Matches in SemOpenAlex for { <https://semopenalex.org/work/W2151092524> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2151092524 endingPage "950" @default.
- W2151092524 startingPage "942" @default.
- W2151092524 abstract "<h2>Abstract</h2> Information about intramural propagation of electrical excitation is crucial to understanding arrhythmia mechanisms in thick ventricular muscle. There is currently a controversy over whether it is possible to extract such information from the shape of the upstroke in optical mapping recordings. We show that even in the complex geometry of a whole guinea pig heart, optical upstroke morphology reveals the 3D wavefront orientation near the surface. To characterize the upstroke morphology, we use <mml:math><mml:mrow><mml:mi>V</mml:mi>F<mml:mo>∗</mml:mo></mml:mrow></mml:math>, the fractional level at which voltage-sensitive fluorescence, <i>V</i><sub>F</sub>, has maximal time derivative. Low values of <mml:math><mml:mrow><mml:mi>V</mml:mi>F<mml:mo>*</mml:mo> <mml:mo>(</mml:mo><mml:mo>∼</mml:mo><mml:mn>0.2</mml:mn><mml:mo>)</mml:mo></mml:mrow></mml:math> indicate a wavefront moving away from the surface, high values of <mml:math><mml:mrow><mml:mi>V</mml:mi>F<mml:mo>*</mml:mo> <mml:mo>(</mml:mo><mml:mo>∼</mml:mo><mml:mn>0.4</mml:mn><mml:mo>)</mml:mo></mml:mrow></mml:math> a wavefront moving toward the surface, and intermediate values of <mml:math><mml:mrow><mml:mi>V</mml:mi>F<mml:mo>*</mml:mo> <mml:mo>(</mml:mo><mml:mo>∼</mml:mo><mml:mn>0.6</mml:mn><mml:mo>)</mml:mo></mml:mrow></mml:math> a wavefront moving parallel to the surface. We further performed computer simulations using Luo-Rudy II electrophysiology and a simplified 3D geometry. The simulated <mml:math><mml:mrow><mml:mi>V</mml:mi><mml:mrow></mml:mrow><mml:mo>*</mml:mo></mml:mrow></mml:math> maps for free wall and apical stimulations as well as for sinus rhythm are in good quantitative agreement with the averaged experimental results. Furthermore, computer simulations show that the effect of the curvature of the heart on wave propagation is negligible." @default.
- W2151092524 created "2016-06-24" @default.
- W2151092524 creator A5015636460 @default.
- W2151092524 creator A5040682830 @default.
- W2151092524 creator A5045862650 @default.
- W2151092524 creator A5069326283 @default.
- W2151092524 creator A5091422805 @default.
- W2151092524 date "2008-07-01" @default.
- W2151092524 modified "2023-09-29" @default.
- W2151092524 title "Extracting Intramural Wavefront Orientation from Optical Upstroke Shapes in Whole Hearts" @default.
- W2151092524 cites W1972673540 @default.
- W2151092524 cites W1978536974 @default.
- W2151092524 cites W1997277858 @default.
- W2151092524 cites W2007048636 @default.
- W2151092524 cites W2022751629 @default.
- W2151092524 cites W2027178774 @default.
- W2151092524 cites W2038131479 @default.
- W2151092524 cites W2038827664 @default.
- W2151092524 cites W2046463907 @default.
- W2151092524 cites W2061917459 @default.
- W2151092524 cites W2065200530 @default.
- W2151092524 cites W2068676080 @default.
- W2151092524 cites W2069512245 @default.
- W2151092524 cites W2081888511 @default.
- W2151092524 cites W2089190535 @default.
- W2151092524 cites W2100616946 @default.
- W2151092524 cites W2106257230 @default.
- W2151092524 cites W2112532022 @default.
- W2151092524 cites W2116895717 @default.
- W2151092524 cites W2124370203 @default.
- W2151092524 cites W2128357006 @default.
- W2151092524 cites W2138206532 @default.
- W2151092524 cites W2147203062 @default.
- W2151092524 cites W2147606003 @default.
- W2151092524 cites W2170426408 @default.
- W2151092524 cites W2058716064 @default.
- W2151092524 doi "https://doi.org/10.1529/biophysj.107.117887" @default.
- W2151092524 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2440455" @default.
- W2151092524 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18390615" @default.
- W2151092524 hasPublicationYear "2008" @default.
- W2151092524 type Work @default.
- W2151092524 sameAs 2151092524 @default.
- W2151092524 citedByCount "24" @default.
- W2151092524 countsByYear W21510925242012 @default.
- W2151092524 countsByYear W21510925242013 @default.
- W2151092524 countsByYear W21510925242014 @default.
- W2151092524 countsByYear W21510925242015 @default.
- W2151092524 countsByYear W21510925242016 @default.
- W2151092524 countsByYear W21510925242018 @default.
- W2151092524 countsByYear W21510925242019 @default.
- W2151092524 countsByYear W21510925242021 @default.
- W2151092524 countsByYear W21510925242022 @default.
- W2151092524 countsByYear W21510925242023 @default.
- W2151092524 crossrefType "journal-article" @default.
- W2151092524 hasAuthorship W2151092524A5015636460 @default.
- W2151092524 hasAuthorship W2151092524A5040682830 @default.
- W2151092524 hasAuthorship W2151092524A5045862650 @default.
- W2151092524 hasAuthorship W2151092524A5069326283 @default.
- W2151092524 hasAuthorship W2151092524A5091422805 @default.
- W2151092524 hasBestOaLocation W21510925241 @default.
- W2151092524 hasConcept C11413529 @default.
- W2151092524 hasConcept C16345878 @default.
- W2151092524 hasConcept C192562407 @default.
- W2151092524 hasConcept C2524010 @default.
- W2151092524 hasConcept C33923547 @default.
- W2151092524 hasConcept C41008148 @default.
- W2151092524 hasConceptScore W2151092524C11413529 @default.
- W2151092524 hasConceptScore W2151092524C16345878 @default.
- W2151092524 hasConceptScore W2151092524C192562407 @default.
- W2151092524 hasConceptScore W2151092524C2524010 @default.
- W2151092524 hasConceptScore W2151092524C33923547 @default.
- W2151092524 hasConceptScore W2151092524C41008148 @default.
- W2151092524 hasIssue "2" @default.
- W2151092524 hasLocation W21510925241 @default.
- W2151092524 hasLocation W21510925242 @default.
- W2151092524 hasLocation W21510925243 @default.
- W2151092524 hasLocation W21510925244 @default.
- W2151092524 hasOpenAccess W2151092524 @default.
- W2151092524 hasPrimaryLocation W21510925241 @default.
- W2151092524 hasRelatedWork W1580015281 @default.
- W2151092524 hasRelatedWork W2054069972 @default.
- W2151092524 hasRelatedWork W2102233839 @default.
- W2151092524 hasRelatedWork W2148464976 @default.
- W2151092524 hasRelatedWork W2149562911 @default.
- W2151092524 hasRelatedWork W2362148275 @default.
- W2151092524 hasRelatedWork W2390761777 @default.
- W2151092524 hasRelatedWork W2899084033 @default.
- W2151092524 hasRelatedWork W3080304432 @default.
- W2151092524 hasRelatedWork W2497086861 @default.
- W2151092524 hasVolume "95" @default.
- W2151092524 isParatext "false" @default.
- W2151092524 isRetracted "false" @default.
- W2151092524 magId "2151092524" @default.
- W2151092524 workType "article" @default.