Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150850571> ?p ?o ?g. }
- W2150850571 endingPage "500" @default.
- W2150850571 startingPage "483" @default.
- W2150850571 abstract "Microtubule-targeted anticancer drugs are effective in treating various cancers but are limited in use due to development of resistance and unacceptable toxicities. The epothilones are a novel class of microtubule-stabilizing anticancer drugs and may have a role in treating taxane-resistant cancers. Revised and updated data from several clinical studies for ixabepilone were recently published and subsequently resulted in ixabepilone becoming the first epothilone approved as monotherapy or in combination for treatment of locally advanced or metastatic breast cancer. BMS-310705, patupilone, KOS-862, KOS-1584 and ZK-EPO are epothilones that have been developed. Although peripheral sensory neuropathy and neutropenia are the dose-limiting toxicities for ixabepilone, these dose-limiting toxicities are ixabepilone specific. This review will discuss the current preclinical, clinical pharmacokinetic and pharmacodynamic, efficacy and toxicity data of the epothilones." @default.
- W2150850571 created "2016-06-24" @default.
- W2150850571 creator A5007599167 @default.
- W2150850571 creator A5021199033 @default.
- W2150850571 creator A5044880752 @default.
- W2150850571 creator A5052584121 @default.
- W2150850571 creator A5063845737 @default.
- W2150850571 date "2008-08-01" @default.
- W2150850571 modified "2023-09-27" @default.
- W2150850571 title "Epothilones: a novel class of microtubule-stabilizing drugs for the treatment of cancer" @default.
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