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• W2150870081 abstract "A novel series of achiral TNF-α converting enzyme (TACE) inhibitors has been discovered. These compounds exhibited activities from 0.35 to 11 nM in a porcine TACE assay and inhibited TNF-α production in an LPS-stimulated whole blood assay with an IC50 value of 23 nM for the most potent one. They also have excellent selectivities over related metalloproteases including aggrecanases." @default.
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• W2150870081 date "2006-05-01" @default.
• W2150870081 modified "2023-10-11" @default.
• W2150870081 title "Synthesis and structure–activity relationship of a novel, achiral series of TNF-α converting enzyme inhibitors" @default.
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• W2150870081 doi "https://doi.org/10.1016/j.bmcl.2006.02.015" @default.
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