FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2151051731> ?p ?o ?g. }

• W2151051731 endingPage "1176" @default.
• W2151051731 startingPage "1167" @default.
• W2151051731 abstract "Intracoronary infusions of acetylcholine (ACh) and the nitric oxide synthase (NOS) inhibitor N(G)-monomethyl-l-arginine (l-NMMA) are routinely used to assess endothelial function in the human coronary circulation. Currently, there are no studies that examine whether the response to one of these agents predicts the response to the other in a given individual. We sought to determine whether human coronary vasomotor responses to intracoronary ACh are predictive of the response to intracoronary l-NMMA. Following diagnostic coronary angiography, a coronary sinus catheter was placed. Sequential intracoronary infusions of ACh and l-NMMA were performed in 14 patients without severe coronary artery disease (CAD). In nine patients with severe CAD, only l-NMMA was infused. Quantitative coronary angiography was performed immediately following infusions to determine changes in coronary diameter. Coronary sinus oxygen saturation and the transcardiac oxygen saturation gradients were determined during infusions as an index of coronary blood flow (CBF). There were no significant differences in the prevalence of hypertension, diabetes, smoking or plasma creatinine or cholesterol levels between patients with and without severe CAD. In the 14 patients without severe CAD, ACh reduced coronary diameter on average by 8% (from 2.7 ± 0.8 to 2.5 ± 0.8 mm, P = 0.003) and reduced the transcardiac oxygen saturation gradient from 63 ± 8 to 42 ± 16% (P = 0.0001). N(G)-Monomethyl-l-arginine had no significant effect on coronary diameter (from 2.7 ± 0.8 to 2.7 ± 0.8 mm, n.s.) and did not alter the transcardiac oxygen saturation gradient (from 63 ± 8 to 63 ± 7%, n.s.). A positive rather than negative correlation was observed between the ACh- and l-NMMA-induced changes in coronary diameter (r = 0.752, P = 0.0002). In nine patients with severe CAD who did not receive ACh, l-NMMA had no effect on coronary diameter but produced an increased transcardiac oxygen saturation gradient consistent with reduced CBF (from 58 ± 5 to 62 ± 4%, P = 0.003). The CBF response to l-NMMA was significantly different between the two groups (P = 0.002). The failure of l-NMMA to reduce CBF following ACh infusion, in contrast to the results seen in the l-NMMA-only group, suggests that NOS had been rendered dysfunctional by the ACh infusion itself. The positive correlation in changes to coronary diameter between ACh and l-NMMA suggests that the degree of NOS dysfunction was directly correlated to the degree of preceding activation by ACh. Combined, these unexpected results suggest that ACh administration may acutely modify the function of NOS in the human coronary circulation." @default.
• W2151051731 created "2016-06-24" @default.
• W2151051731 creator A5001156301 @default.
• W2151051731 creator A5022002853 @default.
• W2151051731 creator A5032531138 @default.
• W2151051731 creator A5062363011 @default.
• W2151051731 creator A5088608614 @default.
• W2151051731 date "2010-10-21" @default.
• W2151051731 modified "2023-09-23" @default.
• W2151051731 title "Acetylcholine acutely modifies nitric oxide synthase function in the human coronary circulation" @default.
• W2151051731 cites W1493624699 @default.
• W2151051731 cites W1970161435 @default.
• W2151051731 cites W1973407863 @default.
• W2151051731 cites W1974528590 @default.
• W2151051731 cites W1982237924 @default.
• W2151051731 cites W1985678955 @default.
• W2151051731 cites W1990657704 @default.
• W2151051731 cites W1994271810 @default.
• W2151051731 cites W1996629436 @default.
• W2151051731 cites W1998418731 @default.
• W2151051731 cites W1999325861 @default.
• W2151051731 cites W2003233163 @default.
• W2151051731 cites W2008354631 @default.
• W2151051731 cites W2012223673 @default.
