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• W2151256777 abstract "Genetic redundancy is associated with a large percentage of genes. We investigated PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor gene functions that eluded single mutant analyses, using a Caenorhabditis elegans genome-wide screen. We show that at least 27 genes collaborate with the worm PTEN homolog daf-18 for various functions previously concealed by genetic redundancy, including embryogenesis, cuticle turnover, egg laying, and oocyte maturation. In one example, daf-18 appears to constitute a cell-autonomous germline signal that converges with a somatic gonad signal mediated by ceh-18 at a kinase inhibition. We provide evidence that daf-18 elicits some functions independent of the downstream gene daf-16." @default.
• W2151256777 created "2016-06-24" @default.
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• W2151256777 date "2006-02-15" @default.
• W2151256777 modified "2023-09-23" @default.
• W2151256777 title "Genetic redundancy masks diverse functions of the tumor suppressor gene <i>PTEN</i> during <i>C. elegans</i> development" @default.
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• W2151256777 doi "https://doi.org/10.1101/gad.1378906" @default.
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