FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2151041131> ?p ?o ?g. }

• W2151041131 endingPage "2798" @default.
• W2151041131 startingPage "2790" @default.
• W2151041131 abstract "Asthma and chronic obstructive pulmonary disease (COPD) are associated with Th2 and Th1 differentiated T cells. The cytokine thymic stromal lymphopoietin (TSLP) promotes differentiation of Th2 T cells and secretion of chemokines which preferentially attract them. We hypothesized that there is distinct airways expression of TSLP and chemokines which preferentially attract Th1- and Th2-type T cells, and influx of T cells bearing their receptors in asthma and COPD. In situ hybridization, immunohistochemistry, and ELISA were used to examine the expression and cellular provenance of TSLP, Th2-attracting (TARC/CCL17, MDC/CCL22, I-309/CCL1), and Th1-attracting (IP-10/CXCL10, I-TAC/CXCL11) chemokines in the bronchial mucosa and bronchoalveolar lavage fluid of subjects with moderate/severe asthma, COPD, and controls. Cells expressing mRNA encoding TSLP, TARC/CCL17, MDC/CCL22, and IP-10/CXCL10, but not I-TAC/CXCL11 and I-309/CCL1, were significantly increased in severe asthma and COPD as compared with non-smoker controls (p < 0.02). This pattern was reflected in bronchoalveolar lavage fluid protein concentrations. Expression of the same chemokines was also increased in ex- and current smokers. The cellular sources of TSLP and chemokines were strikingly similar in severe asthma and COPD. The numbers of total bronchial mucosal T cells expressing the chemokine receptors CCR4, CCR8, and CXCR3 did not significantly differ in asthma, COPD, and controls. Both asthma and COPD are associated with elevated bronchial mucosal expression of TSLP and the same Th1- and Th2-attracting chemokines. Increased expression of these chemokines is not, however, associated with selective accumulation of T cells bearing their receptors." @default.
• W2151041131 created "2016-06-24" @default.
• W2151041131 creator A5000032555 @default.
• W2151041131 creator A5008486711 @default.
• W2151041131 creator A5013082890 @default.
• W2151041131 creator A5015693854 @default.
• W2151041131 creator A5016507578 @default.
• W2151041131 creator A5043703051 @default.
• W2151041131 creator A5043708055 @default.
• W2151041131 creator A5046811254 @default.
• W2151041131 creator A5050523657 @default.
• W2151041131 creator A5055603180 @default.
• W2151041131 creator A5071677960 @default.
• W2151041131 creator A5072673731 @default.
• W2151041131 creator A5089384499 @default.
• W2151041131 date "2008-08-06" @default.
• W2151041131 modified "2023-10-14" @default.
• W2151041131 title "Expression and Cellular Provenance of Thymic Stromal Lymphopoietin and Chemokines in Patients with Severe Asthma and Chronic Obstructive Pulmonary Disease" @default.
• W2151041131 cites W1545953801 @default.
• W2151041131 cites W1625157530 @default.
• W2151041131 cites W1822726093 @default.
• W2151041131 cites W1912933271 @default.
• W2151041131 cites W1951453186 @default.
• W2151041131 cites W1955383587 @default.
• W2151041131 cites W1985264526 @default.
• W2151041131 cites W1991656827 @default.
• W2151041131 cites W1997711968 @default.
• W2151041131 cites W1999964657 @default.
• W2151041131 cites W2002245140 @default.
• W2151041131 cites W2006620904 @default.
• W2151041131 cites W2015784582 @default.
• W2151041131 cites W2023010212 @default.
• W2151041131 cites W2026755999 @default.
• W2151041131 cites W2035722718 @default.
• W2151041131 cites W2038489376 @default.
• W2151041131 cites W2041314309 @default.
• W2151041131 cites W2043614069 @default.
• W2151041131 cites W2045616259 @default.
• W2151041131 cites W2046747192 @default.
• W2151041131 cites W2048899539 @default.
• W2151041131 cites W2082276691 @default.
• W2151041131 cites W2082993687 @default.
• W2151041131 cites W2095955239 @default.
• W2151041131 cites W2098333708 @default.
• W2151041131 cites W2101436464 @default.
• W2151041131 cites W2111465284 @default.
• W2151041131 cites W2112666289 @default.
• W2151041131 cites W2114770406 @default.
• W2151041131 cites W2126475210 @default.
• W2151041131 cites W2129555736 @default.
• W2151041131 cites W2133763277 @default.
• W2151041131 cites W2135790224 @default.
• W2151041131 cites W2142566654 @default.
• W2151041131 cites W2147064547 @default.
• W2151041131 cites W2160129587 @default.
• W2151041131 cites W2161167143 @default.
• W2151041131 cites W2163984817 @default.
• W2151041131 cites W2164739672 @default.
• W2151041131 cites W2170948066 @default.
• W2151041131 cites W2171522479 @default.
• W2151041131 doi "https://doi.org/10.4049/jimmunol.181.4.2790" @default.
• W2151041131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18684970" @default.
• W2151041131 hasPublicationYear "2008" @default.
• W2151041131 type Work @default.
• W2151041131 sameAs 2151041131 @default.
• W2151041131 citedByCount "336" @default.
• W2151041131 countsByYear W21510411312012 @default.
• W2151041131 countsByYear W21510411312013 @default.
• W2151041131 countsByYear W21510411312014 @default.
• W2151041131 countsByYear W21510411312015 @default.
• W2151041131 countsByYear W21510411312016 @default.
• W2151041131 countsByYear W21510411312017 @default.
• W2151041131 countsByYear W21510411312018 @default.
• W2151041131 countsByYear W21510411312019 @default.
• W2151041131 countsByYear W21510411312020 @default.
• W2151041131 countsByYear W21510411312021 @default.
• W2151041131 countsByYear W21510411312022 @default.
• W2151041131 countsByYear W21510411312023 @default.
• W2151041131 crossrefType "journal-article" @default.
• W2151041131 hasAuthorship W2151041131A5000032555 @default.
• W2151041131 hasAuthorship W2151041131A5008486711 @default.
• W2151041131 hasAuthorship W2151041131A5013082890 @default.
• W2151041131 hasAuthorship W2151041131A5015693854 @default.
• W2151041131 hasAuthorship W2151041131A5016507578 @default.
• W2151041131 hasAuthorship W2151041131A5043703051 @default.
• W2151041131 hasAuthorship W2151041131A5043708055 @default.
• W2151041131 hasAuthorship W2151041131A5046811254 @default.
• W2151041131 hasAuthorship W2151041131A5050523657 @default.
• W2151041131 hasAuthorship W2151041131A5055603180 @default.
• W2151041131 hasAuthorship W2151041131A5071677960 @default.
• W2151041131 hasAuthorship W2151041131A5072673731 @default.
• W2151041131 hasAuthorship W2151041131A5089384499 @default.
• W2151041131 hasBestOaLocation W21510411311 @default.
• W2151041131 hasConcept C126322002 @default.
• W2151041131 hasConcept C12823836 @default.
• W2151041131 hasConcept C13373296 @default.
• W2151041131 hasConcept C13425408 @default.
• W2151041131 hasConcept C134678942 @default.

• next