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• W2150926544 abstract "ADP-ribosyl cyclase and/or CD38 are activated after oxytocin receptor stimulation in the hypothalamus and pituitary in adult mice, leading to facilitation of oxytocin secretion. Although cyclic adenosine 5′-diphosphoribose (cADPR) primarily acts as an intracellular second messenger, it has been suggested that extracellular cADPR stimulates intracellular ryanodine receptors after internalisation via the nucleotide-transporting capacity of CD38 in fibroblasts and astrocytes. However, little is known about whether extracellular cADPR activates neurones. To address this question, we used a model neuronal cell line, NG108-15 mouse neuroblastoma × rat glioma hybrid cells possessing CD38 but not oxytocin receptors, and measured cytosolic free calcium concentrations ([Ca2+]i). Extracellular application of cADPR to NG108-15 cells elevated [Ca2+]i at 35 °C. The elevation was significantly enhanced when measured at 40 °C. The cADPR and heat-induced [Ca2+]i increase were blocked under extracellular Ca2+-free conditions and by 2-aminoethoxydiphenyl borate, an antagonist of melastatin-related transient receptor potential channel 2 (TRPM2) cation channels. Reverse transcriptation-polymerase chain reaction analyses indicated that TRPM2 channels were expressed in NG108-15 cells. Application of oxytocin elevated [Ca2+]i in NG108-15 cells transformed to transiently express cloned human oxytocin receptors. The oxytocin-induced [Ca2+]i response was also enhanced by heat. These results indicate that the extracellular application of cADPR, together with heat, activates cation influx downstream of oxytocin receptor signalling in NG108-15 neuronal cells, and suggest the possible involvement of TRPM2 channels in oxytocin release in the mammalian brain." @default.
• W2150926544 created "2016-06-24" @default.
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• W2150926544 date "2010-05-01" @default.
• W2150926544 modified "2023-10-17" @default.
• W2150926544 title "Intracellular Calcium Elevation Induced by Extracellular Application of Cyclic-ADP-Ribose or Oxytocin is Temperature-Sensitive in Rodent NG108-15 Neuronal Cells with or without Exogenous Expression of Human Oxytocin Receptors" @default.
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• W2150926544 doi "https://doi.org/10.1111/j.1365-2826.2010.01978.x" @default.
• W2150926544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20163520" @default.
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