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- W2150892016 abstract "The effect of a substance present in a sample that alters the correct value of the result is referred to as analytical interference (1). Heterophilic antibodies consist of both natural antibodies and autoimmune antibodies that exhibit weak binding and polyspecificity, reacting with multiple heterogeneous antigens. Some heterophilic antibodies can react with human and animal immunoglobulins by binding to epitopes located on either the F(ab) or Fc region, although in healthy persons there is a predominance of idiotypic interactions (2).We detected what appeared to be this type of interference in a study comparing the Olympus® immunoturbidimetric assay (ITA) for ferritin on the AU-5400 automated analyzer with the Roche® electrochemiluminescence immunoassay for ferritin on the Modular E-170 analyzer. Ferritin concentrations …" @default.
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- W2150892016 date "2006-08-01" @default.
- W2150892016 modified "2023-09-25" @default.
- W2150892016 title "Interference from Heterophilic Antibodies in the Olympus Ferritin Method" @default.
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- W2150892016 doi "https://doi.org/10.1373/clinchem.2006.068486" @default.
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