150822446 cites W2047142196 @default.
• W2150822446 cites W2053500472 @default.
• W2150822446 cites W2055622791 @default.
• W2150822446 cites W2060198845 @default.
• W2150822446 cites W2070868273 @default.
• W2150822446 cites W2079589739 @default.
• W2150822446 cites W2106607260 @default.
• W2150822446 cites W2117227343 @default.
• W2150822446 cites W2119689902 @default.
• W2150822446 cites W2122520739 @default.
• W2150822446 cites W2125471714 @default.
• W2150822446 cites W2147906616 @default.
• W2150822446 cites W2151962105 @default.
• W2150822446 cites W2159340054 @default.
• W2150822446 cites W2175918357 @default.
• W2150822446 doi "https://doi.org/10.1002/ardp.201400219" @default.
• W2150822446 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25303727" @default.
• W2150822446 hasPublicationYear "2014" @default.
• W2150822446 type Work @default.
• W2150822446 sameAs 2150822446 @default.
• W2150822446 citedByCount "21" @default.
• W2150822446 countsByYear W21508224462015 @default.
• W2150822446 countsByYear W21508224462016 @default.
• W2150822446 countsByYear W21508224462017 @default.
• W2150822446 countsByYear W21508224462018 @default.
• W2150822446 countsByYear W21508224462019 @default.
• W2150822446 countsByYear W21508224462020 @default.
• W2150822446 countsByYear W21508224462021 @default.
• W2150822446 countsByYear W21508224462022 @default.
• W2150822446 countsByYear W21508224462023 @default.
• W2150822446 crossrefType "journal-article" @default.
• W2150822446 hasAuthorship W2150822446A5056986587 @default.
• W2150822446 hasAuthorship W2150822446A5064803665 @default.
• W2150822446 hasAuthorship W2150822446A5085471041 @default.
• W2150822446 hasAuthorship W2150822446A5085493222 @default.
• W2150822446 hasAuthorship W2150822446A5089822951 @default.
• W2150822446 hasConcept C109316439 @default.
• W2150822446 hasConcept C150903083 @default.
• W2150822446 hasConcept C159110408 @default.
• W2150822446 hasConcept C178790620 @default.
• W2150822446 hasConcept C181199279 @default.
• W2150822446 hasConcept C185592680 @default.
• W2150822446 hasConcept C202751555 @default.
• W2150822446 hasConcept C207001950 @default.
• W2150822446 hasConcept C2777752112 @default.
• W2150822446 hasConcept C2778484023 @default.
• W2150822446 hasConcept C2779448499 @default.
• W2150822446 hasConcept C2779689624 @default.
• W2150822446 hasConcept C2780263894 @default.
• W2150822446 hasConcept C2781076698 @default.
• W2150822446 hasConcept C2781227287 @default.
• W2150822446 hasConcept C41685203 @default.
• W2150822446 hasConcept C54355233 @default.
• W2150822446 hasConcept C55493867 @default.
• W2150822446 hasConcept C57992300 @default.
• W2150822446 hasConcept C71240020 @default.
• W2150822446 hasConcept C71924100 @default.
• W2150822446 hasConcept C81885089 @default.
• W2150822446 hasConcept C86803240 @default.
• W2150822446 hasConcept C98274493 @default.
• W2150822446 hasConceptScore W2150822446C109316439 @default.
• W2150822446 hasConceptScore W2150822446C150903083 @default.
• W2150822446 hasConceptScore W2150822446C159110408 @default.
• W2150822446 hasConceptScore W2150822446C178790620 @default.
• W2150822446 hasConceptScore W2150822446C181199279 @default.
• W2150822446 hasConceptScore W2150822446C185592680 @default.
• W2150822446 hasConceptScore W2150822446C202751555 @default.
• W2150822446 hasConceptScore W2150822446C207001950 @default.

• next