FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150872398> ?p ?o ?g. }

• W2150872398 endingPage "285" @default.
• W2150872398 startingPage "267" @default.
• W2150872398 abstract "To characterize antineutrophil cytoplasmic antibodies (ANCA), their major autoantigens, disease associations, and pathophysiology in systemic vasculitides. To describe a patient with a novel de novo ANCA-associated vasculitis after kidney transplantation.We reviewed and compiled the literature on ANCA-related topics and systemic vasculitis. Laboratory and clinical data from a cadaveric kidney transplant patient who developed necrotizing vasculitis involving glomerular capillaries, with crescent formation associated with P-ANCA and myeloperoxidase, were analyzed.Large-scale multi-center testing of patient and normal sera by the European ANCA Assay Standardization Project using immunofluorescence assays and enzyme immunoassays indicate the assays have good sensitivity and specificity, and diagnostic utility for ANCA-associated vasculitis. A few investigations covering basic and clinical research with ANCA remain controversial: whether endothelial cells do or do not express a 29-kd neutral serine protease termed proteinase-3 (PR-3), the target of ANCA in most individuals with Wegener's granulomatosis, and whether anti-myeloperoxidase (MPO) ANCAs recognize a restricted number of epitopes on MPO. This issue has relevance for using monoclonal antibodies to treat patients with vasculitis who have adverse effects from immunosuppressive drugs. The two allelic forms of FcgammaRIIa (H131/R131) and the two of FcgammaRIIlb (NA1/NA2) are discussed as possible inheritable genetic elements for vasculitic disorders and for signaling responses. Stimulatory and costimulatory molecules, and cytokine profiles of T lymphocytes are characterized to show that these cells are actively involved in the ANCA-associated vasculitides. The patient described had a de novo ANCA associated small vessel vasculitis which developed after renal transplantation.There have been significant advances in the development of sensitive and specific ANCA assays. The immunopathogenetic mechanism of ANCA involves the constitutive FcgammaRs, ligands, and signaling responses to activate cytokine-primed neutrophils. This may lead to the generation of reactive oxygen intermediates, degranulation, and secretion of intracellular granule contents, and ultimately inflammation and vasculitis." @default.
• W2150872398 created "2016-06-24" @default.
• W2150872398 creator A5029260967 @default.
• W2150872398 creator A5083099738 @default.
• W2150872398 date "2000-04-01" @default.
• W2150872398 modified "2023-10-18" @default.
• W2150872398 title "Antineutrophil cytoplasmic antibodies (ANCA) and systemicvasculitis: update of assays, immunopathogenesis, controversies, and report of a novel de novo ANCA-associated vasculitis after kidney transplantation" @default.
• W2150872398 cites W1517801283 @default.
• W2150872398 cites W1530177683 @default.
• W2150872398 cites W1539924541 @default.
• W2150872398 cites W1564132479 @default.
• W2150872398 cites W1605823388 @default.
• W2150872398 cites W1608109841 @default.
• W2150872398 cites W1836404011 @default.
• W2150872398 cites W1900762885 @default.
• W2150872398 cites W1967742488 @default.
• W2150872398 cites W1975928268 @default.
• W2150872398 cites W1980066489 @default.
• W2150872398 cites W1982865105 @default.
• W2150872398 cites W1983585840 @default.
• W2150872398 cites W1983626365 @default.
• W2150872398 cites W1985564796 @default.
• W2150872398 cites W1987414591 @default.
• W2150872398 cites W1988376766 @default.
• W2150872398 cites W1990486811 @default.
• W2150872398 cites W1991082568 @default.
• W2150872398 cites W1991911964 @default.
• W2150872398 cites W1994805857 @default.
• W2150872398 cites W1995208224 @default.
• W2150872398 cites W1996477873 @default.
• W2150872398 cites W1997557974 @default.
• W2150872398 cites W1997905155 @default.
• W2150872398 cites W1998496390 @default.
• W2150872398 cites W1998580125 @default.
• W2150872398 cites W1998660890 @default.
• W2150872398 cites W2004055642 @default.
• W2150872398 cites W2007736974 @default.
• W2150872398 cites W2009717210 @default.
• W2150872398 cites W2013965818 @default.
• W2150872398 cites W2014240318 @default.
• W2150872398 cites W2016374131 @default.
• W2150872398 cites W2017316020 @default.
• W2150872398 cites W2017628675 @default.
• W2150872398 cites W2020644012 @default.
• W2150872398 cites W2024864198 @default.
• W2150872398 cites W2026812278 @default.
• W2150872398 cites W2028189322 @default.
• W2150872398 cites W2031168003 @default.
• W2150872398 cites W2032904073 @default.
• W2150872398 cites W2037239628 @default.
• W2150872398 cites W2037892270 @default.
• W2150872398 cites W2039582264 @default.
• W2150872398 cites W2041110206 @default.
• W2150872398 cites W2042103540 @default.
• W2150872398 cites W2045303110 @default.
• W2150872398 cites W2045671838 @default.
• W2150872398 cites W2048148775 @default.
• W2150872398 cites W2049583989 @default.
• W2150872398 cites W2052000810 @default.
• W2150872398 cites W2053142169 @default.
• W2150872398 cites W2056162335 @default.
• W2150872398 cites W2058786503 @default.
• W2150872398 cites W2058863663 @default.
• W2150872398 cites W2062030308 @default.
• W2150872398 cites W2063410888 @default.
• W2150872398 cites W2063964896 @default.
• W2150872398 cites W2064768681 @default.
• W2150872398 cites W2068544809 @default.
• W2150872398 cites W2071083857 @default.
• W2150872398 cites W2072782448 @default.
• W2150872398 cites W2079784078 @default.
• W2150872398 cites W2082775739 @default.
• W2150872398 cites W2083446756 @default.
• W2150872398 cites W2083777349 @default.
• W2150872398 cites W2084162734 @default.
• W2150872398 cites W2084375627 @default.
• W2150872398 cites W2084748765 @default.
• W2150872398 cites W2086684697 @default.
• W2150872398 cites W2087436702 @default.
• W2150872398 cites W2088237595 @default.
• W2150872398 cites W2089888068 @default.
• W2150872398 cites W2091943511 @default.
• W2150872398 cites W2098188700 @default.
• W2150872398 cites W2099675490 @default.
• W2150872398 cites W2100998449 @default.
• W2150872398 cites W2103874411 @default.
• W2150872398 cites W2105621907 @default.
• W2150872398 cites W2109156163 @default.
• W2150872398 cites W2109207289 @default.
• W2150872398 cites W2116619874 @default.
• W2150872398 cites W2117007875 @default.
• W2150872398 cites W2117162099 @default.
• W2150872398 cites W2122953957 @default.
• W2150872398 cites W2130567288 @default.
• W2150872398 cites W2131275770 @default.
• W2150872398 cites W2132495628 @default.
• W2150872398 cites W2135325345 @default.
• W2150872398 cites W2140014095 @default.

• next