Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150888933> ?p ?o ?g. }
- W2150888933 endingPage "32" @default.
- W2150888933 startingPage "25" @default.
- W2150888933 abstract "Abstract Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplant (AHSCT) associated with significant morbidity and mortality. This review focuses on the pathophysiology, clinical features, prevention, and treatment of acute GVHD. Specifically, we explain how new discoveries in immunology have expanded our understanding of GVHD, in which tissue damage from chemotherapy or radiation results in cytokine release, which activates T cells, resulting in proliferation and differentiation, trafficking to target organs, and tissue destruction and inflammation. Insights into the mechanisms of this disease relate directly to the development of preventive strategies and therapies, such as immunosuppression, T-cell depletion, calcineurin inhibitors, CCR5 antagonists, gut decontamination, extracorporeal photopheresis, and more. We also discuss how GVHD affects the gut, liver, and skin, as well as diagnosis, grading, and scoring. We end by examining future directions of treatment, including new immunomodulators and biomarkers. Understanding the immunobiology of GVHD and developing effective preventions and treatments are critical to the continuing success of AHSCT." @default.
- W2150888933 created "2016-06-24" @default.
- W2150888933 creator A5034651124 @default.
- W2150888933 creator A5063907259 @default.
- W2150888933 date "2012-12-19" @default.
- W2150888933 modified "2023-10-16" @default.
- W2150888933 title "Concise Review: Acute Graft-Versus-Host Disease: Immunobiology, Prevention, and Treatment" @default.
- W2150888933 cites W1521169335 @default.
- W2150888933 cites W160750031 @default.
- W2150888933 cites W1666992241 @default.
- W2150888933 cites W1795844187 @default.
- W2150888933 cites W1856214300 @default.
- W2150888933 cites W1918787965 @default.
- W2150888933 cites W1970070684 @default.
- W2150888933 cites W1971577317 @default.
- W2150888933 cites W1976063914 @default.
- W2150888933 cites W1976460197 @default.
- W2150888933 cites W1977086270 @default.
- W2150888933 cites W1988108072 @default.
- W2150888933 cites W1993229072 @default.
- W2150888933 cites W1994892164 @default.
- W2150888933 cites W1995326684 @default.
- W2150888933 cites W1995886082 @default.
- W2150888933 cites W1998955325 @default.
- W2150888933 cites W2003858484 @default.
- W2150888933 cites W2006427551 @default.
- W2150888933 cites W2010221217 @default.
- W2150888933 cites W2019057404 @default.
- W2150888933 cites W2021534575 @default.
- W2150888933 cites W2027456984 @default.
- W2150888933 cites W2027584924 @default.
- W2150888933 cites W2028455957 @default.
- W2150888933 cites W2030526926 @default.
- W2150888933 cites W2030758053 @default.
- W2150888933 cites W2033477706 @default.
- W2150888933 cites W2034952320 @default.
- W2150888933 cites W2035050419 @default.
- W2150888933 cites W2035866203 @default.
- W2150888933 cites W2037015581 @default.
- W2150888933 cites W2037119492 @default.
- W2150888933 cites W2039359386 @default.
- W2150888933 cites W2039808932 @default.
- W2150888933 cites W2044492878 @default.
- W2150888933 cites W2044560944 @default.
- W2150888933 cites W2045254759 @default.
- W2150888933 cites W2046465273 @default.
- W2150888933 cites W2052605694 @default.
- W2150888933 cites W2053278212 @default.
- W2150888933 cites W2055946087 @default.
- W2150888933 cites W2057342413 @default.
- W2150888933 cites W2058610741 @default.
- W2150888933 cites W2059608155 @default.
- W2150888933 cites W2061069485 @default.
- W2150888933 cites W2066609974 @default.
- W2150888933 cites W2067564880 @default.
- W2150888933 cites W2068021983 @default.
- W2150888933 cites W2073045132 @default.
- W2150888933 cites W2079622572 @default.
- W2150888933 cites W2087260271 @default.
- W2150888933 cites W2088905605 @default.
- W2150888933 cites W2092929403 @default.
- W2150888933 cites W2093989053 @default.
- W2150888933 cites W2094900717 @default.
- W2150888933 cites W2095284909 @default.
- W2150888933 cites W2096671282 @default.
- W2150888933 cites W2096779083 @default.
- W2150888933 cites W2097470232 @default.
- W2150888933 cites W2098131157 @default.
- W2150888933 cites W2110752492 @default.
- W2150888933 cites W2111951140 @default.
- W2150888933 cites W2117983550 @default.
- W2150888933 cites W2124165032 @default.
- W2150888933 cites W2126957024 @default.
- W2150888933 cites W2127877465 @default.
- W2150888933 cites W2130380033 @default.
- W2150888933 cites W2131161334 @default.
- W2150888933 cites W2137074910 @default.
- W2150888933 cites W2138946470 @default.
- W2150888933 cites W2139823699 @default.
- W2150888933 cites W2139891677 @default.
- W2150888933 cites W2141223501 @default.
- W2150888933 cites W2146448606 @default.
- W2150888933 cites W2146587708 @default.
- W2150888933 cites W2148755192 @default.
- W2150888933 cites W2149055573 @default.
- W2150888933 cites W2153431188 @default.
- W2150888933 cites W2157979692 @default.
- W2150888933 cites W2158370829 @default.
- W2150888933 cites W2162786037 @default.
- W2150888933 cites W2163847512 @default.
- W2150888933 cites W2164199065 @default.
- W2150888933 cites W2167372595 @default.
- W2150888933 cites W2170433336 @default.
- W2150888933 cites W2321645223 @default.
- W2150888933 cites W2330713242 @default.
- W2150888933 cites W2336061803 @default.
- W2150888933 cites W2336197601 @default.
- W2150888933 cites W4236572065 @default.