FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2151050872> ?p ?o ?g. }

• W2151050872 endingPage "854" @default.
• W2151050872 startingPage "848" @default.
• W2151050872 abstract "Abstract Objectives The aim of this study was to determine the factor changing the hepatic disposition of a drug during hypothermia using a rat liver perfusion system. Methods The livers of male Wistar rats were perfused at 37, 32 or 28°C in the single-pass mode. Venous outflow dilution patterns and biliary excretion rate patterns of phenolsulfonphthalein (PSP), indocyanine green (ICG) and fluorescein isothiocyanate (FITC)-dextran (FD-4, MW 4400) after the injection of a bolus into the perfused rat liver were analysed based on statistical moment theory. Key findings The first-pass extraction ratio (Eh) of PSP was significantly decreased at 32 and 28°C compared with 37°C. The biliary recovery of PSP and its conjugate was decreased and the biliary excretion was kept at a high concentration and was prolonged by low perfusion temperatures. ICG was almost extracted by a single-pass through the liver even at 32 and 28°C. The biliary recovery of ICG was significantly decreased at low temperature. Although the distribution volume of FD-4 as a vascular reference was not changed by perfusion temperature, the Eh of FD-4 was decreased at 28°C although not markedly. Conclusion The change in hepatic disposition of a drug at low perfusion temperatures differed according to disposition processes under hypothermia." @default.
• W2151050872 created "2016-06-24" @default.
• W2151050872 creator A5008993395 @default.
• W2151050872 creator A5020764710 @default.
• W2151050872 creator A5024057178 @default.
• W2151050872 creator A5026087172 @default.
• W2151050872 creator A5033101233 @default.
• W2151050872 creator A5041954417 @default.
• W2151050872 creator A5058359692 @default.
• W2151050872 creator A5061258543 @default.
• W2151050872 creator A5079846226 @default.
• W2151050872 date "2012-02-21" @default.
• W2151050872 modified "2023-09-26" @default.
• W2151050872 title "Evaluation of changes in hepatic disposition of phenolsulfonphthalein, indocyanine green and fluorescein isothiocyanate-dextran at low temperatures using a rat liver perfusion system†" @default.
• W2151050872 cites W182382073 @default.
• W2151050872 cites W1972367009 @default.
• W2151050872 cites W1990761883 @default.
• W2151050872 cites W2006979467 @default.
• W2151050872 cites W2027294194 @default.
• W2151050872 cites W2050648840 @default.
• W2151050872 cites W2058006048 @default.
• W2151050872 cites W2059545303 @default.
• W2151050872 cites W2071200481 @default.
• W2151050872 cites W2081504350 @default.
• W2151050872 cites W2094469434 @default.
• W2151050872 cites W2129028425 @default.
• W2151050872 cites W2166103891 @default.
• W2151050872 cites W2317227650 @default.
• W2151050872 cites W2324931970 @default.
• W2151050872 cites W2327295093 @default.
• W2151050872 cites W2405982167 @default.
• W2151050872 doi "https://doi.org/10.1111/j.2042-7158.2012.01478.x" @default.
• W2151050872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22571263" @default.
• W2151050872 hasPublicationYear "2012" @default.
• W2151050872 type Work @default.
• W2151050872 sameAs 2151050872 @default.
• W2151050872 citedByCount "4" @default.
• W2151050872 countsByYear W21510508722013 @default.
• W2151050872 countsByYear W21510508722016 @default.
• W2151050872 countsByYear W21510508722019 @default.
• W2151050872 countsByYear W21510508722020 @default.
• W2151050872 crossrefType "journal-article" @default.
• W2151050872 hasAuthorship W2151050872A5008993395 @default.
• W2151050872 hasAuthorship W2151050872A5020764710 @default.
• W2151050872 hasAuthorship W2151050872A5024057178 @default.
• W2151050872 hasAuthorship W2151050872A5026087172 @default.
• W2151050872 hasAuthorship W2151050872A5033101233 @default.
• W2151050872 hasAuthorship W2151050872A5041954417 @default.
• W2151050872 hasAuthorship W2151050872A5058359692 @default.
• W2151050872 hasAuthorship W2151050872A5061258543 @default.
• W2151050872 hasAuthorship W2151050872A5079846226 @default.
• W2151050872 hasBestOaLocation W21510508721 @default.
• W2151050872 hasConcept C10146269 @default.
• W2151050872 hasConcept C121332964 @default.
• W2151050872 hasConcept C126322002 @default.
• W2151050872 hasConcept C142724271 @default.
• W2151050872 hasConcept C146957229 @default.
• W2151050872 hasConcept C185592680 @default.
• W2151050872 hasConcept C2777019933 @default.
• W2151050872 hasConcept C2777339698 @default.
• W2151050872 hasConcept C2777390192 @default.
• W2151050872 hasConcept C2778015030 @default.
• W2151050872 hasConcept C2781065829 @default.
• W2151050872 hasConcept C43376680 @default.
• W2151050872 hasConcept C43617362 @default.
• W2151050872 hasConcept C55493867 @default.
• W2151050872 hasConcept C62520636 @default.
• W2151050872 hasConcept C71924100 @default.
• W2151050872 hasConcept C91881484 @default.
• W2151050872 hasConceptScore W2151050872C10146269 @default.
• W2151050872 hasConceptScore W2151050872C121332964 @default.
• W2151050872 hasConceptScore W2151050872C126322002 @default.
• W2151050872 hasConceptScore W2151050872C142724271 @default.
• W2151050872 hasConceptScore W2151050872C146957229 @default.
• W2151050872 hasConceptScore W2151050872C185592680 @default.
• W2151050872 hasConceptScore W2151050872C2777019933 @default.
• W2151050872 hasConceptScore W2151050872C2777339698 @default.
• W2151050872 hasConceptScore W2151050872C2777390192 @default.
• W2151050872 hasConceptScore W2151050872C2778015030 @default.
• W2151050872 hasConceptScore W2151050872C2781065829 @default.
• W2151050872 hasConceptScore W2151050872C43376680 @default.
• W2151050872 hasConceptScore W2151050872C43617362 @default.
• W2151050872 hasConceptScore W2151050872C55493867 @default.
• W2151050872 hasConceptScore W2151050872C62520636 @default.
• W2151050872 hasConceptScore W2151050872C71924100 @default.
• W2151050872 hasConceptScore W2151050872C91881484 @default.
• W2151050872 hasIssue "6" @default.
• W2151050872 hasLocation W21510508721 @default.
• W2151050872 hasLocation W21510508722 @default.
• W2151050872 hasLocation W21510508723 @default.
• W2151050872 hasOpenAccess W2151050872 @default.
• W2151050872 hasPrimaryLocation W21510508721 @default.
• W2151050872 hasRelatedWork W1884098138 @default.
• W2151050872 hasRelatedWork W1964819234 @default.
• W2151050872 hasRelatedWork W1967479826 @default.
• W2151050872 hasRelatedWork W1975243918 @default.
• W2151050872 hasRelatedWork W1998987725 @default.
• W2151050872 hasRelatedWork W2001008105 @default.

• next