FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150839624> ?p ?o ?g. }

• W2150839624 endingPage "10130" @default.
• W2150839624 startingPage "10121" @default.
• W2150839624 abstract "ABSTRACT We examined properties of the innate immune response against the tumor-specific antigen simian virus 40 (SV40) large tumor antigen (Tag) following experimental pulmonary metastasis in naive mice. Approximately 14 days after mKSA tumor cell challenge, expression of inflammatory mediators such as tumor necrosis factor alpha (TNF-α), interleukin-2 (IL-2), and RANTES was upregulated in splenocytes harvested from mice, as assessed by flow cytometry and antibody array assays. This response was hypothesized to activate and induce tumor-directed NK cell lysis since IL-2-stimulated NK cells mediated tumor cell destruction in vitro . The necessary function of NK cells was further validated in vivo through selected antibody depletion of NK cells, which resulted in an overwhelming lung tumor burden relative to that in animals receiving a control rabbit IgG depletion regimen. Interestingly, mice achieved increased protection from experimental pulmonary metastasis when NK cells were further activated indirectly through in vivo administration of poly(I:C), a Toll-like receptor 3 (TLR3) agonist. In a separate study, mice receiving treatments of poly(I:C) and recombinant SV40 Tag protein immunization mounted effective tumor immunity in an established experimental pulmonary metastasis setting. Initiating broad-based immunity with poly(I:C) was observed to induce a Th1 bias in the SV40 Tag antibody response that led to successful antitumor responses not observed in animals treated only with poly(I:C) or SV40 Tag. These data have direct implications for immunotherapeutic strategies incorporating methods to elicit inflammatory reactions, particularly NK cell-driven lysis, against malignant cell types that express a tumor-specific antigen such as SV40 Tag." @default.
• W2150839624 created "2016-06-24" @default.
• W2150839624 creator A5020909670 @default.
• W2150839624 creator A5034397282 @default.
• W2150839624 creator A5050022897 @default.
• W2150839624 creator A5068076273 @default.
• W2150839624 creator A5070776549 @default.
• W2150839624 creator A5079497490 @default.
• W2150839624 date "2010-10-01" @default.
• W2150839624 modified "2023-10-16" @default.
• W2150839624 title "Role of the Innate Immune Response and Tumor Immunity Associated with Simian Virus 40 Large Tumor Antigen" @default.
• W2150839624 cites W1541041711 @default.
• W2150839624 cites W1585397838 @default.
• W2150839624 cites W1592969536 @default.
• W2150839624 cites W1792358390 @default.
• W2150839624 cites W1963949170 @default.
• W2150839624 cites W1965917728 @default.
• W2150839624 cites W1969354039 @default.
• W2150839624 cites W1990113015 @default.
• W2150839624 cites W1999476100 @default.
• W2150839624 cites W2000813547 @default.
• W2150839624 cites W2012129419 @default.
• W2150839624 cites W2015556752 @default.
• W2150839624 cites W2016708646 @default.
• W2150839624 cites W2019804037 @default.
• W2150839624 cites W2024896474 @default.
• W2150839624 cites W2028036592 @default.
• W2150839624 cites W2030719738 @default.
• W2150839624 cites W2034028219 @default.
• W2150839624 cites W2061262594 @default.
• W2150839624 cites W2061366514 @default.
• W2150839624 cites W2064981157 @default.
• W2150839624 cites W2073292489 @default.
• W2150839624 cites W2078597408 @default.
• W2150839624 cites W2086542713 @default.
• W2150839624 cites W2100262165 @default.
• W2150839624 cites W2107229641 @default.
• W2150839624 cites W2114146420 @default.
• W2150839624 cites W2118278569 @default.
• W2150839624 cites W2163105956 @default.
• W2150839624 cites W4255758041 @default.
• W2150839624 doi "https://doi.org/10.1128/jvi.01095-10" @default.
• W2150839624 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2937757" @default.
• W2150839624 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20668083" @default.
• W2150839624 hasPublicationYear "2010" @default.
• W2150839624 type Work @default.
• W2150839624 sameAs 2150839624 @default.
• W2150839624 citedByCount "11" @default.
• W2150839624 countsByYear W21508396242012 @default.
• W2150839624 countsByYear W21508396242015 @default.
• W2150839624 countsByYear W21508396242016 @default.
• W2150839624 countsByYear W21508396242017 @default.
• W2150839624 crossrefType "journal-article" @default.
• W2150839624 hasAuthorship W2150839624A5020909670 @default.
• W2150839624 hasAuthorship W2150839624A5034397282 @default.
• W2150839624 hasAuthorship W2150839624A5050022897 @default.
• W2150839624 hasAuthorship W2150839624A5068076273 @default.
• W2150839624 hasAuthorship W2150839624A5070776549 @default.
• W2150839624 hasAuthorship W2150839624A5079497490 @default.
• W2150839624 hasBestOaLocation W21508396242 @default.
• W2150839624 hasConcept C121608353 @default.
• W2150839624 hasConcept C136449434 @default.
• W2150839624 hasConcept C147483822 @default.
• W2150839624 hasConcept C149532602 @default.
• W2150839624 hasConcept C154317977 @default.
• W2150839624 hasConcept C159654299 @default.
• W2150839624 hasConcept C17991360 @default.
• W2150839624 hasConcept C202751555 @default.
• W2150839624 hasConcept C203014093 @default.
• W2150839624 hasConcept C2776709828 @default.
• W2150839624 hasConcept C2777701055 @default.
• W2150839624 hasConcept C2778420691 @default.
• W2150839624 hasConcept C2778690821 @default.
• W2150839624 hasConcept C2779013556 @default.
• W2150839624 hasConcept C502942594 @default.
• W2150839624 hasConcept C54355233 @default.
• W2150839624 hasConcept C55493867 @default.
• W2150839624 hasConcept C86803240 @default.
• W2150839624 hasConcept C8891405 @default.
• W2150839624 hasConceptScore W2150839624C121608353 @default.
• W2150839624 hasConceptScore W2150839624C136449434 @default.
• W2150839624 hasConceptScore W2150839624C147483822 @default.
• W2150839624 hasConceptScore W2150839624C149532602 @default.
• W2150839624 hasConceptScore W2150839624C154317977 @default.
• W2150839624 hasConceptScore W2150839624C159654299 @default.
• W2150839624 hasConceptScore W2150839624C17991360 @default.
• W2150839624 hasConceptScore W2150839624C202751555 @default.
• W2150839624 hasConceptScore W2150839624C203014093 @default.
• W2150839624 hasConceptScore W2150839624C2776709828 @default.
• W2150839624 hasConceptScore W2150839624C2777701055 @default.
• W2150839624 hasConceptScore W2150839624C2778420691 @default.
• W2150839624 hasConceptScore W2150839624C2778690821 @default.
• W2150839624 hasConceptScore W2150839624C2779013556 @default.
• W2150839624 hasConceptScore W2150839624C502942594 @default.
• W2150839624 hasConceptScore W2150839624C54355233 @default.
• W2150839624 hasConceptScore W2150839624C55493867 @default.
• W2150839624 hasConceptScore W2150839624C86803240 @default.
• W2150839624 hasConceptScore W2150839624C8891405 @default.

• next