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• W2151240556 startingPage "337" @default.
• W2151240556 abstract "Transcription initiation involves the conversion from closed promoter complexes, comprising RNA polymerase (RNAP) and double-stranded promoter DNA, to open complexes, in which the enzyme is able to access the DNA template in a single-stranded form. The complex between bacterial RNAP and its major variant sigma factor sigma(54) remains as a closed complex until ATP hydrolysis-dependent remodeling by activator proteins occurs. This remodeling facilitates DNA melting and allows the transition to the open complex. Here we present cryoelectron microscopy reconstructions of bacterial RNAP in complex with sigma(54) alone, and of RNAP-sigma(54) with an AAA+ activator. Together with photo-crosslinking data that establish the location of promoter DNA within the complexes, we explain why the RNAP-sigma(54) closed complex is unable to access the DNA template and propose how the structural changes induced by activator binding can initiate conformational changes that ultimately result in formation of the open complex." @default.
• W2151240556 created "2016-06-24" @default.
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• W2151240556 date "2008-11-01" @default.
• W2151240556 modified "2023-10-16" @default.
• W2151240556 title "Organization of an Activator-Bound RNA Polymerase Holoenzyme" @default.
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• W2151240556 doi "https://doi.org/10.1016/j.molcel.2008.09.015" @default.
• W2151240556 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2680985" @default.
• W2151240556 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18995832" @default.
• W2151240556 hasPublicationYear "2008" @default.
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