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- W2151093669 abstract "With the purpose of assessing the influence of beta 1 – adrenoblockes (β1 – AB) upon the state of cerebral hemodynamic for the patients with essential hypertension (EH), acute pharmacological test with tenolol (Atenosan, “Sanofi”) and nebivolol (Nebilete, “Berlin Chemie) was performed. Fifty patients with EH stage 2 complicated with the heart failure (HF) stage 2 were observed. In the 1st group (26 patients) atenolol (50 mg daily) was administered for five days, and in the 2nd group of the patients (24 patients) nebivolol (5 mg daily) was taken for the same period. The condition of the blood supplying of the brain was examined by the Computer Rheoencephalography (CREG) investigation, which was performed before the treatment, and on the fifth day of β1 – AB administration. There were not significant differences in central hemodynamic parameters between the 1st and 2nd group of the patients before the treatment (p>0.05). In the basin of a. carotis interna the blood filling was normal (p>0.05), the tonus of the main brain vessels and arterioles was increased (p>0.05), and the venous outflow was inconvenienced. The blood filling of the main arteries had grown worse for 22% (p>0.05), and the tonus was increased for 17% (p>0.05) after atenolol administration. There was fixed a tendency for improvement of these parameters for 7% and 10% (p>0.05) respectively after nebivolol administration. Both atenolol and nebivolol administration made the venous outflow uncertainly worse (p>0.05) on the fifth day of the acute pharmacological test. Thus, it is more purposeful and safe to use nebivolol for the treatment of patients with essential hypertension and heart failure complicated with hypertensive dystonia of vertebrobasilar vessels." @default.
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- W2151093669 date "2001-11-01" @default.
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- W2151093669 title "Atenolol and nevibolol: comparative influence on parameters of the cerebral hemodynamic in the patients with essential hypertension" @default.
- W2151093669 doi "https://doi.org/10.1016/s0895-7061(01)02109-4" @default.
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