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- W2151225828 abstract "The role of uterine blood flow (UBF) in the modulation of experimentally induced decidua formation was assessed in mature guinea pigs. The response to endometrial trauma, as indexed by uterine weight changes, was dependent upon the type of stimulus used, with deciduogenic effectiveness as follows: saline = oil = knife scratch less than scissor cut. Both the knife scratch and scissor cut techniques induced elevations in UBF compared with control values. Neither uterine weight nor UBF increased when trauma was applied to unresponsive uteri, indicating that inflammation was not the cause of uterine hyperemia. Uterine weight increased from basal levels on the day of trauma (i.e. day 5 of the estrous cycle) to a maximal weight between days 10 and 12 posttrauma. Maximal growth of the induced decidua occurred under conditions of elevated UBF. Subsequently, UBF declined between days 10 and 15 posttrauma, preceding the associate resorption of the induced decidua. During the period of decidua growth, serum progesterone levels were elevated compared with those in control animals. These data indicate that experimentally induced decidua formation in the guinea pig is associated with uterine hyperemia and increased corpus luteum activity, both of which are necessary for proper endometrial differentiation. It is hypothesized that these events mimic the uterine hyperemia associated with blastocyst implanplantation and early placentation in this species." @default.
- W2151225828 created "2016-06-24" @default.
- W2151225828 creator A5043522051 @default.
- W2151225828 date "1984-05-01" @default.
- W2151225828 modified "2023-09-23" @default.
- W2151225828 title "Decidual Tissue Growth and Regression in the Guinea Pig: Regulation by Uterine Blood Flow and Relation to Circulating Progesterone Concentrations*" @default.
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- W2151225828 doi "https://doi.org/10.1210/endo-114-5-1599" @default.
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