FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150872095> ?p ?o ?g. }

• W2150872095 endingPage "668" @default.
• W2150872095 startingPage "659" @default.
• W2150872095 abstract "Myeloid cells differ in their kinetics (long-lived versus short-lived) and localization. This should be taken into account when targeting myeloid cells during neurodegenerative diseases. Microglia are recruited to and cluster around newly formed Aβ plaques, indicating that they are not directly involved in the initial stages of amyloid plaque formation. Microglia are phagocytic cells in the brain equipped with several receptors that play a role in the clearance of Aβ. Downregulation of these immune-receptors results in compromised phagocytotic capacity of microglia. Morphological alterations such as dystrophic (senescent) microglia have been observed in the aged human and AD brain. Emerging data suggest that microglia deteriorate with age and are dysfunctional during AD. Several recent genome-wide association studies (GWAS) in patients with neurodegenerative disorders have shed new light on the brain immune system, suggesting that it plays a pivotal role in disease pathogenesis. Mononuclear phagocytes are blatantly involved in Alzheimer's disease (AD) of the central nervous system (CNS), but the specific functions of resident microglia, perivascular or meningeal macrophages, and circulating myeloid cells have not yet been fully resolved. Next-generation sequencing, high-throughput immune profiling technologies, and novel genetic tools have recently revolutionized the characterization of innate immune responses during AD. These studies advocate selective and non-redundant roles for myeloid subsets, which could be a target for novel disease-modifying therapies in AD. Several recent genome-wide association studies (GWAS) in patients with neurodegenerative disorders have shed new light on the brain immune system, suggesting that it plays a pivotal role in disease pathogenesis. Mononuclear phagocytes are blatantly involved in Alzheimer's disease (AD) of the central nervous system (CNS), but the specific functions of resident microglia, perivascular or meningeal macrophages, and circulating myeloid cells have not yet been fully resolved. Next-generation sequencing, high-throughput immune profiling technologies, and novel genetic tools have recently revolutionized the characterization of innate immune responses during AD. These studies advocate selective and non-redundant roles for myeloid subsets, which could be a target for novel disease-modifying therapies in AD." @default.
• W2150872095 created "2016-06-24" @default.
• W2150872095 creator A5020510395 @default.
• W2150872095 creator A5049953895 @default.
• W2150872095 date "2015-10-01" @default.
• W2150872095 modified "2023-10-17" @default.
• W2150872095 title "Myeloid Cells in Alzheimer's Disease: Culprits, Victims or Innocent Bystanders?" @default.
• W2150872095 cites W1515023627 @default.
• W2150872095 cites W1567490604 @default.
• W2150872095 cites W1581685691 @default.
• W2150872095 cites W1586876258 @default.
• W2150872095 cites W1616122655 @default.
• W2150872095 cites W1617304195 @default.
• W2150872095 cites W1914782230 @default.
• W2150872095 cites W1963968275 @default.
• W2150872095 cites W1964506812 @default.
• W2150872095 cites W1964822121 @default.
• W2150872095 cites W1964944610 @default.
• W2150872095 cites W1966831629 @default.
• W2150872095 cites W1969584460 @default.
• W2150872095 cites W1978314255 @default.
• W2150872095 cites W1978567629 @default.
• W2150872095 cites W1979038308 @default.
• W2150872095 cites W1980825524 @default.
• W2150872095 cites W1981310043 @default.
• W2150872095 cites W1987595364 @default.
• W2150872095 cites W1990636293 @default.
• W2150872095 cites W1990948493 @default.
• W2150872095 cites W1991901467 @default.
• W2150872095 cites W1993976394 @default.
• W2150872095 cites W1994503172 @default.
• W2150872095 cites W1994953714 @default.
• W2150872095 cites W1997245227 @default.
• W2150872095 cites W1997928015 @default.
• W2150872095 cites W1998843397 @default.
• W2150872095 cites W1999952543 @default.
• W2150872095 cites W2003674452 @default.
• W2150872095 cites W2004702150 @default.
• W2150872095 cites W2005586302 @default.
• W2150872095 cites W2009639401 @default.
• W2150872095 cites W2010464023 @default.
• W2150872095 cites W2010876644 @default.
• W2150872095 cites W2011041653 @default.
• W2150872095 cites W2012136117 @default.
• W2150872095 cites W2015867258 @default.
• W2150872095 cites W2018626218 @default.
• W2150872095 cites W2018708829 @default.
• W2150872095 cites W2019574244 @default.
• W2150872095 cites W2019604999 @default.
• W2150872095 cites W2021255508 @default.
• W2150872095 cites W2024304291 @default.
• W2150872095 cites W2025642274 @default.
• W2150872095 cites W2025946388 @default.
• W2150872095 cites W2027430739 @default.
• W2150872095 cites W2029906813 @default.
• W2150872095 cites W2035963355 @default.
• W2150872095 cites W2044090829 @default.
• W2150872095 cites W2045720033 @default.
• W2150872095 cites W2049733399 @default.
• W2150872095 cites W2052652421 @default.
• W2150872095 cites W2055346376 @default.
• W2150872095 cites W2055620105 @default.
• W2150872095 cites W2058669152 @default.
• W2150872095 cites W2066165659 @default.
• W2150872095 cites W2071384955 @default.
• W2150872095 cites W2071695496 @default.
• W2150872095 cites W2071753918 @default.
• W2150872095 cites W2074405990 @default.
• W2150872095 cites W2078675846 @default.
• W2150872095 cites W2079756902 @default.
• W2150872095 cites W2084419295 @default.
• W2150872095 cites W2086752965 @default.
• W2150872095 cites W2086776463 @default.
• W2150872095 cites W2090811490 @default.
• W2150872095 cites W2092411904 @default.
• W2150872095 cites W2092729781 @default.
• W2150872095 cites W2094660330 @default.
• W2150872095 cites W2096500024 @default.
• W2150872095 cites W2096601751 @default.
• W2150872095 cites W2097838704 @default.
• W2150872095 cites W2097867538 @default.
• W2150872095 cites W2098022922 @default.
• W2150872095 cites W2104372589 @default.
• W2150872095 cites W2105385589 @default.
• W2150872095 cites W2106914633 @default.
• W2150872095 cites W2107015337 @default.
• W2150872095 cites W2108689038 @default.
• W2150872095 cites W2112880160 @default.
• W2150872095 cites W2115855931 @default.
• W2150872095 cites W2116784956 @default.
• W2150872095 cites W2119098586 @default.
• W2150872095 cites W2122828560 @default.
• W2150872095 cites W2123047934 @default.
• W2150872095 cites W2124490243 @default.
• W2150872095 cites W2125558391 @default.
• W2150872095 cites W2128613449 @default.
• W2150872095 cites W2128948218 @default.
• W2150872095 cites W2130103159 @default.

• next