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• W2151018542 endingPage "496" @default.
• W2151018542 startingPage "472" @default.
• W2151018542 abstract "Background: Given the long-term morbidity of juvenile-onset major depressive disorder (MDD), it is timely to consider whether more effort should be dedicated to its primary and secondary prevention. Methods: We reviewed studies of prodromal symptoms that may herald a first episode pediatric MDD and considered whether that literature has made an impact on secondary prevention (efforts to prevent progression from symptoms to full disorder). We also reviewed studies of children at familial risk for MDD that addressed atypical affectivity and the regulation of sad, dysphoric affect (mood repair) and related physiological systems, and considered whether research in those areas has made an impact on primary prevention of pediatric MDD (efforts to prevent the disorder). Results: A compelling body of literature indicates that depressive symptoms in youngsters predict subsequent MDD across the juvenile (and early adult) years and that any combination of several symptoms for at least one week is informative in that regard. These findings are echoed in the case selection criteria used by many secondary prevention programs. Convergent findings also indicate that (compared to typical peers) young offspring at familial risk for depression manifest low positive affectivity and compromised mood repair, along with signs of dysfunction in three intertwined physiological systems that contribute to affectivity and mood repair (the hypothalamic–pituitary–adrenal (HPA) axis, cerebral hemispheric asymmetry, and cardiac vagal control). While all these affect-related parameters are suitable for case selection and as intervention targets, they have not yet made an impact on primary prevention programs. Conclusions: According to recent meta-analyses, attempts to prevent pediatric depression have not lived up to expectations. Based on our review, possible reasons for this include: (a) the use of case selection criteria that yield samples heterogeneous with regard to whether the symptoms are truly prodromal to an episode of MDD or are trait-like (which could affect response to the intervention), (b) failure to fully capitalize on the broad-ranging literature on vulnerability to pediatric MDD, as evidenced by the infrequent use of family history of depression (a robust index of vulnerability) or combined indices of vulnerability for case selection, and (c) lack of synchrony between dimensions of vulnerability and the content of the prevention program, as indicated by the overwhelming use of cognitive-behavioral interventions, irrespective of subjects’ age, developmental readiness, and whether or not they evidenced the relevant cognitive vulnerability. Prevention trials of pediatric MDD could benefit from new approaches to case selection that combine various indices of vulnerability, more effective use of existing findings, and new or modified interventions that are developmentally sensitive." @default.
• W2151018542 created "2016-06-24" @default.
• W2151018542 creator A5037223745 @default.
• W2151018542 creator A5077048656 @default.
• W2151018542 date "2010-02-22" @default.
• W2151018542 modified "2023-09-25" @default.
• W2151018542 title "Prodromal symptoms and atypical affectivity as predictors of major depression in juveniles: implications for prevention" @default.
• W2151018542 cites W1215075678 @default.
• W2151018542 cites W130487737 @default.
• W2151018542 cites W13950139 @default.
• W2151018542 cites W151898865 @default.
• W2151018542 cites W1519039631 @default.
• W2151018542 cites W1535336772 @default.
• W2151018542 cites W1724411085 @default.
• W2151018542 cites W1956573559 @default.
• W2151018542 cites W1963642452 @default.
• W2151018542 cites W1963704462 @default.
• W2151018542 cites W1965161398 @default.
• W2151018542 cites W1966905618 @default.
• W2151018542 cites W1969170406 @default.
• W2151018542 cites W1969990835 @default.
• W2151018542 cites W1971260014 @default.
• W2151018542 cites W1971467163 @default.
• W2151018542 cites W1971481509 @default.
• W2151018542 cites W1973606585 @default.
• W2151018542 cites W1974681461 @default.
• W2151018542 cites W1974802010 @default.
• W2151018542 cites W1975449695 @default.
• W2151018542 cites W1981250831 @default.
• W2151018542 cites W1982619374 @default.
• W2151018542 cites W1985266582 @default.
• W2151018542 cites W1985859448 @default.
• W2151018542 cites W1986467210 @default.
• W2151018542 cites W1987109476 @default.
• W2151018542 cites W1988981053 @default.
• W2151018542 cites W1989819327 @default.
• W2151018542 cites W1991093386 @default.
• W2151018542 cites W1991547820 @default.
• W2151018542 cites W1991703513 @default.
• W2151018542 cites W1994342224 @default.
• W2151018542 cites W1994769532 @default.
• W2151018542 cites W1995329201 @default.
• W2151018542 cites W1996873157 @default.
• W2151018542 cites W1997214473 @default.
• W2151018542 cites W1997594680 @default.
• W2151018542 cites W1997669140 @default.
• W2151018542 cites W1998279803 @default.
• W2151018542 cites W2000308176 @default.
• W2151018542 cites W2001179208 @default.
• W2151018542 cites W2002468035 @default.
• W2151018542 cites W200251779 @default.
• W2151018542 cites W2002741313 @default.
• W2151018542 cites W2004940211 @default.
• W2151018542 cites W2006121037 @default.
• W2151018542 cites W2009685367 @default.
• W2151018542 cites W2012890086 @default.
• W2151018542 cites W2013491940 @default.
• W2151018542 cites W2015552643 @default.
• W2151018542 cites W2016489978 @default.
• W2151018542 cites W2018445256 @default.
• W2151018542 cites W2018518524 @default.
• W2151018542 cites W2020292986 @default.
• W2151018542 cites W2020486864 @default.
• W2151018542 cites W2021042367 @default.
• W2151018542 cites W2024059773 @default.
• W2151018542 cites W2025751302 @default.
• W2151018542 cites W2027359374 @default.
• W2151018542 cites W2028980996 @default.
• W2151018542 cites W2030000401 @default.
• W2151018542 cites W2030272615 @default.
• W2151018542 cites W2030343696 @default.
• W2151018542 cites W2032875853 @default.
• W2151018542 cites W2033787268 @default.
• W2151018542 cites W2038052815 @default.
• W2151018542 cites W2038076953 @default.
• W2151018542 cites W2039361616 @default.
• W2151018542 cites W2039434262 @default.
• W2151018542 cites W2040053981 @default.
• W2151018542 cites W2040358455 @default.
• W2151018542 cites W2041832614 @default.
• W2151018542 cites W2042168008 @default.
• W2151018542 cites W2043357964 @default.
• W2151018542 cites W2043519044 @default.
• W2151018542 cites W2043872160 @default.
• W2151018542 cites W2043951293 @default.
• W2151018542 cites W2044523195 @default.
• W2151018542 cites W2045107909 @default.
• W2151018542 cites W2045914666 @default.
• W2151018542 cites W2046469052 @default.
• W2151018542 cites W2046927154 @default.
• W2151018542 cites W2046960533 @default.
• W2151018542 cites W2048287365 @default.
• W2151018542 cites W2049264787 @default.
• W2151018542 cites W2051181638 @default.
• W2151018542 cites W2052424967 @default.
• W2151018542 cites W2054762456 @default.
• W2151018542 cites W2056565869 @default.
• W2151018542 cites W2058331473 @default.

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