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- W2151034732 endingPage "1664" @default.
- W2151034732 startingPage "1654" @default.
- W2151034732 abstract "Canonical β-catenin-mediated Wnt signaling is essential for the induction of nephron development. Noncanonical Wnt/planar cell polarity (PCP) pathways contribute to processes such as cell polarization and cytoskeletal modulation in several tissues. Although PCP components likely establish the plane of polarization in kidney tubulogenesis, whether PCP effectors directly modulate the actin cytoskeleton in tubulogenesis is unknown. Here, we investigated the roles of Wnt PCP components in cytoskeletal assembly during kidney tubule morphogenesis in Xenopus laevis and zebrafish. We found that during tubulogenesis, the developing pronephric anlagen expresses Daam1 and its interacting Rho-GEF (WGEF), which compose one PCP/noncanonical Wnt pathway branch. Knockdown of Daam1 resulted in reduced expression of late pronephric epithelial markers with no apparent effect upon early markers of patterning and determination. Inhibiting various points in the Daam1 signaling pathway significantly reduced pronephric tubulogenesis. These data indicate that pronephric tubulogenesis requires the Daam1/WGEF/Rho PCP pathway." @default.
- W2151034732 created "2016-06-24" @default.
- W2151034732 creator A5018951212 @default.
- W2151034732 creator A5039586437 @default.
- W2151034732 creator A5041654210 @default.
- W2151034732 creator A5046623358 @default.
- W2151034732 creator A5046881682 @default.
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- W2151034732 creator A5080177727 @default.
- W2151034732 creator A5083336874 @default.
- W2151034732 creator A5086767249 @default.
- W2151034732 date "2011-09-01" @default.
- W2151034732 modified "2023-10-14" @default.
- W2151034732 title "Pronephric Tubulogenesis Requires Daam1-Mediated Planar Cell Polarity Signaling" @default.
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