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- W2150944624 abstract "The permeability coefficient, Kp, of pure unbranched alkanoic acids (C2-C7) applied to isolated porcine skin, reached a maximum in the solubility parameter (δ2) range of 9.7–10 cal1/2/cm3/2. When these and other penetrants were delivered from a solvent vehicle, the following linear relationships could be demonstrated: (a) between log Kp and the molar attraction constant of the penetrant [δ2v2 or (-Ev)1/2] for six unbranched and six branched acids delivered from 1 M solution in n-heptane; (b) between Kp and the partial molal volume difference in n-heptane ( v 2 ∕ ∕ v 2 0 ) for the unbranched acids; and (c) between Kp and ( v 2 ∕ ∕ v 2 0 ) for propionic acid delivered from 1 M solutions in nine solvents having δ1 values in the range 7.4–12.7 cal1/2/cm3/2. Drug penetrability in a given series could be assessed from knowledge of the excess free energy of the penetrant in the delivery system used." @default.
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- W2150944624 date "1984-04-01" @default.
- W2150944624 modified "2023-10-13" @default.
- W2150944624 title "Percutaneous Absorption of Alkanoic Acids 11: Application of Regular Solution Theory" @default.
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- W2150944624 doi "https://doi.org/10.1002/jps.2600730426" @default.
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