Matches in SemOpenAlex for { <https://semopenalex.org/work/W2151102166> ?p ?o ?g. }
- W2151102166 endingPage "991" @default.
- W2151102166 startingPage "979" @default.
- W2151102166 abstract "The self-renewal capacity ascribed to embryonic stem cells (ESC) is reminiscent of cancer cell proliferation, raising speculation that a common network of genes may regulate these traits. A search for general regulators of these traits yielded a set of microRNAs for which expression is highly enriched in human ESCs and liver cancer cells (HCC) but attenuated in differentiated quiescent hepatocytes. Here, we show that these microRNAs promote hESC self-renewal, as well as HCC proliferation, and when overexpressed in normally quiescent hepatocytes, induce proliferation and activate cancer signaling pathways. Proliferation in hepatocytes is mediated through translational repression of Pten, Tgfbr2, Klf11, and Cdkn1a, which collectively dysregulates the PI3K/AKT/mTOR and TGFβ tumor suppressor signaling pathways. Furthermore, aberrant expression of these miRNAs is observed in human liver tumor tissues and induces epithelial–mesenchymal transition in hepatocytes. These findings suggest that microRNAs that are essential in normal development as promoters of ESC self-renewal are frequently upregulated in human liver tumors and harbor neoplastic transformation potential when they escape silencing in quiescent human hepatocytes. Mol Cancer Res; 10(7); 979–91. ©2012 AACR." @default.
- W2151102166 created "2016-06-24" @default.
- W2151102166 creator A5007716183 @default.
- W2151102166 creator A5011434362 @default.
- W2151102166 creator A5018173206 @default.
- W2151102166 creator A5034247766 @default.
- W2151102166 creator A5050153062 @default.
- W2151102166 creator A5053605944 @default.
- W2151102166 creator A5056308215 @default.
- W2151102166 creator A5064276499 @default.
- W2151102166 creator A5065331949 @default.
- W2151102166 date "2012-05-23" @default.
- W2151102166 modified "2023-09-25" @default.
- W2151102166 title "Human ESC Self-renewal Promoting microRNAs Induce Epithelial–Mesenchymal Transition in Hepatocytes by Controlling the PTEN and TGFβ Tumor Suppressor Signaling Pathways" @default.
- W2151102166 cites W1920303762 @default.
- W2151102166 cites W1965281877 @default.
- W2151102166 cites W1965676298 @default.
- W2151102166 cites W1973890143 @default.
- W2151102166 cites W1982786429 @default.
- W2151102166 cites W2004280138 @default.
- W2151102166 cites W2009629707 @default.
- W2151102166 cites W2009671859 @default.
- W2151102166 cites W2017112248 @default.
- W2151102166 cites W2032580087 @default.
- W2151102166 cites W2033364737 @default.
- W2151102166 cites W2034682317 @default.
- W2151102166 cites W2034745491 @default.
- W2151102166 cites W2037578309 @default.
- W2151102166 cites W2038625523 @default.
- W2151102166 cites W2045402423 @default.
- W2151102166 cites W2053355345 @default.
- W2151102166 cites W2054521968 @default.
- W2151102166 cites W2065825082 @default.
- W2151102166 cites W2073759231 @default.
- W2151102166 cites W2075123253 @default.
- W2151102166 cites W2077582389 @default.
- W2151102166 cites W2078576279 @default.
- W2151102166 cites W2083381199 @default.
- W2151102166 cites W2084284022 @default.
- W2151102166 cites W2085592081 @default.
- W2151102166 cites W2086943348 @default.
- W2151102166 cites W2092513068 @default.
- W2151102166 cites W2094068658 @default.
- W2151102166 cites W2098267886 @default.
- W2151102166 cites W2099517697 @default.
- W2151102166 cites W2102085111 @default.
- W2151102166 cites W2103689264 @default.
- W2151102166 cites W2111783800 @default.
- W2151102166 cites W2113530405 @default.
- W2151102166 cites W2121058644 @default.
- W2151102166 cites W2124471593 @default.
- W2151102166 cites W2125987139 @default.
- W2151102166 cites W2128561360 @default.
- W2151102166 cites W2135447662 @default.
- W2151102166 cites W2135810600 @default.
- W2151102166 cites W2146415848 @default.
- W2151102166 cites W2154589460 @default.
- W2151102166 cites W2159888101 @default.
- W2151102166 cites W2159956387 @default.
- W2151102166 cites W2171488801 @default.
- W2151102166 doi "https://doi.org/10.1158/1541-7786.mcr-11-0421" @default.
- W2151102166 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4166560" @default.
- W2151102166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22622027" @default.
- W2151102166 hasPublicationYear "2012" @default.
- W2151102166 type Work @default.
- W2151102166 sameAs 2151102166 @default.
- W2151102166 citedByCount "21" @default.
- W2151102166 countsByYear W21511021662013 @default.
- W2151102166 countsByYear W21511021662014 @default.
- W2151102166 countsByYear W21511021662015 @default.
- W2151102166 countsByYear W21511021662016 @default.
- W2151102166 countsByYear W21511021662017 @default.
- W2151102166 countsByYear W21511021662018 @default.
- W2151102166 countsByYear W21511021662020 @default.
- W2151102166 crossrefType "journal-article" @default.
- W2151102166 hasAuthorship W2151102166A5007716183 @default.
- W2151102166 hasAuthorship W2151102166A5011434362 @default.
- W2151102166 hasAuthorship W2151102166A5018173206 @default.
- W2151102166 hasAuthorship W2151102166A5034247766 @default.
- W2151102166 hasAuthorship W2151102166A5050153062 @default.
- W2151102166 hasAuthorship W2151102166A5053605944 @default.
- W2151102166 hasAuthorship W2151102166A5056308215 @default.
- W2151102166 hasAuthorship W2151102166A5064276499 @default.
- W2151102166 hasAuthorship W2151102166A5065331949 @default.
- W2151102166 hasBestOaLocation W21511021661 @default.
- W2151102166 hasConcept C104317684 @default.
- W2151102166 hasConcept C119056186 @default.
- W2151102166 hasConcept C121608353 @default.
- W2151102166 hasConcept C127561419 @default.
- W2151102166 hasConcept C145059251 @default.
- W2151102166 hasConcept C145103041 @default.
- W2151102166 hasConcept C179185449 @default.
- W2151102166 hasConcept C2777609662 @default.
- W2151102166 hasConcept C502942594 @default.
- W2151102166 hasConcept C54355233 @default.
- W2151102166 hasConcept C62112901 @default.
- W2151102166 hasConcept C62478195 @default.
- W2151102166 hasConcept C75217442 @default.