Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150921727> ?p ?o ?g. }
- W2150921727 endingPage "341" @default.
- W2150921727 startingPage "324" @default.
- W2150921727 abstract "We examined the effect of restraint stress (3 hr) on plasma LH and testosterone levels, on the Leydig cell LH/hCG receptor, and on the activity of enzymes in the testicular steroidogenic pathway of the adult rat. Restraint stress caused a 47% reduction in plasma testosterone concentrations, but had no effect on plasma LH levels. The binding capacity and affinity of Leydig cell LH/hCG receptors were not affected by restraint. Stress did not affect the testicular activity of 20,22 desmolase or 3β-hydroxysteroid dehydrogenase, but testicular interstitial cells of stressed rats incubated in vitro with progesterone as a substrate produced more 17α-hydroxyprogesterone but less testosterone than control cells, and when incubated with 17α-hydroxypregnenolone, produced 39% less androstenedione and 40% less testosterone than control cells. These results suggest that restraint stress inhibited 17,20 desmolase but not 17α-hydroxylase activity. When the Δ4 pathway was blocked with cyanoketone (3β-HSD inhibitor), stress did not alter the production of pregnenolone or 17α-hydroxypregnenolone, but the production of dehydroepiandrosterone by cells from stressed rats was subnormal, suggesting again a reduction of 17,20 desmolase activity. The data suggest that a major site of the inhibitory action of restraint stress on testicular steroidogenesis is the 17,20 desmolase step. The disruption of androgen production by restraint appears to be LH independent since stress did not affect plasma LH levels, the binding capacity or affinity of LH/hCG receptors, or the activity of 20,22 desmolase." @default.
- W2150921727 created "2016-06-24" @default.
- W2150921727 creator A5006045809 @default.
- W2150921727 creator A5047961513 @default.
- W2150921727 date "1990-09-01" @default.
- W2150921727 modified "2023-09-26" @default.
- W2150921727 title "Effects of restraint stress on plasma LH and testosterone concentrations, Leydig cell LH/HCG receptors, and in vitro testicular steroidogenesis in adult rats" @default.
- W2150921727 cites W1484075233 @default.
- W2150921727 cites W1541886985 @default.
- W2150921727 cites W1544909488 @default.
- W2150921727 cites W1566852849 @default.
- W2150921727 cites W1967266232 @default.
- W2150921727 cites W1968143244 @default.
- W2150921727 cites W1986232120 @default.
- W2150921727 cites W1988617168 @default.
- W2150921727 cites W1990896009 @default.
- W2150921727 cites W1992610422 @default.
- W2150921727 cites W1996278640 @default.
- W2150921727 cites W2006294105 @default.
- W2150921727 cites W2009115016 @default.
- W2150921727 cites W2015217559 @default.
- W2150921727 cites W2020167840 @default.
- W2150921727 cites W2020931685 @default.
- W2150921727 cites W2024910805 @default.
- W2150921727 cites W2025370081 @default.
- W2150921727 cites W2026366055 @default.
- W2150921727 cites W2032997885 @default.
- W2150921727 cites W2034386154 @default.
- W2150921727 cites W2043877013 @default.
- W2150921727 cites W2050045288 @default.
- W2150921727 cites W2053898583 @default.
- W2150921727 cites W2058900555 @default.
- W2150921727 cites W2060296860 @default.
- W2150921727 cites W2064178611 @default.
- W2150921727 cites W2065948070 @default.
- W2150921727 cites W2074120083 @default.
- W2150921727 cites W2081507440 @default.
- W2150921727 cites W2084881904 @default.
- W2150921727 cites W2095393453 @default.
- W2150921727 cites W2110936392 @default.
- W2150921727 cites W2122296587 @default.
- W2150921727 cites W2125664281 @default.
- W2150921727 cites W2134406169 @default.
- W2150921727 cites W2163517010 @default.
- W2150921727 cites W2168691742 @default.
- W2150921727 cites W2185623099 @default.
- W2150921727 cites W2214407548 @default.
- W2150921727 cites W2316453664 @default.
- W2150921727 cites W2408457102 @default.
- W2150921727 cites W2504959921 @default.
- W2150921727 doi "https://doi.org/10.1016/0018-506x(90)90013-n" @default.
- W2150921727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2227847" @default.
- W2150921727 hasPublicationYear "1990" @default.
- W2150921727 type Work @default.
- W2150921727 sameAs 2150921727 @default.
- W2150921727 citedByCount "63" @default.
- W2150921727 countsByYear W21509217272013 @default.
- W2150921727 countsByYear W21509217272014 @default.
- W2150921727 countsByYear W21509217272015 @default.
- W2150921727 countsByYear W21509217272016 @default.
- W2150921727 countsByYear W21509217272017 @default.
- W2150921727 countsByYear W21509217272018 @default.
- W2150921727 countsByYear W21509217272019 @default.
- W2150921727 countsByYear W21509217272021 @default.
- W2150921727 countsByYear W21509217272022 @default.
- W2150921727 countsByYear W21509217272023 @default.
- W2150921727 crossrefType "journal-article" @default.
- W2150921727 hasAuthorship W2150921727A5006045809 @default.
- W2150921727 hasAuthorship W2150921727A5047961513 @default.
- W2150921727 hasConcept C126322002 @default.
- W2150921727 hasConcept C134018914 @default.
- W2150921727 hasConcept C170493617 @default.
- W2150921727 hasConcept C185592680 @default.
- W2150921727 hasConcept C2776683971 @default.
- W2150921727 hasConcept C2776992908 @default.
- W2150921727 hasConcept C2777736315 @default.
- W2150921727 hasConcept C2777911890 @default.
- W2150921727 hasConcept C2778575703 @default.
- W2150921727 hasConcept C2779279991 @default.
- W2150921727 hasConcept C2780193516 @default.
- W2150921727 hasConcept C2780902042 @default.
- W2150921727 hasConcept C526171541 @default.
- W2150921727 hasConcept C62231903 @default.
- W2150921727 hasConcept C71315377 @default.
- W2150921727 hasConcept C71924100 @default.
- W2150921727 hasConcept C80446465 @default.
- W2150921727 hasConcept C86803240 @default.
- W2150921727 hasConceptScore W2150921727C126322002 @default.
- W2150921727 hasConceptScore W2150921727C134018914 @default.
- W2150921727 hasConceptScore W2150921727C170493617 @default.
- W2150921727 hasConceptScore W2150921727C185592680 @default.
- W2150921727 hasConceptScore W2150921727C2776683971 @default.
- W2150921727 hasConceptScore W2150921727C2776992908 @default.
- W2150921727 hasConceptScore W2150921727C2777736315 @default.
- W2150921727 hasConceptScore W2150921727C2777911890 @default.
- W2150921727 hasConceptScore W2150921727C2778575703 @default.
- W2150921727 hasConceptScore W2150921727C2779279991 @default.
- W2150921727 hasConceptScore W2150921727C2780193516 @default.