FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2151034204> ?p ?o ?g. }

• W2151034204 endingPage "83" @default.
• W2151034204 startingPage "80" @default.
• W2151034204 abstract "While 25-OH-D3 serum levels in humans undergo a large seasonal variation, 1,25-(OH)2-D3 is regulated within a narrow range. We speculate that in addition to the known genomic and nongenomic regulation there could be further epigenetic mechanisms involved. We annotated the human CYP27B1 (α-1-hydroxylase) and CYP24A1 (24-hydroxylase) genes for CpG islands and sequenced these in bisulfite treated DNA extracted of peripheral blood lymphocytes from 384 individuals. 40 CpG sites could be analyzed, of these 15 in CYP27B1 and 25 in CYP24A1. The average methylation ratio (MR) in CYP27B1 was 11% (s.d. 5%) with the highest ratio observed in exon 1 (38%). CYP24A1 showed only a 6.5% MR (s.d. 5%). Neither CYP24A1 nor CYP27B1 MR correlated with season of examination date nor with current 25-OH-D3 and 1,25-(OH)2-D3 serum levels except of a weak association of three consecutive CYP27B1 CpG sites and 25-OH-D3 levels. In summary, human PBLs showed only weak methylation in the upstream region of CYP27B1 and none in CYP24A1. As PBLs represent an heterogeneous pool of cells, a further analysis of the seasonal methylation pattern in B or T cell subsets (or other tissues like liver or kidney) is warranted including an extended coverage of the CYP27B1 promotor." @default.
• W2151034204 created "2016-06-24" @default.
• W2151034204 creator A5005730644 @default.
• W2151034204 creator A5040733459 @default.
• W2151034204 creator A5066069656 @default.
• W2151034204 creator A5077573086 @default.
• W2151034204 date "2010-07-01" @default.
• W2151034204 modified "2023-09-29" @default.
• W2151034204 title "Epigenetic regulation of vitamin D converting enzymes" @default.
• W2151034204 cites W1983283608 @default.
• W2151034204 cites W1991003437 @default.
• W2151034204 cites W2020403353 @default.
• W2151034204 cites W2022808915 @default.
• W2151034204 cites W2026231412 @default.
• W2151034204 cites W2046423800 @default.
• W2151034204 cites W2055393561 @default.
• W2151034204 cites W2068299803 @default.
• W2151034204 cites W2069550466 @default.
• W2151034204 cites W2080642632 @default.
• W2151034204 cites W2086120628 @default.
• W2151034204 cites W2113869887 @default.
• W2151034204 cites W2114301704 @default.
• W2151034204 cites W2116660030 @default.
• W2151034204 cites W2145669281 @default.
• W2151034204 cites W2147339766 @default.
• W2151034204 doi "https://doi.org/10.1016/j.jsbmb.2010.03.056" @default.
• W2151034204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20304056" @default.
• W2151034204 hasPublicationYear "2010" @default.
• W2151034204 type Work @default.
• W2151034204 sameAs 2151034204 @default.
• W2151034204 citedByCount "21" @default.
• W2151034204 countsByYear W21510342042013 @default.
• W2151034204 countsByYear W21510342042014 @default.
• W2151034204 countsByYear W21510342042015 @default.
• W2151034204 countsByYear W21510342042016 @default.
• W2151034204 countsByYear W21510342042017 @default.
• W2151034204 countsByYear W21510342042018 @default.
• W2151034204 countsByYear W21510342042019 @default.
• W2151034204 countsByYear W21510342042020 @default.
• W2151034204 countsByYear W21510342042022 @default.
• W2151034204 countsByYear W21510342042023 @default.
• W2151034204 crossrefType "journal-article" @default.
• W2151034204 hasAuthorship W2151034204A5005730644 @default.
• W2151034204 hasAuthorship W2151034204A5040733459 @default.
• W2151034204 hasAuthorship W2151034204A5066069656 @default.
• W2151034204 hasAuthorship W2151034204A5077573086 @default.
• W2151034204 hasConcept C101762097 @default.
• W2151034204 hasConcept C104317684 @default.
• W2151034204 hasConcept C121912465 @default.
• W2151034204 hasConcept C124490489 @default.
• W2151034204 hasConcept C126322002 @default.
• W2151034204 hasConcept C134018914 @default.
• W2151034204 hasConcept C140173407 @default.
• W2151034204 hasConcept C150194340 @default.
• W2151034204 hasConcept C153911025 @default.
• W2151034204 hasConcept C179639408 @default.
• W2151034204 hasConcept C189235521 @default.
• W2151034204 hasConcept C190727270 @default.
• W2151034204 hasConcept C33288867 @default.
• W2151034204 hasConcept C41091548 @default.
• W2151034204 hasConcept C54355233 @default.
• W2151034204 hasConcept C71924100 @default.
• W2151034204 hasConcept C76743606 @default.
• W2151034204 hasConcept C86803240 @default.
• W2151034204 hasConceptScore W2151034204C101762097 @default.
• W2151034204 hasConceptScore W2151034204C104317684 @default.
• W2151034204 hasConceptScore W2151034204C121912465 @default.
• W2151034204 hasConceptScore W2151034204C124490489 @default.
• W2151034204 hasConceptScore W2151034204C126322002 @default.
• W2151034204 hasConceptScore W2151034204C134018914 @default.
• W2151034204 hasConceptScore W2151034204C140173407 @default.
• W2151034204 hasConceptScore W2151034204C150194340 @default.
• W2151034204 hasConceptScore W2151034204C153911025 @default.
• W2151034204 hasConceptScore W2151034204C179639408 @default.
• W2151034204 hasConceptScore W2151034204C189235521 @default.
• W2151034204 hasConceptScore W2151034204C190727270 @default.
• W2151034204 hasConceptScore W2151034204C33288867 @default.
• W2151034204 hasConceptScore W2151034204C41091548 @default.
• W2151034204 hasConceptScore W2151034204C54355233 @default.
• W2151034204 hasConceptScore W2151034204C71924100 @default.
• W2151034204 hasConceptScore W2151034204C76743606 @default.
• W2151034204 hasConceptScore W2151034204C86803240 @default.
• W2151034204 hasIssue "1-2" @default.
• W2151034204 hasLocation W21510342041 @default.
• W2151034204 hasLocation W21510342042 @default.
• W2151034204 hasOpenAccess W2151034204 @default.
• W2151034204 hasPrimaryLocation W21510342041 @default.
• W2151034204 hasRelatedWork W1965970372 @default.
• W2151034204 hasRelatedWork W2004417708 @default.
• W2151034204 hasRelatedWork W2041013779 @default.
• W2151034204 hasRelatedWork W2151034204 @default.
• W2151034204 hasRelatedWork W2570149195 @default.
• W2151034204 hasRelatedWork W2888757180 @default.
• W2151034204 hasRelatedWork W2909484358 @default.
• W2151034204 hasRelatedWork W3186871407 @default.
• W2151034204 hasRelatedWork W3216760469 @default.
• W2151034204 hasRelatedWork W4205403772 @default.
• W2151034204 hasVolume "121" @default.

• next