FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150894805> ?p ?o ?g. }

• W2150894805 endingPage "1129" @default.
• W2150894805 startingPage "1122" @default.
• W2150894805 abstract "Abstract Motivation: A system-wide approach to revealing the underlying molecular state of a cell is a long-standing biological challenge. Developed over the last decade, gene expression profiles possess the characteristics of such an assay. They have the capacity to reveal both underlying molecular events as well as broader phenotypes such as clinical outcomes. To interpret these profiles, many gene sets have been developed that characterize biological processes. However, the full potential of these gene sets has not yet been achieved. Since the advent of gene expression databases, many have posited that they can reveal properties of activities that are not evident from individual datasets, analogous to how the expression of a single gene generally cannot reveal the activation of a biological process. Results: To address this issue, we have developed a high-throughput method to mine gene expression databases for the regulation of gene sets. Given a set of genes, we scored it against each gene expression dataset by looking for enrichment of co-regulated genes relative to an empirical null distribution. After validating the method, we applied it to address two biological problems. First, we deciphered the E2F transcriptional network. We confirmed that true transcriptional targets exhibit a distinct regulatory profile across a database. Second, we leveraged the patterns of regulation across a database of gene sets to produce an automatically generated catalog of biological processes. These demonstrations revealed the power of a global analysis of the data contained within gene expression databases, and the potential for using them to address biological questions. Contact: jeffrey.t.chang@uth.tmc.edu Supplementary information: Supplementary data are available at Bioinformatics online." @default.
• W2150894805 created "2016-06-24" @default.
• W2150894805 creator A5004242684 @default.
• W2150894805 date "2012-03-08" @default.
• W2150894805 modified "2023-09-25" @default.
• W2150894805 title "Deriving transcriptional programs and functional processes from gene expression databases" @default.
• W2150894805 cites W1517579686 @default.
• W2150894805 cites W1607267312 @default.
• W2150894805 cites W1753047181 @default.
• W2150894805 cites W1976209715 @default.
• W2150894805 cites W2010457001 @default.
• W2150894805 cites W2016311718 @default.
• W2150894805 cites W2020859582 @default.
• W2150894805 cites W2023720844 @default.
• W2150894805 cites W2043653128 @default.
• W2150894805 cites W2048066878 @default.
• W2150894805 cites W2058451329 @default.
• W2150894805 cites W2065343028 @default.
• W2150894805 cites W2068858902 @default.
• W2150894805 cites W2073727170 @default.
• W2150894805 cites W2078202582 @default.
• W2150894805 cites W2080152736 @default.
• W2150894805 cites W2080498142 @default.
• W2150894805 cites W2082668371 @default.
• W2150894805 cites W2088468751 @default.
• W2150894805 cites W2092224388 @default.
• W2150894805 cites W2094678200 @default.
• W2150894805 cites W2095718954 @default.
• W2150894805 cites W2097168572 @default.
• W2150894805 cites W2097255042 @default.
• W2150894805 cites W2099101879 @default.
• W2150894805 cites W2101155068 @default.
• W2150894805 cites W2101696428 @default.
• W2150894805 cites W2102614435 @default.
• W2150894805 cites W2103017472 @default.
• W2150894805 cites W2104357712 @default.
• W2150894805 cites W2105712639 @default.
• W2150894805 cites W2112464428 @default.
• W2150894805 cites W2114381883 @default.
• W2150894805 cites W2116961371 @default.
• W2150894805 cites W2120261416 @default.
• W2150894805 cites W2121604817 @default.
• W2150894805 cites W2123879591 @default.
• W2150894805 cites W2124711114 @default.
• W2150894805 cites W2125508747 @default.
• W2150894805 cites W2128540871 @default.
• W2150894805 cites W2129795133 @default.
• W2150894805 cites W2130410032 @default.
• W2150894805 cites W2133465414 @default.
• W2150894805 cites W2135000328 @default.
• W2150894805 cites W2135030836 @default.
• W2150894805 cites W2146264532 @default.
• W2150894805 cites W2157132621 @default.
• W2150894805 cites W2158217645 @default.
• W2150894805 cites W2160073543 @default.
• W2150894805 cites W2162874742 @default.
• W2150894805 cites W2165232124 @default.
• W2150894805 cites W2166103265 @default.
• W2150894805 cites W2168459422 @default.
• W2150894805 cites W2791873134 @default.
• W2150894805 doi "https://doi.org/10.1093/bioinformatics/bts112" @default.
• W2150894805 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3324522" @default.
• W2150894805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22408194" @default.
• W2150894805 hasPublicationYear "2012" @default.
• W2150894805 type Work @default.
• W2150894805 sameAs 2150894805 @default.
• W2150894805 citedByCount "3" @default.
• W2150894805 countsByYear W21508948052012 @default.
• W2150894805 countsByYear W21508948052015 @default.
• W2150894805 countsByYear W21508948052018 @default.
• W2150894805 crossrefType "journal-article" @default.
• W2150894805 hasAuthorship W2150894805A5004242684 @default.
• W2150894805 hasBestOaLocation W21508948051 @default.
• W2150894805 hasConcept C104317684 @default.
• W2150894805 hasConcept C150194340 @default.
• W2150894805 hasConcept C165864922 @default.
• W2150894805 hasConcept C177264268 @default.
• W2150894805 hasConcept C18431079 @default.
• W2150894805 hasConcept C199360897 @default.
• W2150894805 hasConcept C27153228 @default.
• W2150894805 hasConcept C41008148 @default.
• W2150894805 hasConcept C54355233 @default.
• W2150894805 hasConcept C67339327 @default.
• W2150894805 hasConcept C70721500 @default.
• W2150894805 hasConcept C77088390 @default.
• W2150894805 hasConcept C86803240 @default.
• W2150894805 hasConcept C90559484 @default.
• W2150894805 hasConcept C9927688 @default.
• W2150894805 hasConceptScore W2150894805C104317684 @default.
• W2150894805 hasConceptScore W2150894805C150194340 @default.
• W2150894805 hasConceptScore W2150894805C165864922 @default.
• W2150894805 hasConceptScore W2150894805C177264268 @default.
• W2150894805 hasConceptScore W2150894805C18431079 @default.
• W2150894805 hasConceptScore W2150894805C199360897 @default.
• W2150894805 hasConceptScore W2150894805C27153228 @default.
• W2150894805 hasConceptScore W2150894805C41008148 @default.
• W2150894805 hasConceptScore W2150894805C54355233 @default.
• W2150894805 hasConceptScore W2150894805C67339327 @default.

• next