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• W2150833075 abstract "<h3>BACKGROUND:</h3> When supplemental oxygen is added to noninvasive ventilation using a non-ICU ventilator, it is usually introduced with a preset flow into the circuit near the ventilator; however, the impact of different CO₂ exhalation systems and leaks on the actual F_IO₂ and gas exchange has not been elucidated. <h3>METHODS:</h3> In a randomized, open-label, 4-treatment (2-by-2), 4-period crossover design, 4 daytime measurements (60 min each) were performed in 20 subjects receiving home mechanical noninvasive ventilation plus supplemental oxygen (≥ 2 L/min) inserted near the ventilator: active valve circuit or leak port circuit with or without artificial leakage (4 mm inner diameter). Oxygen concentration near the ventilator, oxygen concentration at the mask, and blood gases were measured. <h3>RESULTS:</h3> Overall, oxygen concentration at the mask (29 ± 5%) was lower than oxygen concentration at the ventilator (34 ± 4%), with a mean difference of 5.1% (95% CI 4.2–5.9%, <i>P</i> < .001)%. With the leak port circuit, oxygen concentration at the mask decreased by 3.2% (95% CI 2.6 to 3.9%, <i>P</i> < .001), compared to the active valve circuit. When artificial leakage was introduced into the circuit, oxygen concentration at the mask decreased by 5.7% (95% CI 5.1 to 6.4%, <i>P</i> < .001)%, P_aO₂ by 10.4 mm Hg (95% CI 3.1 to 17.7 mm Hg, <i>P</i> = .006), and P_aCO₂ increased by 1.8 mm Hg (95% CI 0.5 to 3.1 mm Hg, <i>P</i> = .008). <h3>CONCLUSIONS:</h3> The use of a leak port circuit and the occurrence of leak around the interface significantly reduced oxygen concentration at the mask and negatively impacted gas exchange in subjects receiving home noninvasive ventilation and supplemental oxygen. (German Clinical Trials Registry, www.drks.de, DRKS00000449)." @default.
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• W2150833075 date "2013-06-25" @default.
• W2150833075 modified "2023-10-02" @default.
• W2150833075 title "Oxygen Supplementation in Noninvasive Home Mechanical Ventilation: The Crucial Roles of CO₂Exhalation Systems and Leakages" @default.
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• W2150833075 doi "https://doi.org/10.4187/respcare.02596" @default.
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