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- W21510457 abstract "For many years, the impact of ionizing radiation on cell biology and survival was not fully understood, and thought to be solely dependent on the levels of DNA damage caused following radiation exposure. Similarly, the mechanisms by which growth factors and cytokines modulate cell behavior were largely unknown. In the mid-1980s, with the discovery of the first mitogen-activated protein kinase (MAPK) pathway and with subsequent discoveries of other MAPK family pathways in the early 1990s, our understanding of the hormonal control of cell biology was provided with a greater degree of molecular underpinning. In light of these findings, the ability of ionizing radiation to control the activity of MAPK family (and other) signaling pathways was first investigated in the mid-1990s. It was discovered that ionizing radiation in a cell type-dependent manner simultaneously activates multiple intracellular signal transduction pathways: the activation of some pathways has been reported to be DNAdamage dependent, that of others by generation of lipids such as ceramide, whereas others have been noted to be dependent on mitochondria-derived reactive oxygen/ nitrogen species and the activation of growth factor receptor tyrosine kinases. The precise roles of growth factor receptors and signal transduction pathways in cellular responses to radiation exposure are presently under intense investigation." @default.
- W21510457 created "2016-06-24" @default.
- W21510457 creator A5061036144 @default.
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- W21510457 creator A5069980003 @default.
- W21510457 creator A5085316261 @default.
- W21510457 date "2007-11-08" @default.
- W21510457 modified "2023-09-26" @default.
- W21510457 title "Response and Resistance to Ionizing Radiation" @default.
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