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• W2150875653 abstract "Abstract Dysregulation of the central noradrenergic system is a core feature of post‐traumatic stress disorder (PTSD). Here, we examined molecular changes in locus coeruleus ( LC ) triggered by single‐prolonged stress ( SPS ) PTSD model at a time when behavioral symptoms are manifested, and the effect of early intervention with intranasal neuropeptide Y ( NPY ). Immediately following SPS stressors, male SD rats were administered intranasal NPY ( SPS / NPY ) or vehicle ( SPS /V). Seven days later, TH protein, but not mRNA , was elevated in LC only of the SPS /V group. Although 90% of TH positive cells expressed GR , its levels were unaltered. Compared to unstressed controls, LC of SPS /V, but not SPS / NPY , expressed less Y2 receptor mRNA with more CRHR 1 mRNA in subset of animals, and elevated corticotropin‐releasing hormone (CRH) in central nucleus of amygdala. Following testing for anxiety on elevated plus maze (EPM), there were significantly increased TH , DBH and NPY mRNA s in LC of SPS ‐treated, but not previously unstressed animals. Their levels highly correlated with each other but not with behavioral features on EPM. Thus, SPS triggers long‐term noradrenergic activation and higher sensitivity to mild stressors, perhaps mediated by the up‐regulation influence of amygdalar CRH input and down‐regulation of Y2R presynaptic inhibition in LC . Results also demonstrate the therapeutic potential of early intervention with intranasal NPY for traumatic stress‐elicited noradrenergic impairments. image Single‐prolonged stress (SPS)‐triggered long‐term changes in the locus coeruleus/norepinephrine (LC/NE) system with increased tyrosine hydroxylase (TH) protein and CRH receptor 1(CRHR1) mRNA and lower neuropeptide Y receptor 2 (Y2R) mRNA levels as well as elevated corticotropin‐releasing hormone (CRH) in the central nucleus of amygdala (CeA) that were prevented by early intervention with intranasal neuropeptide Y (NPY). SPS treatment led to increased sensitivity of LC to mild stress of elevated plus maze (EPM), with elevated mRNA for NE biosynthetic enzymes in subset of animals." @default.
• W2150875653 created "2016-06-24" @default.
• W2150875653 creator A5031546136 @default.
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• W2150875653 creator A5067263435 @default.
• W2150875653 creator A5087386236 @default.
• W2150875653 date "2015-09-30" @default.
• W2150875653 modified "2023-10-16" @default.
• W2150875653 title "Locus coeruleus response to single‐prolonged stress and early intervention with intranasal neuropeptide Y" @default.
• W2150875653 cites W1479680617 @default.
• W2150875653 cites W1515950061 @default.
• W2150875653 cites W1536317835 @default.
• W2150875653 cites W1571575178 @default.
• W2150875653 cites W1746209842 @default.
• W2150875653 cites W1860512920 @default.
• W2150875653 cites W1897310022 @default.
• W2150875653 cites W1899693127 @default.
• W2150875653 cites W1966557786 @default.
• W2150875653 cites W1968266203 @default.
• W2150875653 cites W1969800465 @default.
• W2150875653 cites W1971899867 @default.
• W2150875653 cites W1982414891 @default.
• W2150875653 cites W1987735575 @default.
• W2150875653 cites W1988954465 @default.
• W2150875653 cites W1991534371 @default.
• W2150875653 cites W1991924547 @default.
• W2150875653 cites W1993545351 @default.
• W2150875653 cites W1998821779 @default.
• W2150875653 cites W2000139014 @default.
• W2150875653 cites W2002299220 @default.
• W2150875653 cites W2008820009 @default.
• W2150875653 cites W2013455001 @default.
• W2150875653 cites W2014415629 @default.
• W2150875653 cites W2015114368 @default.
• W2150875653 cites W2016422638 @default.
• W2150875653 cites W2017833599 @default.
• W2150875653 cites W2019284117 @default.
• W2150875653 cites W2019399329 @default.
• W2150875653 cites W2021393321 @default.
• W2150875653 cites W2023576244 @default.
• W2150875653 cites W2023679577 @default.
• W2150875653 cites W2026279809 @default.
• W2150875653 cites W2029410796 @default.
• W2150875653 cites W2030325164 @default.
• W2150875653 cites W2033842935 @default.
• W2150875653 cites W2034667723 @default.
• W2150875653 cites W2035473397 @default.
• W2150875653 cites W2036304874 @default.
• W2150875653 cites W2041545014 @default.
• W2150875653 cites W2045078990 @default.
• W2150875653 cites W2047872745 @default.
• W2150875653 cites W2051420997 @default.
• W2150875653 cites W2054155432 @default.
• W2150875653 cites W2055447689 @default.
• W2150875653 cites W2055665256 @default.
• W2150875653 cites W2060041930 @default.
• W2150875653 cites W2060594075 @default.
• W2150875653 cites W2064756281 @default.
• W2150875653 cites W2070594067 @default.
• W2150875653 cites W2075645727 @default.
• W2150875653 cites W2076507685 @default.
• W2150875653 cites W2076562119 @default.
• W2150875653 cites W2079311820 @default.
• W2150875653 cites W2080440752 @default.
• W2150875653 cites W2086905464 @default.
• W2150875653 cites W2088117056 @default.
• W2150875653 cites W2088813664 @default.
• W2150875653 cites W2101035000 @default.
• W2150875653 cites W2108067372 @default.
• W2150875653 cites W2109414445 @default.
• W2150875653 cites W2109640419 @default.
• W2150875653 cites W2115095583 @default.
• W2150875653 cites W2117309811 @default.
• W2150875653 cites W2117457874 @default.
• W2150875653 cites W2122005931 @default.
• W2150875653 cites W2134015193 @default.
• W2150875653 cites W2137088792 @default.
• W2150875653 cites W2145082688 @default.
• W2150875653 cites W2152833835 @default.
• W2150875653 cites W2154457951 @default.
• W2150875653 cites W2156948015 @default.
• W2150875653 cites W2159650364 @default.
• W2150875653 cites W2160844797 @default.
• W2150875653 cites W2163115202 @default.
• W2150875653 cites W2168675611 @default.
• W2150875653 doi "https://doi.org/10.1111/jnc.13347" @default.
• W2150875653 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26333000" @default.
• W2150875653 hasPublicationYear "2015" @default.
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