Matches in SemOpenAlex for { <https://semopenalex.org/work/W2151121784> ?p ?o ?g. }
- W2151121784 endingPage "4054" @default.
- W2151121784 startingPage "4039" @default.
- W2151121784 abstract "This study presents a mechanistic QSAR analysis of human intestinal absorption of drugs and drug-like compounds using a data set of 567 %HIA values. Experimental data represent passive diffusion across intestinal membranes, and are considered to be reasonably free of carrier-mediated transport or other unwanted effects. A nonlinear model was developed relating %HIA to physicochemical properties of drugs (lipophilicity, ionization, hydrogen bonding, and molecular size). The model describes ion-specific intestinal permeability of drugs by both transcellular and paracellular routes, and also accounts for unstirred water layer effects. The obtained model was validated on two external data sets consisting of in vivo human jejunal permeability coefficients (Peff) and absorption rate constants (Ka). Validation results demonstrate good predictive power of the model (RMSE=0.35–0.45 log units for logKa and logPeff). High prediction accuracy together with clear physicochemical interpretation (logP, pKa) makes this model particularly suitable for use in property-based drug design. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 98:4039–4054, 2009" @default.
- W2151121784 created "2016-06-24" @default.
- W2151121784 creator A5012501898 @default.
- W2151121784 creator A5039031718 @default.
- W2151121784 creator A5041209377 @default.
- W2151121784 creator A5045665024 @default.
- W2151121784 creator A5090656712 @default.
- W2151121784 date "2009-11-01" @default.
- W2151121784 modified "2023-10-17" @default.
- W2151121784 title "Ionization-specific analysis of human intestinal absorption" @default.
- W2151121784 cites W1489601464 @default.
- W2151121784 cites W1510224559 @default.
- W2151121784 cites W1527851449 @default.
- W2151121784 cites W1588629348 @default.
- W2151121784 cites W180401638 @default.
- W2151121784 cites W1963813830 @default.
- W2151121784 cites W1964379108 @default.
- W2151121784 cites W1968478164 @default.
- W2151121784 cites W1970250279 @default.
- W2151121784 cites W1971467209 @default.
- W2151121784 cites W1984271704 @default.
- W2151121784 cites W1991327891 @default.
- W2151121784 cites W1991443437 @default.
- W2151121784 cites W1991512646 @default.
- W2151121784 cites W1991994385 @default.
- W2151121784 cites W1997716632 @default.
- W2151121784 cites W1998584026 @default.
- W2151121784 cites W2000256393 @default.
- W2151121784 cites W2003873735 @default.
- W2151121784 cites W2007052092 @default.
- W2151121784 cites W2011678531 @default.
- W2151121784 cites W2015543341 @default.
- W2151121784 cites W2017946427 @default.
- W2151121784 cites W2020485499 @default.
- W2151121784 cites W2020631613 @default.
- W2151121784 cites W2022986959 @default.
- W2151121784 cites W2024012503 @default.
- W2151121784 cites W2024428899 @default.
- W2151121784 cites W2029590089 @default.
- W2151121784 cites W2030823283 @default.
- W2151121784 cites W2031742675 @default.
- W2151121784 cites W2032747912 @default.
- W2151121784 cites W2032865438 @default.
- W2151121784 cites W2038344991 @default.
- W2151121784 cites W2039522817 @default.
- W2151121784 cites W2040930785 @default.
- W2151121784 cites W2041725964 @default.
- W2151121784 cites W2050306737 @default.
- W2151121784 cites W2050328092 @default.
- W2151121784 cites W2059032639 @default.
- W2151121784 cites W2060318369 @default.
- W2151121784 cites W2061131594 @default.
- W2151121784 cites W2063577652 @default.
- W2151121784 cites W2065602354 @default.
- W2151121784 cites W2073101936 @default.
- W2151121784 cites W2080953214 @default.
- W2151121784 cites W2084375116 @default.
- W2151121784 cites W2086106390 @default.
- W2151121784 cites W2089494909 @default.
- W2151121784 cites W2099014892 @default.
- W2151121784 cites W2136564762 @default.
- W2151121784 cites W2145017630 @default.
- W2151121784 cites W2153110742 @default.
- W2151121784 cites W2157970175 @default.
- W2151121784 cites W2220807183 @default.
- W2151121784 cites W4248107770 @default.
- W2151121784 cites W71151985 @default.
- W2151121784 doi "https://doi.org/10.1002/jps.21730" @default.
- W2151121784 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19360843" @default.
- W2151121784 hasPublicationYear "2009" @default.
- W2151121784 type Work @default.
- W2151121784 sameAs 2151121784 @default.
- W2151121784 citedByCount "34" @default.
- W2151121784 countsByYear W21511217842012 @default.
- W2151121784 countsByYear W21511217842013 @default.
- W2151121784 countsByYear W21511217842014 @default.
- W2151121784 countsByYear W21511217842015 @default.
- W2151121784 countsByYear W21511217842016 @default.
- W2151121784 countsByYear W21511217842017 @default.
- W2151121784 countsByYear W21511217842019 @default.
- W2151121784 countsByYear W21511217842020 @default.
- W2151121784 countsByYear W21511217842021 @default.
- W2151121784 crossrefType "journal-article" @default.
- W2151121784 hasAuthorship W2151121784A5012501898 @default.
- W2151121784 hasAuthorship W2151121784A5039031718 @default.
- W2151121784 hasAuthorship W2151121784A5041209377 @default.
- W2151121784 hasAuthorship W2151121784A5045665024 @default.
- W2151121784 hasAuthorship W2151121784A5090656712 @default.
- W2151121784 hasConcept C113196181 @default.
- W2151121784 hasConcept C120882062 @default.
- W2151121784 hasConcept C125287762 @default.
- W2151121784 hasConcept C150903083 @default.
- W2151121784 hasConcept C159985019 @default.
- W2151121784 hasConcept C164126121 @default.
- W2151121784 hasConcept C176285220 @default.
- W2151121784 hasConcept C185592680 @default.
- W2151121784 hasConcept C186060115 @default.
- W2151121784 hasConcept C192562407 @default.