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- W2151052291 abstract "OX40 is a member of the TNF receptor family expressed on activated and regulatory T (Treg) cells. Using an Ox40-cre allele for lineage marking, we found that a subpopulation of naive T cells had also previously expressed OX40 in the thymus. Ox40-cre was induced in a small fraction of thymocytes that were OX40(+), some of which were CD25(high) Treg cell precursors. Thymic OX40 expression distinguished cells experiencing a strong signaling response to positive selection. Naive T cells that had previously expressed OX40 demonstrated a partially activated phenotype that was distinct from that of most naive T cells. The results are consistent with the selection of Treg cells and a minor subpopulation of naive T cells being dependent on strong signaling responses to thymic self ligands." @default.
- W2151052291 created "2016-06-24" @default.
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- W2151052291 date "2009-04-15" @default.
- W2151052291 modified "2023-10-08" @default.
- W2151052291 title "Thymic OX40 Expression Discriminates Cells Undergoing Strong Responses to Selection Ligands" @default.
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- W2151052291 doi "https://doi.org/10.4049/jimmunol.0900010" @default.
- W2151052291 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2736618" @default.
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