Matches in SemOpenAlex for { <https://semopenalex.org/work/W2151164793> ?p ?o ?g. }
- W2151164793 endingPage "1789" @default.
- W2151164793 startingPage "1786" @default.
- W2151164793 abstract "NKT cells represent a distinct lineage of T cells that coexpress a conserved alphabeta T cell receptor (TCR) and natural killer (NK) receptors. Although the TCR of NKT cells is characteristically autoreactive to CD1d, a lipid-presenting molecule, endogenous ligands for these cells have not been identified. We show that a lysosomal glycosphingolipid of previously unknown function, isoglobotrihexosylceramide (iGb3), is recognized both by mouse and human NKT cells. Impaired generation of lysosomal iGb3 in mice lacking beta-hexosaminidase b results in severe NKT cell deficiency, suggesting that this lipid also mediates development of NKT cells in the mouse. We suggest that expression of iGb3 in peripheral tissues may be involved in controlling NKT cell responses to infections and malignancy and in autoimmunity." @default.
- W2151164793 created "2016-06-24" @default.
- W2151164793 creator A5005032064 @default.
- W2151164793 creator A5007598672 @default.
- W2151164793 creator A5008555720 @default.
- W2151164793 creator A5008666868 @default.
- W2151164793 creator A5010330990 @default.
- W2151164793 creator A5013976745 @default.
- W2151164793 creator A5016549628 @default.
- W2151164793 creator A5023002972 @default.
- W2151164793 creator A5040716998 @default.
- W2151164793 creator A5046086498 @default.
- W2151164793 creator A5048492327 @default.
- W2151164793 creator A5049356618 @default.
- W2151164793 creator A5065836871 @default.
- W2151164793 creator A5075864355 @default.
- W2151164793 creator A5076516879 @default.
- W2151164793 creator A5080749555 @default.
- W2151164793 creator A5089605387 @default.
- W2151164793 date "2004-12-03" @default.
- W2151164793 modified "2023-10-14" @default.
- W2151164793 title "Lysosomal Glycosphingolipid Recognition by NKT Cells" @default.
- W2151164793 cites W1553276030 @default.
- W2151164793 cites W1959677146 @default.
- W2151164793 cites W1973050697 @default.
- W2151164793 cites W1976710853 @default.
- W2151164793 cites W1978564700 @default.
- W2151164793 cites W1987950952 @default.
- W2151164793 cites W1994581518 @default.
- W2151164793 cites W1994844958 @default.
- W2151164793 cites W2008585980 @default.
- W2151164793 cites W2023641192 @default.
- W2151164793 cites W2026802569 @default.
- W2151164793 cites W2027841252 @default.
- W2151164793 cites W2032416398 @default.
- W2151164793 cites W2035337456 @default.
- W2151164793 cites W2040112038 @default.
- W2151164793 cites W2046549183 @default.
- W2151164793 cites W2058201892 @default.
- W2151164793 cites W2062058925 @default.
- W2151164793 cites W2064495692 @default.
- W2151164793 cites W2071530096 @default.
- W2151164793 cites W2076024275 @default.
- W2151164793 cites W2089940031 @default.
- W2151164793 cites W2111947207 @default.
- W2151164793 cites W2121895986 @default.
- W2151164793 cites W2135505001 @default.
- W2151164793 cites W2148115090 @default.
- W2151164793 cites W2161307276 @default.
- W2151164793 cites W2165349863 @default.
- W2151164793 cites W2172105693 @default.
- W2151164793 doi "https://doi.org/10.1126/science.1103440" @default.
- W2151164793 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15539565" @default.
- W2151164793 hasPublicationYear "2004" @default.
- W2151164793 type Work @default.
- W2151164793 sameAs 2151164793 @default.
- W2151164793 citedByCount "897" @default.
- W2151164793 countsByYear W21511647932012 @default.
- W2151164793 countsByYear W21511647932013 @default.
- W2151164793 countsByYear W21511647932014 @default.
- W2151164793 countsByYear W21511647932015 @default.
- W2151164793 countsByYear W21511647932016 @default.
- W2151164793 countsByYear W21511647932017 @default.
- W2151164793 countsByYear W21511647932018 @default.
- W2151164793 countsByYear W21511647932019 @default.
- W2151164793 countsByYear W21511647932020 @default.
- W2151164793 countsByYear W21511647932021 @default.
- W2151164793 countsByYear W21511647932022 @default.
- W2151164793 countsByYear W21511647932023 @default.
- W2151164793 crossrefType "journal-article" @default.
- W2151164793 hasAuthorship W2151164793A5005032064 @default.
- W2151164793 hasAuthorship W2151164793A5007598672 @default.
- W2151164793 hasAuthorship W2151164793A5008555720 @default.
- W2151164793 hasAuthorship W2151164793A5008666868 @default.
- W2151164793 hasAuthorship W2151164793A5010330990 @default.
- W2151164793 hasAuthorship W2151164793A5013976745 @default.
- W2151164793 hasAuthorship W2151164793A5016549628 @default.
- W2151164793 hasAuthorship W2151164793A5023002972 @default.
- W2151164793 hasAuthorship W2151164793A5040716998 @default.
- W2151164793 hasAuthorship W2151164793A5046086498 @default.
- W2151164793 hasAuthorship W2151164793A5048492327 @default.
- W2151164793 hasAuthorship W2151164793A5049356618 @default.
- W2151164793 hasAuthorship W2151164793A5065836871 @default.
- W2151164793 hasAuthorship W2151164793A5075864355 @default.
- W2151164793 hasAuthorship W2151164793A5076516879 @default.
- W2151164793 hasAuthorship W2151164793A5080749555 @default.
- W2151164793 hasAuthorship W2151164793A5089605387 @default.
- W2151164793 hasConcept C139563560 @default.
- W2151164793 hasConcept C19317047 @default.
- W2151164793 hasConcept C203014093 @default.
- W2151164793 hasConcept C2776090121 @default.
- W2151164793 hasConcept C2776931407 @default.
- W2151164793 hasConcept C2778607024 @default.
- W2151164793 hasConcept C37386791 @default.
- W2151164793 hasConcept C55493867 @default.
- W2151164793 hasConcept C86803240 @default.
- W2151164793 hasConcept C8891405 @default.
- W2151164793 hasConcept C95444343 @default.