• W2151051731 cites W2015212759 @default.
• W2151051731 cites W2022699060 @default.
• W2151051731 cites W2026215531 @default.
• W2151051731 cites W2034051675 @default.
• W2151051731 cites W2034362431 @default.
• W2151051731 cites W2037291567 @default.
• W2151051731 cites W2039666558 @default.
• W2151051731 cites W2050548878 @default.
• W2151051731 cites W2052232788 @default.
• W2151051731 cites W2053813964 @default.
• W2151051731 cites W2054212891 @default.
• W2151051731 cites W2057116025 @default.
• W2151051731 cites W2059571803 @default.
• W2151051731 cites W2062650920 @default.
• W2151051731 cites W2065757982 @default.
• W2151051731 cites W2066850633 @default.
• W2151051731 cites W2069174503 @default.
• W2151051731 cites W2069490874 @default.
• W2151051731 cites W2070637832 @default.
• W2151051731 cites W2071740081 @default.
• W2151051731 cites W2074166999 @default.
• W2151051731 cites W2077941478 @default.
• W2151051731 cites W2082708534 @default.
• W2151051731 cites W2083565776 @default.
• W2151051731 cites W2086100475 @default.
• W2151051731 cites W2086447007 @default.
• W2151051731 cites W2087201131 @default.
• W2151051731 cites W2098515496 @default.
• W2151051731 cites W2107611836 @default.
• W2151051731 cites W2110267628 @default.
• W2151051731 cites W2116117957 @default.
• W2151051731 cites W2142653039 @default.
• W2151051731 cites W2149404536 @default.
• W2151051731 cites W2150616706 @default.
• W2151051731 cites W2155056314 @default.
• W2151051731 cites W2158387263 @default.
• W2151051731 cites W2165304543 @default.
• W2151051731 cites W2166150279 @default.
• W2151051731 cites W2190156091 @default.
• W2151051731 cites W2320405366 @default.
• W2151051731 cites W2405294128 @default.
• W2151051731 cites W2462053858 @default.
• W2151051731 cites W4254181710 @default.
• W2151051731 doi "https://doi.org/10.1113/expphysiol.2010.053926" @default.
• W2151051731 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20817701" @default.
• W2151051731 hasPublicationYear "2010" @default.
• W2151051731 type Work @default.
• W2151051731 sameAs 2151051731 @default.
• W2151051731 citedByCount "4" @default.
• W2151051731 countsByYear W21510517312017 @default.
• W2151051731 countsByYear W21510517312021 @default.
• W2151051731 countsByYear W21510517312022 @default.
• W2151051731 crossrefType "journal-article" @default.
• W2151051731 hasAuthorship W2151051731A5001156301 @default.
• W2151051731 hasAuthorship W2151051731A5022002853 @default.
• W2151051731 hasAuthorship W2151051731A5032531138 @default.
• W2151051731 hasAuthorship W2151051731A5062363011 @default.
• W2151051731 hasAuthorship W2151051731A5088608614 @default.
• W2151051731 hasBestOaLocation W21510517311 @default.
• W2151051731 hasConcept C126322002 @default.
• W2151051731 hasConcept C158846371 @default.
• W2151051731 hasConcept C164705383 @default.
• W2151051731 hasConcept C178790620 @default.
• W2151051731 hasConcept C185592680 @default.
• W2151051731 hasConcept C2776157398 @default.
• W2151051731 hasConcept C2778213512 @default.
• W2151051731 hasConcept C2778259205 @default.
• W2151051731 hasConcept C2991716557 @default.
• W2151051731 hasConcept C540031477 @default.
• W2151051731 hasConcept C71924100 @default.
• W2151051731 hasConcept C76538665 @default.
• W2151051731 hasConceptScore W2151051731C126322002 @default.
• W2151051731 hasConceptScore W2151051731C158846371 @default.
• W2151051731 hasConceptScore W2151051731C164705383 @default.

• next