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• W2150990390 abstract "<h3>Objectives</h3> CT colonography (CTC) may be an acceptable test for colorectal cancer screening but bowel preparation can be a barrier to uptake. This study tested the hypothesis that prospective screening invitees would prefer full-laxative preparation with higher sensitivity and specificity for polyps, despite greater burden, over less burdensome reduced-laxative or non-laxative alternatives with lower sensitivity and specificity. <h3>Design</h3> Discrete choice experiment. <h3>Setting</h3> Online, web-based survey. <h3>Participants</h3> 2819 adults (45–54 years) from the UK responded to an online invitation to take part in a cancer screening study. Quota sampling ensured that the sample reflected key demographics of the target population and had no relevant bowel disease or medical qualifications. The analysis comprised 607 participants. <h3>Interventions</h3> After receiving information about screening and CTC, participants completed 3–4 choice scenarios. Scenarios showed two hypothetical forms of CTC with different permutations of three attributes: preparation, sensitivity and specificity for polyps. <h3>Primary outcome measures</h3> Participants considered the trade-offs in each scenario and stated their preferred test (or chose neither). <h3>Results</h3> Preparation and sensitivity for polyps were both significant predictors of preferences (coefficients: −3.834 to −6.346 for preparation, 0.207–0.257 for sensitivity; p<0.0005). These attributes predicted preferences to a similar extent. Realistic specificity values were non-significant (−0.002 to 0.025; p=0.953). Contrary to our hypothesis, probabilities of selecting tests were similar for realistic forms of full-laxative, reduced-laxative and non-laxative preparations (0.362–0.421). However, they were substantially higher for hypothetical improved forms of reduced-laxative or non-laxative preparations with better sensitivity for polyps (0.584–0.837). <h3>Conclusions</h3> Uptake of CTC following non-laxative or reduced-laxative preparations is unlikely to be greater than following full-laxative preparation as perceived gains from reduced burden may be diminished by reduced sensitivity. However, both attributes are important so a more sensitive form of reduced-laxative or non-laxative preparation might improve uptake substantially." @default.
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• W2150990390 date "2014-04-01" @default.
• W2150990390 modified "2023-09-26" @default.
• W2150990390 title "Quantifying public preferences for different bowel preparation options prior to screening CT colonography: a discrete choice experiment" @default.
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• W2150990390 doi "https://doi.org/10.1136/bmjopen-2013-004327" @default.
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