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• W2150876578 endingPage "1136" @default.
• W2150876578 startingPage "1101" @default.
• W2150876578 abstract "The endocannabinoid system (ECS) has been implicated in many physiological functions, including the regulation of appetite, food intake and energy balance, a crucial involvement in brain reward systems and a role in psychophysiological homeostasis (anxiety and stress responses). We first introduce this important regulatory system and chronicle what is known concerning the signal transduction pathways activated upon the binding of endogenous cannabinoid ligands to the Gi/0-coupled CB1 cannabinoid receptor, as well as its interactions with other hormones and neuromodulators which can modify endocannabinoid signaling in the brain. Anorexia nervosa (AN) and bulimia nervosa (BN) are severe and disabling psychiatric disorders, characterized by profound eating and weight alterations and body image disturbances. Since endocannabinoids modulate eating behavior, it is plausible that endocannabinoid genes may contribute to the biological vulnerability to these diseases. We present and discuss data suggesting an impaired endocannabinoid signaling in these eating disorders, including association of endocannabinoid components gene polymorphisms and altered CB1-receptor expression in AN and BN. Then we discuss recent findings that may provide new avenues for the identification of therapeutic strategies based on the endocannabinod system. In relation with its implications as a reward-related system, the endocannabinoid system is not only a target for cannabis but it also shows interactions with other drugs of abuse. On the other hand, there may be also a possibility to point to the ECS as a potential target for treatment of drug-abuse and addiction. Within this framework we will focus on enzymatic machinery involved in endocannabinoid inactivation (notably fatty acid amide hydrolase or FAAH) as a particularly interesting potential target. Since a deregulated endocannabinoid system may be also related to depression, anxiety and pain symptomatology accompanying drug-withdrawal states, this is an area of relevance to also explore adjuvant treatments for improving these adverse emotional reactions." @default.
• W2150876578 created "2016-06-24" @default.
• W2150876578 creator A5019977038 @default.
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• W2150876578 creator A5072676433 @default.
• W2150876578 date "2011-08-10" @default.
• W2150876578 modified "2023-09-30" @default.
• W2150876578 title "The Endocannabinoid System as Pharmacological Target Derived from Its CNS Role in Energy Homeostasis and Reward. Applications in Eating Disorders and Addiction" @default.
• W2150876578 cites W1491109154 @default.
• W2150876578 cites W1492021038 @default.
• W2150876578 cites W1518573356 @default.
• W2150876578 cites W1545631641 @default.
• W2150876578 cites W1555642591 @default.
• W2150876578 cites W1556249553 @default.
• W2150876578 cites W1565534551 @default.
• W2150876578 cites W1592286181 @default.
• W2150876578 cites W1654380405 @default.
• W2150876578 cites W165624669 @default.
• W2150876578 cites W1670633125 @default.
• W2150876578 cites W1781900710 @default.
• W2150876578 cites W1876621669 @default.
• W2150876578 cites W1884398615 @default.
• W2150876578 cites W1909460102 @default.
• W2150876578 cites W1916107512 @default.
• W2150876578 cites W1961369080 @default.
• W2150876578 cites W1963482720 @default.
• W2150876578 cites W1964014092 @default.
• W2150876578 cites W1964317612 @default.
• W2150876578 cites W1965469766 @default.
• W2150876578 cites W1967734976 @default.
• W2150876578 cites W1968491716 @default.
• W2150876578 cites W1971604081 @default.
• W2150876578 cites W1974332952 @default.
• W2150876578 cites W1976458982 @default.
• W2150876578 cites W1976709166 @default.
• W2150876578 cites W1978307963 @default.
• W2150876578 cites W1978379381 @default.
• W2150876578 cites W1978767285 @default.
• W2150876578 cites W1979187915 @default.
• W2150876578 cites W1979963836 @default.
• W2150876578 cites W1980735839 @default.
• W2150876578 cites W1980787499 @default.
• W2150876578 cites W1981067823 @default.
• W2150876578 cites W1981163298 @default.
• W2150876578 cites W1981232832 @default.
• W2150876578 cites W1982214007 @default.
• W2150876578 cites W1984363963 @default.
• W2150876578 cites W1985117545 @default.
• W2150876578 cites W1988182239 @default.
• W2150876578 cites W1988519309 @default.
• W2150876578 cites W1988860179 @default.
• W2150876578 cites W1989073099 @default.
• W2150876578 cites W1989155012 @default.
• W2150876578 cites W1989289560 @default.
• W2150876578 cites W1989463851 @default.
• W2150876578 cites W1989534852 @default.
• W2150876578 cites W1989703955 @default.
• W2150876578 cites W1991497324 @default.
• W2150876578 cites W1993068187 @default.
• W2150876578 cites W1993366485 @default.
• W2150876578 cites W1994554353 @default.
• W2150876578 cites W1998776908 @default.
• W2150876578 cites W1999074163 @default.
• W2150876578 cites W1999924323 @default.
• W2150876578 cites W2000488672 @default.
• W2150876578 cites W2000544033 @default.
• W2150876578 cites W2001652592 @default.
• W2150876578 cites W2001803470 @default.
• W2150876578 cites W2002785222 @default.
• W2150876578 cites W2003213334 @default.
• W2150876578 cites W2003543462 @default.
• W2150876578 cites W2005428340 @default.
• W2150876578 cites W2006292415 @default.
• W2150876578 cites W2008582388 @default.
• W2150876578 cites W2010142606 @default.
• W2150876578 cites W2011161535 @default.
• W2150876578 cites W2014797884 @default.
• W2150876578 cites W2015042310 @default.
• W2150876578 cites W2016017780 @default.
• W2150876578 cites W2017543199 @default.
• W2150876578 cites W2018723047 @default.
• W2150876578 cites W2018907596 @default.
• W2150876578 cites W2018953051 @default.
• W2150876578 cites W2021782736 @default.
• W2150876578 cites W2023077982 @default.
• W2150876578 cites W2023235628 @default.
• W2150876578 cites W2024653583 @default.
• W2150876578 cites W2025078194 @default.
• W2150876578 cites W2025369248 @default.
• W2150876578 cites W2026704145 @default.
• W2150876578 cites W2027699595 @default.
• W2150876578 cites W2030556402 @default.
• W2150876578 cites W2030864168 @default.
• W2150876578 cites W2031268706 @default.
• W2150876578 cites W2033564637 @default.
• W2150876578 cites W2036600731 @default.
• W2150876578 cites W2037184447 @default.

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