FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2151162020> ?p ?o ?g. }

• W2151162020 endingPage "1976" @default.
• W2151162020 startingPage "1968" @default.
• W2151162020 abstract "Impaired angiogenesis induced by vascular endothelial growth factor (VEGF) resistance is a hallmark of vascular complications in type 2 diabetes; however, its molecular mechanism is not fully understood. We have previously identified selenoprotein P (SeP, encoded by the SEPP1 gene in humans) as a liver-derived secretory protein that induces insulin resistance. Levels of serum SeP and hepatic expression of SEPP1 are elevated in type 2 diabetes. Here, we investigated the effects of SeP on VEGF signalling and angiogenesis.We assessed the action of glucose on Sepp1 expression in cultured hepatocytes. We examined the actions of SeP on VEGF signalling and VEGF-induced angiogenesis in HUVECs. We assessed wound healing in mice with hepatic SeP overexpression or SeP deletion. The blood flow recovery after ischaemia was also examined by using hindlimb ischaemia model with Sepp1-heterozygous-knockout mice.Treatment with glucose increased gene expression and transcriptional activity for Sepp1 in H4IIEC hepatocytes. Physiological concentrations of SeP inhibited VEGF-stimulated cell proliferation, tubule formation and migration in HUVECs. SeP suppressed VEGF-induced reactive oxygen species (ROS) generation and phosphorylation of VEGF receptor 2 (VEGFR2) and extracellular signal-regulated kinase 1/2 (ERK1/2) in HUVECs. Wound closure was impaired in the mice overexpressing Sepp1, whereas it was improved in SeP (-/-)mice. SeP (+/-)mice showed an increase in blood flow recovery and vascular endothelial cells after hindlimb ischaemia.The hepatokine SeP may be a novel therapeutic target for impaired angiogenesis in type 2 diabetes." @default.
• W2151162020 created "2016-06-24" @default.
• W2151162020 creator A5012910352 @default.
• W2151162020 creator A5016801438 @default.
• W2151162020 creator A5036011690 @default.
• W2151162020 creator A5036757365 @default.
• W2151162020 creator A5039655833 @default.
• W2151162020 creator A5044476969 @default.
• W2151162020 creator A5046114557 @default.
• W2151162020 creator A5046506553 @default.
• W2151162020 creator A5048428441 @default.
• W2151162020 creator A5058121331 @default.
• W2151162020 creator A5062876989 @default.
• W2151162020 creator A5068623243 @default.
• W2151162020 creator A5069065380 @default.
• W2151162020 creator A5070669879 @default.
• W2151162020 creator A5072175595 @default.
• W2151162020 creator A5074222420 @default.
• W2151162020 creator A5077456007 @default.
• W2151162020 creator A5081059491 @default.
• W2151162020 creator A5081432607 @default.
• W2151162020 creator A5083886600 @default.
• W2151162020 creator A5085708092 @default.
• W2151162020 creator A5088365918 @default.
• W2151162020 creator A5089497139 @default.
• W2151162020 creator A5090254767 @default.
• W2151162020 date "2014-07-03" @default.
• W2151162020 modified "2023-10-13" @default.
• W2151162020 title "Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells" @default.
• W2151162020 cites W154322005 @default.
• W2151162020 cites W172609984 @default.
• W2151162020 cites W1972125572 @default.
• W2151162020 cites W1975835080 @default.
• W2151162020 cites W1978261657 @default.
• W2151162020 cites W1978282413 @default.
• W2151162020 cites W1986351037 @default.
• W2151162020 cites W1989086481 @default.
• W2151162020 cites W1989483643 @default.
• W2151162020 cites W1992366656 @default.
• W2151162020 cites W1996441807 @default.
• W2151162020 cites W2011198909 @default.
• W2151162020 cites W2019182002 @default.
• W2151162020 cites W2025882468 @default.
• W2151162020 cites W2033654570 @default.
• W2151162020 cites W2036496650 @default.
• W2151162020 cites W2040168311 @default.
• W2151162020 cites W2047440477 @default.
• W2151162020 cites W2050517931 @default.
• W2151162020 cites W2051268134 @default.
• W2151162020 cites W2060306388 @default.
• W2151162020 cites W2072486096 @default.
• W2151162020 cites W2074936957 @default.
• W2151162020 cites W2081430742 @default.
• W2151162020 cites W2085493921 @default.
• W2151162020 cites W2095336539 @default.
• W2151162020 cites W2096166220 @default.
• W2151162020 cites W2102500963 @default.
• W2151162020 cites W2102771571 @default.
• W2151162020 cites W2112715147 @default.
• W2151162020 cites W2120953129 @default.
• W2151162020 cites W2123907958 @default.
• W2151162020 cites W2125930202 @default.
• W2151162020 cites W2135849415 @default.
• W2151162020 cites W2158497159 @default.
• W2151162020 cites W2158551180 @default.
• W2151162020 cites W2161020839 @default.
• W2151162020 cites W2163839210 @default.
• W2151162020 cites W2171294019 @default.
• W2151162020 cites W2171548660 @default.
• W2151162020 cites W2219222827 @default.
• W2151162020 cites W2324138891 @default.
• W2151162020 doi "https://doi.org/10.1007/s00125-014-3306-9" @default.
• W2151162020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24989996" @default.
• W2151162020 hasPublicationYear "2014" @default.
• W2151162020 type Work @default.
• W2151162020 sameAs 2151162020 @default.
• W2151162020 citedByCount "56" @default.
• W2151162020 countsByYear W21511620202014 @default.
• W2151162020 countsByYear W21511620202015 @default.
• W2151162020 countsByYear W21511620202016 @default.
• W2151162020 countsByYear W21511620202017 @default.
• W2151162020 countsByYear W21511620202018 @default.
• W2151162020 countsByYear W21511620202019 @default.
• W2151162020 countsByYear W21511620202020 @default.
• W2151162020 countsByYear W21511620202021 @default.
• W2151162020 countsByYear W21511620202022 @default.
• W2151162020 countsByYear W21511620202023 @default.
• W2151162020 crossrefType "journal-article" @default.
• W2151162020 hasAuthorship W2151162020A5012910352 @default.
• W2151162020 hasAuthorship W2151162020A5016801438 @default.
• W2151162020 hasAuthorship W2151162020A5036011690 @default.
• W2151162020 hasAuthorship W2151162020A5036757365 @default.
• W2151162020 hasAuthorship W2151162020A5039655833 @default.
• W2151162020 hasAuthorship W2151162020A5044476969 @default.
• W2151162020 hasAuthorship W2151162020A5046114557 @default.
• W2151162020 hasAuthorship W2151162020A5046506553 @default.
• W2151162020 hasAuthorship W2151162020A5048428441 @default.
• W2151162020 hasAuthorship W2151162020A5058121331 @default.

• next