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- W2150871836 abstract "Space missions beyond the protection of Earth's magnetosphere expose astronauts to an environment that contains ionizing proton radiation. The hazards that proton radiation pose to normal tissues, such as the central nervous system (CNS), are not fully understood, although it has been shown that proton radiation affects the neurogenic environment, killing neural precursors and altering behavior. To determine the time and dose-response characteristics of the CNS to whole-body proton irradiation, C57BL/6J mice were exposed to 1 GeV/n proton radiation at doses of 0–200 cGy and behavioral, physiological and immunohistochemical end points were analyzed over a range of time points (48 h–12 months) postirradiation. These experiments revealed that proton radiation exposure leads to: 1. an acute decrease in cell division within the dentate gyrus of the hippocampus, with significant differences detected at doses as low as 10 cGy; 2. a persistent effect on proliferation in the subgranular zone, at 1 month postirradiation; 3. a decrease in neurogenesis at doses as low as 50 cGy, at 3 months postirradiation; and 4. a decrease in hippocampal ICAM-1 immunoreactivity at doses as low as 10 cGy, at 1 month postirradiation. The data presented contribute to our understanding of biological responses to whole-body proton radiation and may help reduce uncertainty in the assessment of health risks to astronauts. These findings may also be relevant to clinical proton beam therapy." @default.
- W2150871836 created "2016-06-24" @default.
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- W2150871836 date "2014-06-17" @default.
- W2150871836 modified "2023-10-14" @default.
- W2150871836 title "Central Nervous System Effects of Whole-Body Proton Irradiation" @default.
- W2150871836 cites W1550259431 @default.
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- W2150871836 cites W1556896686 @default.
- W2150871836 cites W1963940970 @default.
- W2150871836 cites W1969305530 @default.
- W2150871836 cites W1969565375 @default.
- W2150871836 cites W1972194998 @default.
- W2150871836 cites W1976007412 @default.
- W2150871836 cites W1977604451 @default.
- W2150871836 cites W1982528484 @default.
- W2150871836 cites W1986346910 @default.
- W2150871836 cites W1989669360 @default.
- W2150871836 cites W1990524383 @default.
- W2150871836 cites W1990981339 @default.
- W2150871836 cites W1999477260 @default.
- W2150871836 cites W2001171907 @default.
- W2150871836 cites W2002812377 @default.
- W2150871836 cites W2004024464 @default.
- W2150871836 cites W2008501852 @default.
- W2150871836 cites W2011207006 @default.
- W2150871836 cites W2011580597 @default.
- W2150871836 cites W2016940326 @default.
- W2150871836 cites W2025487107 @default.
- W2150871836 cites W2026143081 @default.
- W2150871836 cites W2042154782 @default.
- W2150871836 cites W2049966206 @default.
- W2150871836 cites W2050238055 @default.
- W2150871836 cites W2053176712 @default.
- W2150871836 cites W2054025274 @default.
- W2150871836 cites W2054264241 @default.
- W2150871836 cites W2054552572 @default.
- W2150871836 cites W2055301723 @default.
- W2150871836 cites W2055698728 @default.
- W2150871836 cites W2057608998 @default.
- W2150871836 cites W2060011143 @default.
- W2150871836 cites W2063919773 @default.
- W2150871836 cites W2066903058 @default.
- W2150871836 cites W2067856703 @default.
- W2150871836 cites W2068387575 @default.
- W2150871836 cites W2069930429 @default.
- W2150871836 cites W2070794162 @default.
- W2150871836 cites W2071181288 @default.
- W2150871836 cites W2085408461 @default.
- W2150871836 cites W2088604382 @default.
- W2150871836 cites W2089204174 @default.
- W2150871836 cites W2091364814 @default.
- W2150871836 cites W2094522722 @default.
- W2150871836 cites W2097351636 @default.
- W2150871836 cites W2098137179 @default.
- W2150871836 cites W2099250398 @default.
- W2150871836 cites W2100598040 @default.
- W2150871836 cites W2101833366 @default.
- W2150871836 cites W2103223803 @default.
- W2150871836 cites W2103355232 @default.
- W2150871836 cites W2103704610 @default.
- W2150871836 cites W2108461283 @default.
- W2150871836 cites W2113120301 @default.
- W2150871836 cites W2115185744 @default.
- W2150871836 cites W2120810793 @default.
- W2150871836 cites W2122939482 @default.
- W2150871836 cites W2126544250 @default.
- W2150871836 cites W2127621479 @default.
- W2150871836 cites W2129092894 @default.
- W2150871836 cites W2131320161 @default.
- W2150871836 cites W2131414754 @default.
- W2150871836 cites W2132353362 @default.
- W2150871836 cites W2139481908 @default.
- W2150871836 cites W2142414884 @default.
- W2150871836 cites W2145956680 @default.
- W2150871836 cites W2146214094 @default.
- W2150871836 cites W2150738279 @default.
- W2150871836 cites W2151400960 @default.
- W2150871836 cites W2156865179 @default.
- W2150871836 cites W2160071886 @default.
- W2150871836 cites W2164084731 @default.
- W2150871836 cites W2165794159 @default.
- W2150871836 cites W2166192872 @default.
- W2150871836 cites W2166951708 @default.
- W2150871836 cites W2169145097 @default.
- W2150871836 cites W4232755968 @default.
- W2150871836 cites W4243228024 @default.
- W2150871836 cites W4251277328 @default.
- W2150871836 doi "https://doi.org/10.1667/rr13699.1" @default.
- W2150871836 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24937778" @default.
- W2150871836 hasPublicationYear "2014" @default.